Clinical trials: Post-operative Chronic Pain
Breast Cancer Patients With Chronic Pain After Surgery
Effect of Bupivacaine Liposome Anterior Serratus Deep Block on Chronic Pain After Breast Cancer Surgery: a Randomized Controlled Study
This study aims to investigate the effect and influence of liposome bupivacaine anterior serrat plane block on postoperative chronic pain in breast cancer patients, evaluate the therapeutic effect of liposome bupivacaine in…
- Trial name
- NCT06427044
- Testing
- Anterior serratus block group
- Where
- China
- Volunteers
- 143 people
- Sponsor
- Lu Hua
Hyperalgesia, Pain, Postoperative
Effects of Nefopam on Hyperalgesia After Cardiac Surgery
Postoperative pain after major surgery is consecutive not only to the nociceptive inputs coming from the surgical lesion, but also to peripheral and central neuronal sensitization.
- Conditions
- Hyperalgesia, Pain, Postoperative, Pain, Chronic Disease
- Trial name
- NefalCard (NCT00413257)
- Testing
- Nefopam, néfopam
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Chronic Postoperative Pain, Chronic Post-Sternotomy Pain
Parasternal Intercostal Nerve Block and Chronic Pain After Cardiac Surgery
Chronic post-sternotomy pain is a common but under-recognised complication of cardiac surgery, reported in roughly 11 to 56 percent of patients and capable of persisting for years after the operation.
- Conditions
- Chronic Postoperative Pain, Chronic Post-Sternotomy Pain, CABG, Sternotomy
- Trial name
- PINB-CPSP (NCT07818512)
- Testing
- Ultrasound-Guided Parasternal Intercostal Nerve Block, Bupivacaine 0.25%
- Volunteers
- 132 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Postoperative Delirium, Chronic Postsurgical Pain
Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Single-celled sequencing for evaluating differences in gene expression patterns in different cell types of the dynamics of a means of this research as a starting point, to study the postoperative delirium and chronic pain at the…
- Trial name
- NCT05572307
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Pain After Surgery, PSP
Intraoperative Bupivacaine Injection to Reduce Acute and Chronic Pain After TVT/TVT-O Surgery. Randomized Double-Blind Trial
This randomized, double-blind controlled trial will evaluate whether intraoperative injection of bupivacaine at the sling insertion site reduces postoperative pelvic and thigh pain in women undergoing TVT or TVT-O surgery for…
- Conditions
- Pain After Surgery, PSP, Chronic Pain Syndrome, Local Anesthesia Infiltration
- Trial name
- PAIN-TVT (NCT07429019)
- Testing
- Bupivacain (Postoperative)
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Pain Syndrome, Pain, Postoperative
The Impact of Pecs Blocks on Postmastectomy Pain Syndrome
The aim of the present study is to investigate the incidence of chronic pain following breast cancer surgery in Cyprus, discover its associated risk factors and explore the impact of Pecs Blocks on the appearance of post…
- Conditions
- Pain Syndrome, Pain, Postoperative, Chronic Pain, Breast Cancer
- Trial name
- NCT04586751
- Testing
- Pecs block, no Pecs block
- Where
- 3 sites in Cyprus, Greece
- Volunteers
- 64 people
- Sponsor
- Aretaieion University Hospital
Chronic Postoperative Pain
A Comparative Effect of Echogenic Needle for Nerve Block on Acute and Chronic Postoperative Pain
Surgical pain is a common complication after surgery, affecting patient recovery and treatment quality. >20% of patients suffer from chronic postoperative pain. China has >70 million surgeries yearly.
- Trial name
- NCT06281431
- Testing
- Echogenic nerve block needle, Non-echogenic nerve block needle
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation
This research aims to uncover the Mechanisms of pain relief through the FDA-cleared peripheral transcutaneous magnetic stimulation (pTMS) device by MagVenture.
- Trial name
- NCT07199361
- Testing
- Peripheral Transcutaneous Magnetic Stimulation from MagVenture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida International University
Pain
Pharmacogenetic Morphine Spine Study
The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children cope with pain and respond to pain medication.
