Clinical trials: Post-operative Cardiac Surgery
Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery With Cardiopulmonary Bypass
Inhaled Nitric Oxide for Prevention of Postoperative AKI in High-Risk Cardiac Surgery Patients
The goal of this clinical trial is to learn if giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in patients who are at high risk of developing this complication.
- Trial name
- NCT07544147
- Testing
- Inhaled Nitric Oxide (iNO)
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Postoperative Cognitive Disorder, Glaucoma
Application of Innovative Non-Invasive Neuroprotective Technology in Cardiac Surgery and Ophthalmology
Postoperative cognitive dysfunction (POCD) and delirium (incidence up to 42 %) after cardiac surgery with cardiopulmonary bypass (CPB) are common postoperative complications that impair the patient's quality of life and increase…
- Trial name
- NCT04943458
- Testing
- Monitoring of cerebral autoregulation
- Where
- Lithuania
- Volunteers
- 270 people
- Sponsor
- Milda Svagzdiene
Atrial Fibrillation, Myocardium; Injury
Statin Therapy In Cardiac Surgery
The purpose of STICS trial (Statin Therapy In Cardiac Surgery) is to test whether perioperative treatment with Rosuvastatin 20 mg once daily prevents post-operative atrial fibrillation and reduces perioperative irreversible…
- Trial name
- STICS (NCT01573143)
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 1,922 people
- Sponsor
- University of Oxford
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
Cardiovascular Diseases
Application of Exercises Based on the Pilates in Coronary Artery Bypass Grafting
The major cause of mortality worldwide is due to cardiovascular diseases. A way to treat these diseases is coronary artery bypass grafting, one of the most common surgical procedures in the world.
- Trial name
- NCT02109055
- Testing
- Pilates, Conventional Physiotherapy
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Heart Injuries, Kidney Transplant; Complications
Perioperative Factors and Early Postoperative Kidney Graft Function Recovery
Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function…
- Trial name
- NCT06280898
- Testing
- Remote ischemic conditioning
- Where
- South Korea
- Volunteers
- 539 people
- Sponsor
- Seoul St. Mary's Hospital
Adverse Event, Physiotherapy
Adverse Events During Physiotherapy at Intensive Care Unit In Patients Undergoing Cardiac Surgery
This study aims to estimate the incidence of adverse events during physiotherapy at intensive care unit (ICU) in adult patients undergoing cardiac surgery and to identify predictors of those events.
- Conditions
- Adverse Event, Physiotherapy, Intensive Care Units, Cardiac Surgery
- Trial name
- Adephysio (NCT03552887)
- Testing
- Cardiac Surgery, Physiotherapy
- Volunteers
- 323 people
- Sponsor
- University of Sao Paulo General Hospital
Post Induction Hypotension, Postoperative Morbidity
Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery
This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for…
- Trial name
- NCT07488182
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Necmettin Erbakan University
Pain
Parasternal Nerve Block Using Bupivacaine for Postoperative Analgesia in Children Undergoing Cardiac Surgery
All pediatric patients who undergo cardiac surgery require analgesic medications for postoperative pain control and many require sedation to facilitate comfort with cares.
- Trial name
- NCT02512861
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Acute Kidney Injury, Pediatric Cardiac Surgery
The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following…
- Trial name
- NCT06710353
- Testing
- Albumin solution, Crystalloid solutions
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Seoul National University Hospital
Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
Prospective Validation of DL Model for Postoperative MACCE Prediction
This study aims to prospectively validate a deep learning model developed using retrospective data to predict major adverse cardiac and cerebrovascular events (MACCE) occurring within 30 days after non-cardiac surgery.
- Trial name
- NCT07054502
- Where
- South Korea
- Volunteers
- 7,000 people
- Sponsor
- Seoul National University Hospital
Preoperative Sleep Disorder, Preoperative Anxiety
Relationship Between Perioperative Related Factors and Inflammatory Markers and Postoperative Delirium in Elderly Patients With Non-cardiac Major Surgery
Perioperative neurocognitive impairment, including postoperative delirium (POD), is common in older patients after anesthesia and surgery and is associated with poorer short- and long-term outcomes, including worsening cognitive…
- Conditions
- Preoperative Sleep Disorder, Preoperative Anxiety, Inflammatory Reaction, Postoperative Delirium
- Trial name
- NCT05341531
- Testing
- elderly patients undergoing non-cardiac surgery
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Post Operative Patient, Patients Requiring PCA
Evaluation of EverOn™ System in Medical / Surgical Ward
The EverOn™ system developed by EarlySense, Ltd., the sponsor of this study, is intended to assist hospitals to better address and improve recognition and response to changes in a patient's condition.
- Conditions
- Post Operative Patient, Patients Requiring PCA, Respiratory Patients, Patients in Risk of Fall
- Trial name
- NCT00640718
- Where
- United States
- Sponsor
- EarlySense Ltd.
Vasoplegia
Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac Surgery
This is a prospective pilot study in which the effects of ascorbic acid administration are investigated in adult patients undergoing cardiac surgical procedures requiring cardiopulmonary bypass (CPB).
- Trial name
- NCT03744702
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Monitored Anesthesia Care, Cardiac Surgery
Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass
Though Cardiac surgery under cardiopulmonary bypass (CPB) under epidural anesthesia in conscious patients is associated with increased risk of epidural hematoma.
- Conditions
- Monitored Anesthesia Care, Cardiac Surgery, Postoperative Recovery
- Trial name
- NCT05011617
- Testing
- Non-intubation and monitoring anesthesia care (MAC)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- ShuGuang Hospital
Older Patients, Surgery
Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery
Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse outcomes.
- Conditions
- Older Patients, Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT07576517
- Testing
- Dex-Esk, Active tDCS
- Where
- 6 sites in China
- Volunteers
- 1,996 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Post-operative Cardiac Surgery
Early Cardiac Extubation After Cardiac Surgery
The management of heart valve disease is constantly evolving over time. The minimally invasive approach (mini-thoracotomy and J-hemisternotomy) is one of the major surgical evolutions.
- Trial name
- NCT05050435
- Testing
- Early extubation
- Where
- Belgium
- Volunteers
- 500 people
- Sponsor
- University of Liege
Cardiac Surgery, Coronary Artery Bypass Grafting
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
Respiratory dysfunction following cardiac surgery is well documented and due in part to the location of the incision and nature of the surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Chronic Obstructive Pulmonary Disease (COPD), Older Adults
- Trial name
- NCT02732574
- Testing
- Oscilatory Positive Expiratory Pressure (OPEP) device
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Atrial Fibrillation (AF), Hypomagnesemia
Postoperative Incidence of Atrial Fibrillation Following Cardiac Surgery
Introduction: Postoperative atrial fibrillation is one of the most frequent complications in cardiac surgery, with an expected incidence of more than 50% following valve surgery.
- Conditions
- Atrial Fibrillation (AF), Hypomagnesemia, Cardiac Surgery
- Trial name
- NCT06855550
- Where
- Colombia
- Volunteers
- 435 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
Failed Back Surgery Syndrome
HRV in Patients Treated With Spinal Cord Stimulation
This study is an observatory single center study investigating heart rate variability during on and off states of the spinal cord stimulator, in patients with failed back surgery syndrome.
- Trial name
- NCT03768791
- Testing
- SCS is switched off, SCS is switched on
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Moens Maarten
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