Clinical trials: Post-operative Chronic Pain
Chronic Post-surgical Pain
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain
This pilot research study is being performed to learn more about pain and look at how pain changes brain chemistry and function. The research team would like to learn new information to better control chronic pain after surgery.
- Trial name
- NCT04681183
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Arthroscopic Rotator Cuff Repair (ARCR), Postoperative Pain
Tapentadol vs Tramadol in Arthroscopic Rotator Cuff Repair
Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Arthroscopic Rotator Cuff Repair Surgery.
- Conditions
- Arthroscopic Rotator Cuff Repair (ARCR), Postoperative Pain, Chronic Pain
- Trial name
- NCT07779473
- Testing
- Tramadol, Tapentadol
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- University of Thessaly
Hypertension
Postoperative Pain and Angiotensin II Receptor Antagonists
An angiotensin II type 2 receptor (AT2R) antagonist has been assessed for its efficacy in neuropathic pain with promising results.
- Trial name
- PP&ARA (NCT02513979)
- Testing
- Angiotensin type II receptor antagonists
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens
Postoperative, Acute Pain
TEAS-induced Analgesia: Dual vs Single Acupoints
The purpose of this study is to evaluate the effects of transcutaneous electric acupoint stimulation(TEAS) at single acupoint or dual acupoints on opioid consumption and postoperative pain in patients undergoing radical mastectomy
- Conditions
- Postoperative, Acute Pain, Chronic Pain
- Trial name
- TADS (NCT02543580)
- Testing
- transcutaneous electric acupoint stimulation, electrode attached but no stimulation
- Where
- China
- Volunteers
- 153 people
- Sponsor
- Xijing Hospital
Pain, Postoperative, Neuropathic Pain
Persistent Pain After Laparoscopic Inguinal Hernia Repair
Describe and characterizes laparoscopic postherniotomy patients with persistent moderate/severe pain affecting every day activities - including detailed quantitative sensory assessment
- Conditions
- Pain, Postoperative, Neuropathic Pain, Postherniotomy Pain
- Trial name
- NCT01085110
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Postoperative Pain
Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms
The treatment of postoperative pain continues to be inadequate in the investigators practice setting. Inadequate pain treatment not only contributes to postoperative complications in the short term but can also be a factor that…
- Trial name
- NCT01510496
- Testing
- Inguinal herniorraphy., Hysterectomy., Thoracotomy .
- Where
- 26 sites in Spain
- Volunteers
- 3,979 people
- Sponsor
- Fundacion IMIM
Chronic Postsurgical Pain
Effectiveness of Myofascial Release in Patients With Chronic Post Sternotomy Pain Syndrome
The main aim of this study is to investigate the effectiveness of Myofascial release in patients with chronic sternotomy pain.
- Trial name
- NCT06630208
- Testing
- Myofascial release, Breathing exercises, Pharmacological treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Post Operative Pain, Oxycodone
Effects of Oxycodone Combined With Pregabalin on Chronic Postsurgical Pain in Spinal Surgery
Chronic postoperative pain is one of the common perioperative complications, which seriously affects the prognosis of patients. Currently, no specific perioperative pain management strategy has been found to be effective in…
- Conditions
- Chronic Post Operative Pain, Oxycodone, Pregabalin, Postoperative Complications
- Trial name
- NCT05795478
- Testing
- Oxycodone and Pregabalin, Pregabalin and NS
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Beijing Tiantan Hospital
Chronic Post Operative Pain
Cytokine Alterations and Chronic Post-Surgical Pain
Chronic Post-Surgical Pain (CPSP) is a condition that involves experiencing pain and/or discomfort that lasts for more than 3 months following surgery without any explainable cause of this pain such chronic infection or pain…
- Trial name
- NCT06418295
- Testing
- Unilateral thoracotomy
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Pain
Incidence and Associated Factors of Persistent Postoperative Incision Scar Pain Following C/s in Mulago Hospital
prospective cohort study of women who underwent caesarean section in mulago hospital. followed up for 2 months and assessed for development of persistent post operative pain at the incision site and its effect on quality of life.
