Clinical trials: Post-operative Cardiac Surgery
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Post-operative Atrial Fibrillation, CABG
Empagliflozin to Prevent Post-Operative Atrial Fibrillation
This is an interventional, double-blind, placebo controlled, multicenter, randomized clinical trial with allocation sequence concealment and blinded endpoint adjudication.
- Trial name
- EMPOAF (NCT06124937)
- Testing
- Empagliflozin 10 MG
- Where
- 2 sites in Iran
- Volunteers
- 492 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Acute Kidney Injury, Cardiac Surgery
proMoting Effective Renoprotection in Cardiac sURgery Patients by Inhibition of SGLT-2
Multi-centre, triple-blinded (patients, physicians, investigators), parallel-group, balanced (1:1), stratified (sex, type 2 diabetes mellitus), randomized, controlled (placebo), phase IV clinical trial to investigate the…
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Sodium-Glucose Transporter 2 Inhibitor
- Trial name
- MERCURI-2 (NCT05590143)
- Testing
- Dapagliflozin 10 MG Oral Tablet [Farxiga]
- Where
- 6 sites in Netherlands
- Volunteers
- 784 people
- Sponsor
- Amsterdam UMC
Cohort Studies
Effect of Dexmedetomidine on Postoperative Mental Disorders and Long-term Survival in Elderly Patients
China's aging population is causing an increase in the number of senior persons undergoing surgery. More and more clinicians are paying attention to the postoperative survival and mental health of elderly surgical patients.
- Trial name
- NCT06362408
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery
Near Infrared Spectroscopy for the Detection of Acute Kidney Injury in Children Following Cardiac Surgery
One in a hundred children is born with a heart defect. Some children require heart surgery within the first few days of life, while others can wait until they are older.
- Conditions
- Acute Kidney Injury, Heart; Dysfunction Postoperative, Cardiac Surgery, Children
- Trial name
- NCT01382758
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Myocardial Injury After Non-Cardiac Surgery, Ischemia Reperfusion Injury
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms.
- Trial name
- NCT06895798
- Where
- 2 sites in China
- Volunteers
- 1,286 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs
Non-steroidal Anti-inflammatory in Cardiac Surgery
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding…
- Conditions
- Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery, Pain Intensity
- Trial name
- KETOPAIN (NCT06381063)
- Testing
- pain management, ketoprofen
- Where
- France
- Volunteers
- 238 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Heart Surgery
Effect of Oral Zinc and Vitamin E Supplementation on Short-term Postoperative Outcomes in Cardiac Surgery Patients.
Cardiac surgery can cause oxidative stress due to ischemia-reperfusion. Using antioxidants during perioperative period may help improve this condition. Vitamin E and zinc have antioxidant effects.
- Trial name
- NCT05402826
- Testing
- Oral zinc + vitamin E
- Where
- Iran
- Volunteers
- 78 people
- Sponsor
- Shahid Beheshti University
Delirium
Quetiapine as Prophylaxis for Delirium in CABG
low-dose quetiapine may be effective in preventing delirium in patients. The purpose of this study is to evaluate the efficacy and safety of quetiapine for delirium prophylaxis in cabg
- Trial name
- NCT05801289
- Testing
- Quetiapine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Nerve Block, Coronary Artery Bypass
Comparison of Erector Spinae Plane Block and Transversus Thoracic Muscle Plane Block in Coronary Artery Surgery
The main objective of this study is to evaluate postoperative pain intensity comparatively between erector spinae plane block and transversus thoracic muscle plane block in patients undergoing open coronary artery surgery.
- Conditions
- Nerve Block, Coronary Artery Bypass, Anesthesia and Analgesia
- Trial name
- NCT06709625
- Testing
- Transversus thoracis plane block, Erector spina plane block (ESP)
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ankara City Hospital Bilkent
Delirium, Bypass Complication
Care Bundle's Impact on Delirium Prevention in CABG Patients
This research investigates the effectiveness of a care package used in the care of patients undergoing coronary artery bypass graft (CABG) surgery in preventing postoperative delirium.
- Conditions
- Delirium, Bypass Complication, Coronary Artery Bypass, Patient Care Bundles
- Trial name
- CareBundle (NCT06036017)
- Testing
- Earplugs, Music Therapy, Presence of Family After Extubation:
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- İslam Elagöz
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
Fascicular Block, Motor Activity
The Effects of Different Clonidine Concentrations on Axillary Brachial Plexus Block With 1,5% Lidocaine
The purpose of this study is to determine whether different clonidine concentration on axillary brachial plexus block with 1,5% lidocaine for upper limb surgery may influence the sensory and motor block onset time and duration…
- Conditions
- Fascicular Block, Motor Activity, Pain, Postoperative, Latency Period
- Trial name
- NCT01620112
- Testing
- high Clonidine concentration, low clonidine concentration, Lidocaine
- Volunteers
- 60 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Postoperative;Pain Management
Effects of Serratus Posterior Superior Intercostal Plane Block and Pectoralis Nerve Block in Coronary Artery Surgery
Postoperative analgesia is a critical risk factor for the development of pulmonary and cardiovascular complications in all types of chest surgery, particularly coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT06242431
- Testing
- Group serratus posterior superior intercostal plane block (SPSIPB), Group pectoralis nerve block (PECS-II)
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Hitit University
Complications, Bleeding
Fibrinogen and Bleeding After Cardiac Surgery
The study hypothesis is that prophylactic fibrinogen infusion reduces postoperative bleeding and transfusion requirements after coronary artery bypass surgery (CABG) in patients with endogenous fibrinogen levels in the lower…
- Conditions
- Complications, Bleeding, Coronary Artery Disease
- Trial name
- Fibro-3 (NCT00968045)
- Testing
- Fibrinogen
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Sahlgrenska University Hospital
Sleep, Atrial Fibrillation
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so.
- Conditions
- Sleep, Atrial Fibrillation, Delirium, Postoperative, Complications, Postoperative
- Trial name
- NCT06527105
- Testing
- Eye masks and ear plugs
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Postoperative Neuronal Injury
Remote Ischemic Preconditioning and Postoperative Neuronal Injury
The SHIELD trial is a single-center, randomized, controlled, parallel-group, single-blinded clinical trial investigating whether performing RIPC one day before surgery-compared to not performing RIPC-reduces postoperative…
- Trial name
- SHIELD (NCT07420153)
- Testing
- Remote ischemic preconditioning, Routine care
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- University of Hamburg-Eppendorf
Postoperative Cognitive Decline, Postoperative Delirium
Daridorexant to Prevent Post-cardiotomy Delirium
The goal of this follow-on pilot randomized clinical trial is to obtain additional preliminary data to inform a larger, adequately powered phase 2b trial of daridorexant for the prevention of postoperative delirium after heart…
- Trial name
- NCT07217912
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
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