Clinical trials: Post-operative Cardiac Surgery
Surgical Site Infections
Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.
- Trial name
- MIR-CABG (NCT01949935)
- Testing
- Mupirocin
- Where
- Canada
- Volunteers
- 974 people
- Sponsor
- Horizon Health Network
Postoperative Delirium (POD), Postoperative
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery
A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative…
- Conditions
- Postoperative Delirium (POD), Postoperative, Anxiety, Depression
- Trial name
- NCT07476742
- Testing
- Active taVNS
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Chinese PLA General Hospital
Cardiorespiratory; Insufficiency, Due to A Procedure, Long-Term, Cardiac Surgery
Changes in Fitness and Strength in Postoperative Cardiac Patients Undergoing Exercise Therapy: Biological and Functional Mechanisms of Recovery
This study seeks to determine the biological, physiological and psychological effects of supervised exercise programs in patients surviving open heart surgery.
- Trial name
- NCT04903691
- Testing
- Cardiac Exercise Program
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Yale University
Cardiac Surgery and Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery
Many patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00334191
- Testing
- Sodium Bicarbonate
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Austin Health
Heart Diseases, Death
Registry for the Improvement of Postoperative OutcomeS in Cardiac and Thoracic surgEry
The registry for the improvement of postoperative outcomes in cardiac and thoracic surgery aims to prospectively collect data in order to test the association between various preoperative and per-operative variables ; and several…
- Conditions
- Heart Diseases, Death, Postoperative Complications, Cardiac Complication
- Trial name
- RIPOSTE (NCT03209674)
- Testing
- Cardiothoracic surgery
- Where
- France
- Volunteers
- 8,000 people
- Sponsor
- CMC Ambroise Paré
Delirium - Postoperative, Agitation
Responsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery
The goal of this clinical trial is to learn if a novel device (MindfulGarden) is beneficial in a population of patients undergoing cardiac surgery.
- Conditions
- Delirium - Postoperative, Agitation, Anxiety, Cardiac Surgery Recovery
- Trial name
- RESPITE (NCT07051096)
- Testing
- A novel device developed providing nature-driven responsive imagery that responds to the patient's physiological to distract, engage, and de-escalate behaviours of delirium., Routine post-operative management and standard delirium reduction measures.
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Pain, Postoperative
Erector Spinae Plane Block in Minimal Invasive Cardiac Surgery
Studying the effect of erector spinae plane block in patients undergoing minimal invasive cardiac surgery.
- Trial name
- NCT03825068
- Testing
- ESP Block, general anesthetic
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Surgical Site Infection, Antibiotic Prophylaxis
The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.
This study will seek to describe current practice of antibiotic prophylaxis to identify the effect of appropriate perioperative antimicrobial coverage - specifically regarding timing, dose adjustments, and redosing - on surgical…
- Trial name
- NCT03982810
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Heart Valve Diseases
Interdisciplinary Perioperative Care in Minimally-invasive Heart Valve Surgery
Valvular heart diseases are among the most common cardiac pathologies in adult patients in Germany. Currently, the process of care before, during and after heart valve surgery does not follow a standardized and interdisciplinary…
- Trial name
- INCREASE (NCT04977362)
- Testing
- Enhanced Recovery After Surgery, Treatment as Usual
- Where
- 2 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Anesthesia, General
The Effect of BIS-guided Propofol Induction on Hemodynamic Response in Patients With Cardiac Risk.
Anesthesia induction will be started by monitoring ECG, non-invasive artery monitoring, peripheral oxygen saturation and BIS for all patients who are taken to the operating room without sedation.
- Trial name
- NCT04729465
- Testing
- Propofol, Bispectral Index Monitor
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Postoperative Cognitive Dysfunction, Depressive Symptoms
Perioperative Cognitive Trajectories in Deferred Surgery (CoTELE-SURGE)
Cognition is the way people use their brains to think, understand, remember and make decisions. Cognitive changes are often seen even up to 1 year after surgery.