- Trial name
- PPOPinC/S (NCT03269188)
- Volunteers
- 277 people
- Sponsor
- Makerere University
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Pulmonary Dysfunction, Median Sternotomy Recovery
FROST-STERN Trial: A Trial of Intraoperative Cryoablation for Post Operative Pain Management After Full Sternotomy
Background and Rationale: Open-heart surgery via a median sternotomy is associated with severe acute postoperative pain. This pain can impair a patient's ability to take deep breaths and cough effectively which increases the risk…
- Conditions
- Pulmonary Dysfunction, Median Sternotomy Recovery, Postoperative Pain
- Trial name
- FROST-STERN (NCT07637370)
- Testing
- Intercostal Nerve Cryoablation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
Postoperative Pain, Satisfaction with Care
Thoracic Spinal Versus Thoracic Epidural Anesthesia for Patients with Chronic Obstructive Pulmonary Disease Undergoing Supine Percutaneous Nephrolithotomy for Management of Renal Stones.
Owing to the elevated risk of perioperative comorbidities, chronic obstructive and restrictive pulmonary disorders can be a challenging task for the anesthetist.
- Trial name
- NCT06663488
- Testing
- Thoracic epidural anesthesia, Thoracic spinal anesthesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Chronic Pain, Sciatica
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
The primary objective is to demonstrate the safety and efficacy of a non-awake implantation method (EMG neuromonitoring) of a SCS paddle lead as compared to an awake implantation method (with local anesthesia and patient…
- Conditions
- Chronic Pain, Sciatica, Failed Back Surgery Syndrome
- Trial name
- NAPS (NCT02284542)
- Testing
- Awake, Non-Awake
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Chronic Pain, Acute Pain, Cotinine, Hysterectomy
The Correlation Between Cotinine and Postoperative Acute and Chronic Pain After Hysterectomy
It is known that there is an association between smoking and acute/chronic pain. But it is so difficult to assess this relation with asking questions to the patients in the preoperative period.
- Trial name
- NCT04274673
- Testing
- measuring cotinine level
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people
- Sponsor
- Mustafa Kemal University
Perioperative Pain Management
Effects of Different Doses of Intravenous Lidocaine Infusion on Peri-operative Pain and Incidence of Postoperative Chronic Pain Within ERAS Protocols, a Dose Finding Study.
This study aimed To investigate the effects of different doses of Intraoperative intravenous lidocaine infusion on intraoperative opioid consumption, perioperative pain control and incidence of postoperative chronic pain.
- Trial name
- NCT06431165
- Testing
- Lidocaine IV
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Pain, Video-Assisted Thoracoscopic Surgery
US-Guided SAPB Versus ESPB on Acute and Chronic Pain After VATS
Postoperative acute and chronic pain is frequently observed in patients undergoing video assisted thoracoscopic surgery (VATS). This prolongs the discharge time of patients and increases the frequency of postoperative pulmonary…
- Conditions
- Postoperative Pain, Video-Assisted Thoracoscopic Surgery, Serratus Anterior Plane Block, Erector Spinae Plane Block
- Trial name
- NCT05160961
- Testing
- Serratus anterior plane block, Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Breast Cancer, Anesthesia
Opioid-free Anaesthesia in Breast Cancer Surgery
Background: Various analgesic modalities are adopted for perioperative analgesia in breast cancer surgeries. Opioid-free and opioid-sparing techniques are gaining popularity due to the lack of opioid-dependent undesirable…
- Conditions
- Breast Cancer, Anesthesia, Pain, Postoperative, Pain, Chronic
- Trial name
- NCT06404983
- Testing
- Opioid Free Anaesthesia (OFA), Conventional General Anaesthesia (CGA)
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Ioannina
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Joint Pain, Chronic Pain
Predicting Chronic Opioid Use Following Lower Extremity Joint Arthroplasty
Personalized medicine is a concept in which medical care is individualized to a patient based on their unique characteristics, including comorbidities, demographics, genetics, and microbiome.
- Conditions
- Joint Pain, Chronic Pain, Opioid Use
- Trial name
- NCT04974463
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of California, San Diego