Clinical trials: Post-operative Cardiac Surgery
Delirium, Postoperative Cognitive Dysfunction
Dexmedetomidine to Reduce the Incidence of POCD After Open Cardiac Surgery
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Dexmedetomidine, Cognitive Impairment
- Trial name
- NCT03480061
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Sunnybrook Health Sciences Centre
Thoracic Surgery
Positive Expiratory Pressure With Blow-bottle Device Versus EPAP After Postoperative Cardiac Surgery
Cardiac surgery is a recommended therapeutic option as a form of secondary prevention for the treatment of cardiovascular diseases, but may present postoperative alterations such as reduction of pulmonary volumes and flows…
- Trial name
- NCT03639974
- Testing
- PEP in a blow-bottle device, EPAP, conventional physiotherapy
- Where
- Brazil
- Volunteers
- 163 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Cardiac Surgery
Transversus Thoracis Plane Block Versus Parasternal Intercostal Nerve Plane Block for Cardiac Surgery
Traditionally postoperative pain management after cardiac surgery has been based on opiate analgesics. However, opiates have some undesirable dose-related side-effects such as nausea, constipation, vomiting, dizziness, mental…
- Trial name
- NCT06155097
- Testing
- transversus thoracis muscle plane block (TTP), parasternal intercostal nerve block (PSI block)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Zagazig University
Delirium
Delirium and EuroSCORE II in Cardiac Surgery
The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery.
- Trial name
- NCT05218720
- Testing
- EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Heart Block After Surgery
Rhythm Disturbances After Ventricular Septal Defects
We would like to conduct a retrospective chart review examining the incidence of surgical heart block in children treated in the Cardiac Service Line at Children's Healthcare of Atlanta.
- Trial name
- NCT00208624
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Diastolic Dysfunction, Heart Failure
Assessment of Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery
Patients scheduled for Thoracic Endovascular Aortic Repair (TEVAR) surgery will have transthoracic echocardiography evaluation of left ventricle diastolic function during the perioperative period.
- Conditions
- Diastolic Dysfunction, Heart Failure, Aneurysm Aortic
- Trial name
- NCT03534440
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Warsaw
Cardiac Surgery, Dyspnea
Respiratory Physiotherapy and PMR After Cardiac Surgery
This study aims to evaluate the effects of respiratory physiotherapy combined with progressive muscle relaxation exercises on dyspnea, anxiety, hemodynamic status, and delirium symptoms in patients after cardiac surgery.
- Conditions
- Cardiac Surgery, Dyspnea, Anxiety, Delirium
- Trial name
- RESP-PMR (NCT07542691)
- Testing
- Respiratory Physiotherapy, Progressive Muscle Relaxation, Routine Care
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Istanbul Aydın University
Coronary Artery Disease, Coronary Artery Stenoses
Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride
The aim of this study is to evaluate the analgesic efficacy and safety of wound infiltration with liposomal bupivacaine (LB) in patients undergoing cardiac surgery with sternotomy and cardiopulmonary bypass (CPB) and compare it…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenoses, Valve Regurgitation, Mitral, Valve Regurgitation, Tricuspid
- Trial name
- NCT03270514
- Testing
- Exparel Injectable Product, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kathirvel Subramaniam
Myocardial Injury, Cardiac Surgery
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
The study aimed to evaluate the combined effects of cyclosporine and remote ischemic preconditioning on MDA, calcium cytosol concentration, and mitochondrial edema in tetralogy Fallot patients undergoing corrective surgery.
- Trial name
- NCT05691764
- Testing
- Cyclosporin, remote ischemic preconditioning
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Open Heart Surgery Patients
Patient Education by Mobile Application
Cardiovascular diseases are among the important health problems that cause mortality and morbidity both in our country and in the World (Sidar vd 2013).
- Trial name
- NCT05094063
- Testing
- patient education by mobile application
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Betul Zeynep Yildiz
Metabolic Acidosis
Intraoperative Cell Salvage and Postoperative Acidosis
Metabolic acidosis is a common complication that patients experience in the early postoperative period following cardiac surgery.
- Trial name
- NCT02800343
- Testing
- routine administration of 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Edinburgh
Pain
Pain Therapy After Elective Cardiac Surgery
The purpose of this study is to determine generation of a target controlled infusion model for the patient controlled analgesia with the strong analgesic, hydromorphone, after planned open heart surgery, during which the strong…
- Trial name
- PKPDHM-001 (NCT01490268)
- Testing
- Sufentanil, Hydromorphone
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Delirium
Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients
To evaluate the relationship between abnormal protein or metabolite expression levels in peripheral blood and postoperative delirium in elderly patients undergoing cardiac surgery.
- Trial name
- NCT06194474
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Jining First People's Hospital
Postoperative Complication, Respiratory Complications
Real-time Evaluation and Continuous Observation of Vital Signs for Enhanced Recovery: a Study for the Early Identification of Complications in the Surgical Ward Following Surgery in Patients Not Eligible for Intensive Care Admission.
This study aims to evaluate whether continuous vital sign monitoring with wearable devices can help detect postoperative complications in surgical ward earlier than standard hospital monitoring.
- Conditions
- Postoperative Complication, Respiratory Complications, Cardiac Complications
- Trial name
- RECOVER (NCT07729891)
- Testing
- Continuous vital sign monitoring with Portrait Mobile in surgical ward
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation
The Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery-Extended Follow-Up
The purpose of the Effect of Posterior Pericardiotomy on the Incidence of Atrial Fibrillation After Cardiac Surgery (PALACS, NCT02875405) trial was to determine if performing posterior left pericardiotomy at the time of cardiac…
- Trial name
- PALACS-EF (NCT05903222)
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Weill Medical College of Cornell University
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Postoperative Cardiac Complication
Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery
Cardiac arrythmias are the most common cardiac complications after thoracic surgery. They are made primarily of postoperative atrial fibrillation (POAF).
- Trial name
- CelDilPreCA (NCT03752931)
- Testing
- Celiprolol, Diltiazem
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Abderrahmane Mami Hospital
Opioid Use, Pain, Postoperative
ESP Block in Pediatric Patients for Postoperative Analgesia
Pediatric cardiac surgery is associated with moderate to severe postoperative pain that is related to median sternotomy. In a fast-track protocol, used in modern-day cardiac surgical care, early extubation may be facilitated by…
- Conditions
- Opioid Use, Pain, Postoperative, Quality of Life
- Trial name
- ESP1 (NCT03627897)
- Testing
- Bupivacain, saline
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
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