- Conditions
- Postoperative Cognitive Dysfunction, Depressive Symptoms, Postoperative Pain
- Trial name
- CoTELE-SURGE (NCT04787536)
- Testing
- Non-cardiac surgery
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Cardiac Complication, Postoperative Complications
Remote Electrocardiographic (ECG) ST-Monitoring (PROSE 3)in Post-op Patients
In moderate to high risk patients, cardiovascular complications after surgery account for almost 60% of death after surgery. This study will randomize 140 patients into routine postop care with Holter monitoring versus routine…
- Trial name
- PROSE 3 (NCT01423136)
- Testing
- Remote ECG monitoring Spacelab SL 1050
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- Ottawa Hospital Research Institute
Pain Measurement, Chronic Pain
Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System
Chronic postsurgical pain (CPSP) remains a significant clinical and public health challenge despite major advances in surgical and anesthetic techniques.
- Conditions
- Pain Measurement, Chronic Pain, Cardiac Implantable Electrical Devices, Neuropathic Pain
- Trial name
- PAIN-AID (NCT07322900)
- Volunteers
- 180 people
- Sponsor
- Istanbul University - Cerrahpasa
Surgical Blood Loss, Surgical Complication
Usability of Pericardial Flushing with the Haermonics Pure System After Cardiac Surgery
The goal of this clinical trial is to evaluate the usability of the Haermonics Pure system in patients undergoing a cardiac surgery procedure with the use of cardiopulmonary bypass.
- Trial name
- USEPURE (NCT06521164)
- Testing
- Haermonics Pure system
- Volunteers
- 65 people
- Sponsor
- Haermonics BV
Coronary Heart Disease (CHD)
Continuous Comprehensive Nursing for Post-CABG Recovery
This study evaluates the effectiveness of a continuous comprehensive nursing (CCN) system compared to routine care for patients after coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT07062432
- Testing
- Continuous Comprehensive Nursing System, Routine Postoperative Care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Hospital of Hebei Medical University
Drug Related Problems, Clinical Pharmacy
RISK ANALYSIS AND MANAGEMENT FOR MEDICATION OPTIMIZATION IN THE PREOPERATIVE AND POSTOPERATIVE PERIOD OF CARDIAC SURGICAL PATIENTS
Optimal perioperative and long-term success in cardiac-surgery require precise management of drug treatment. This study was aimed to determine prevalence, types and associated factors of drug related problems (DRPs) at both…
- Conditions
- Drug Related Problems, Clinical Pharmacy, Cardiac Surgery, Risk Assesment
- Trial name
- NCT05210335
- Testing
- Clinical pharmacist's recommendation to physicians about drug related problems
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Hypoplastic Left Heart, Tetralogy of Fallot
Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery
This study is being conducted to determine what dexmedetomidine does to the body and in turn, what how the body handles the medication.
- Conditions
- Hypoplastic Left Heart, Tetralogy of Fallot, Tricuspid Atresia
- Trial name
- InfantDex (NCT00573066)
- Testing
- Dexmedetomidine
- Volunteers
- 56 people
- Sponsor
- Athena Zuppa
Perioperative and Postoperative Hyperglycemia, Tight Glycemia Control
Perioperative Versus Postoperative Glycemia Control in Cardiac Surgery Patients
It is known that acute stress of organism often leads to hyperglycemia even in nondiabetic patients. It is also known that pathophysiological mechanisms: enhanced gluconeogenesis, impaired insulin secretion and decreased insulin…
- Trial name
- NCT01548963
- Testing
- Intensive glycemia control
- Where
- Czechia
- Volunteers
- 2,384 people
- Sponsor
- Charles University, Czech Republic
Ventilator-associated Pneumonia
Prevention Ventilator Associated Pneumonia
The objective of the investigators work was to evaluate the impact of 4 sequentially implemented measures for preventing VAP in a major heart surgery ICU.
- Trial name
- REINA (NCT02060045)
- Testing
- Bundle implementation
- Where
- Spain
- Volunteers
- 1,534 people
- Sponsor
- Maria Jesus Perez
Valve Heart Disease, Coronary Artery Disease
Post-Operative Myocardial Incident & Atrial Fibrillation
To explore predictors of major cardio-vascular events after cardiac surgery and trans-catheter valve implantation with a specific interest in studying mechanisms linking pre-operative leukocyte, fat and myocardial phenotypes with…
- Trial name
- POMI-AF (NCT03376165)
- Where
- France
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Lille
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