- Trial name
- NCT01839461
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Pain, Postsurgical Pain
Safety, Tolerability, Effectiveness, and Pharmacokinetic Data in Opioid-experienced Children
The purpose of this study was to assess the safety and pharmacokinetics (single- and multiple-dose) of oxymorphone ER for the relief of moderate to severe pain in pediatric participants ages 7 - ≤17 years old requiring a…
- Trial name
- NCT04681027
- Testing
- Oxymorphone hydrochloride (HCl)
- Where
- 5 sites in United States
- Volunteers
- 15 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Pain, Postoperative, Chronic Pain
Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?
The recent increase in obesity has led to an increase in the need for bariatric surgery. In this group of patients the postoperative pain management is of vital importance.
- Trial name
- NCT02775474
- Testing
- Use of Intraoperative Intravenous Methadone, Use of Intraoperative Intravenous Fentanyl
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo General Hospital
Regional Anesthesia, Thoracic Surgery
Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery
The objective of the study is to compare the efficacy of the Serratus Anterior Plane block (SPB) realised in its deep plane, with a multi-holed catheter in place for twenty four hours, to a standard intravenous analgesia for…
- Conditions
- Regional Anesthesia, Thoracic Surgery, Post-operative Pain, Post-operative Chronic Pain
- Trial name
- Serrathos (NCT03277391)
- Testing
- Serratus anterior plane block, patient-controlled analgesia
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Université Libre de Bruxelles
Chronic Pain, Pain Measurement
Relationship of Intra-Epidermal Nerve Fibre Density (IENFD) and Structure to Chronic Post-Mastectomy Pain Syndrome (PMPS)
This is a retrospective, observational study which will utilise the Edinburgh Cancer Research Centre's Tissue Bank to provide samples for IENFD testing in those who have undergone mastectomy surgery for breast cancer.
- Conditions
- Chronic Pain, Pain Measurement, Mastectomy, Postoperative Pain
- Trial name
- NCT02919891
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Royal Infirmary of Edinburgh
Post-Operative Pain, Chronic
Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery
This study is a randomized study that compares two commonly used post-operative pain reducing techniques by measuring the level of pain and use of pain medication after knee surgery.
- Trial name
- NCT05004506
- Testing
- Adductor Canal Block, Intra-articular Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Pain, Intractable
OPTIONS Spinal Cord Stimulation Programming Parameters
The purpose of this study is to evaluate programming options in spinal cord stimulation for the management of chronic, intractable pain of the trunk and limbs.
- Trial name
- NCT02503787
- Testing
- Spinal Cord Stimulation (SCS)
- Where
- 11 sites in United States
- Volunteers
- 64 people
- Sponsor
- MedtronicNeuro
Failed Back Surgery Syndrome, Limb Ischemia
Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord Stimulaion
This observational multicenter study aims to evaluate the reliability and validity of the e-tool for selecting patients eligible for SCS for chronic pain caused by one of the four etiologies listed above in the experience of…
- Conditions
- Failed Back Surgery Syndrome, Limb Ischemia, Neuropathic Pain, Complex Regional Pain Syndromes
- Trial name
- E-TOOLSCS (NCT06229015)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Postoperative Cognitive Dysfunction
Preoperative Pain and POCD in Elderly Patients
The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.
- Trial name
- NCT03393676
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Breast Cancer, Postoperative Pain
Prediction of Pain After Breast Cancer Surgery With EEG
1. Rationale The inter-individual pain experience immediately after surgery is considerable. In addition, a number of patients develop chronic post surgery pain (CPSP).
- Conditions
- Breast Cancer, Postoperative Pain, Chronic Pain
- Trial name
- NCT01392248
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Maastricht University Medical Center
Chronic Pain, Wound Dehiscence
Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure
This randomized controlled trial aims to compare the outcomes of Polyglactin (Vicryl) versus Polypropylene (Prolene) sutures for rectus sheath closure in patients undergoing midline laparotomy.
- Conditions
- Chronic Pain, Wound Dehiscence, Surgical Site Infection (SSI), Incisional Hernia
- Trial name
- PolySuture (NCT07280975)
- Testing
- Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture
- Where
- Pakistan
- Volunteers
- 156 people
- Sponsor
- Lady Reading Hospital, Pakistan
Spinal Cord Injuries, Nerve Injury
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional…
- Conditions
- Spinal Cord Injuries, Nerve Injury, Pain, Postoperative, Post Herpetic Neuralgia
- Trial name
- NCT04144972
- Testing
- Medtronic Summit RC+S or Percept RC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco