Clinical trials: Post-operative Cardiac Surgery
Coronary Artery Disease, Pain, Postoperative
Parasternal Nerve Block in Cardiac Patients
Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics.
- Trial name
- NCT01826851
- Testing
- Exparel
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Peter A Knight
Disorder; Heart, Functional, Postoperative, Cardiac Surgery
Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery
In 2019, the Enhanced Recovery After Surgery (ERAS) Society published recommendations for perioperative care in cardiac surgery.
- Trial name
- ERASCs (NCT05225272)
- Testing
- Enhanced Recovery Program for on-pump cardiac surgery
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Atrial Fibrillation
Study of T3 on the Incidence of Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The purpose of this project is to see whether treatment with a thyroid hormone, called triiodothyronine or T3, following open heart surgery reduces the risk of developing atrial fibrillation.
- Trial name
- NCT00289367
- Testing
- Triiodothyronine
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Northwell Health
Cardiac Surgery, Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery Study
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- Bic-MC (NCT00672334)
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Austin Health
Ischemia-reperfusion Injury.
The Safety of Vardenafil in Patients Undergoing Cardiac Surgery
The purpose of this study is to evaluate the safety of vardenafil in cardiac surgery patients.
- Trial name
- NCT01260285
- Testing
- Vardenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- McGuire Research Institute
Postoperative Cognitive Disorders
Impact of Combined PSi + NIRS Monitoring in the Prevention of Postoperative Cognitive Disorders in Cardiac Surgery.
Advances in cardiac medicine and anesthesia have made it possible to expand the indications for open heart surgery to increasingly older and more complex patients.
- Trial name
- NCT07267416
- Testing
- NIRS (Near Infrared Spectroscopy), SedLine®
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
Nursing Caries, Ambulation Difficulty
Early Mobilization in Cardiac Surgery
This study was planned to determine the mobilization process and factors affecting this process in patients who underwent open heart surgery and were admitted to the cardiovascular surgery intensive care unit.
- Trial name
- NCT06193447
- Testing
- None intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Surgery, Cardiac
Incidence of Postoperative Persistent Diaphragmatic Dysfunctions in Cardiac Surgery
Postoperative respiratory complication is a common complication that occurs in 6% of patients after cardiac surgery and increases morbidity and mortality and hospital length of stay.
- Trial name
- INDYD (NCT04276844)
- Testing
- Ultrasonography using the two-dimensional (2D) mode, Respiratory Functional Explorations
- Where
- France
- Volunteers
- 157 people
- Sponsor
- CMC Ambroise Paré
Delirium - Postoperative, Sleep Problems
Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Cardiac Surgery Patients
This study is titled "Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Adult Cardiac Surgery".
- Trial name
- NCT07588178
- Testing
- This is a observational study and there is no intervention.
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Yan Fuxia
Postoperative Complications, Heart Diseases
Detection of Right Ventricular Dysfunction by Portal Vein Doppler After Cardiac Surgery
Right ventricular (RV) failure after cardiac surgery is associated with morbidity and mortality, but is hard to diagnose with conventional echocardiographic means.
- Conditions
- Postoperative Complications, Heart Diseases, Heart Failure, Heart Valve Diseases
- Trial name
- DVDDP (NCT04890860)
- Testing
- cardiac surgery involving mitral or tricuspid valve repair procedure, with cardiopulmonary bypass
- Where
- France
- Volunteers
- 70 people
- Sponsor
- CMC Ambroise Paré
Intensive Care Unit Delirium
Dexmedetomidinine in the Prevention of Postoperative Delirium in the Intensive Care Unit After Cardiac Surgery
This is a prospective, randomized, single blinded, controlled clinical trial designed to compare the clinical effects of sedation with dexmedetomidine versus propofol in patients undergoing cardiac surgery.
- Trial name
- NCT05849597
- Testing
- Dexmedetomidine, Propofol
- Where
- Serbia
- Volunteers
- 200 people
- Sponsor
- University of Novi Sad
CABG, Cardiac Anesthesia
Impact of the Cardiopulmonary Bypass and Cross-Clamp Time Ratio on Postoperative Outcomes in Open Heart Surgery: A Prospective Observational Analysis
This study aims to investigate the relationship between the ratio of cardiopulmonary bypass (CPB) time to cross-clamp (CC) time and postoperative complications in open heart surgery.
- Conditions
- CABG, Cardiac Anesthesia, Cardiac Surgery Prognosis, Bypass Complication
- Trial name
- NCT06873620
- Where
- Turkey (Türkiye)
- Volunteers
- 348 people
- Sponsor
- Ahmet Yuksek
Postoperative Period, Physical Therapy Modalities
Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery
The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is…
- Conditions
- Postoperative Period, Physical Therapy Modalities, Continuous Positive Airway Pressure, Respiratory Function Tests
- Trial name
- PRO-LUNGHS (NCT06611527)
- Testing
- PS+PEEP group, CPAP group
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Federal University of São Paulo
Acute Aortic Dissection, Surgery (Cardiac)
Immune-Inflammatory Markers in Aortic Dissection
Identifying early on which patients with acute aortic dissection require closer monitoring may help with care planning. If simple, inexpensive values obtained from routine blood tests can provide additional information for…
- Conditions
- Acute Aortic Dissection, Surgery (Cardiac), Systemic Immune-inflammation Index, Postoperative Death
- Trial name
- NCT07683260
- Where
- Turkey (Türkiye)
- Volunteers
- 127 people
- Sponsor
- Bursa City Hospital
Acute Normovolemic Hemodilution, Cardiac Surgery
Impact of Pleth Variability Index-Guided Acute Normovolemic Hemodilution on Intraoperative Fluid Management and Postoperative Complications in Cardiac Surgery
Acute normovolemic hemodilution (ANH) is a widely used blood conservation strategy in cardiac surgery aimed at reducing intraoperative blood loss and the need for allogeneic blood transfusion.
- Conditions
- Acute Normovolemic Hemodilution, Cardiac Surgery, Postoperative Complication, Pleth Variability Index
- Trial name
- NCT07466082
- Testing
- acute normovolemic hemodilution, PVI dependant acute normovolemic hemodilution
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa City Hospital
Postoperative Cognitive Dysfunction
Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery
Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life.
- Trial name
- NCT07681063
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
C.Surgical Procedure; Cardiac, Right-Sided Heart Failure
Evaluation of Monitoring TECHNOlogies in the PERI-OPerative Care of Cardiac Surgical Patients
The purpose of this prospective observational cohort study is to evaluate multimodal monitoring technologies in the perioperative care of cardiac surgical patients.
- Conditions
- C.Surgical Procedure; Cardiac, Right-Sided Heart Failure, Acute Kidney Injury, Respiratory Insufficiency
- Trial name
- TechnoPeriOp (NCT02658006)
- Testing
- Cardiac surgery
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Respiration, Artificial, Positive-Pressure Respiration
VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU
Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU).
- Conditions
- Respiration, Artificial, Positive-Pressure Respiration, Postoperative Complications (Cardiopulmonary), Postoperative Complications
- Trial name
- VENTICRIT (NCT07646249)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva
Pain, Post Operative Analgesia
The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in…
- Conditions
- Pain, Post Operative Analgesia, Opioid Consumption, Postoperative
- Trial name
- IMPALA ERAS (NCT07224711)
- Testing
- Lidocaine HCl 0.8% in D5W, Dextrose 5% in water
- Where
- United States
- Volunteers
- 2,290 people
- Sponsor
- Vanderbilt University Medical Center
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