Clinical trials: Post-operative Chronic Pain
Children, Postoperative Pain
Acupuncture for Tonsillectomy Pain
Pain after tonsillectomy can be severe and last ten days. Various new surgical instruments have been developed over the years in an attempt to reduce postoperative pain with mixed results and increased costs; no single…
- Conditions
- Children, Postoperative Pain, Tonsillar Hypertrophy, Obstructive Sleep Apnea
- Trial name
- NCT01389349
- Testing
- Acupuncture
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Children's ENT of San Diego, Inc.
Chronic Postoperative Pain
Validation of Predictive Scale of Chronic Postsurgical Pain
To asses the precision of a score to predict chronic post surgical pain in patients undergoing inguinal hernia repair, abdominal hysterectomy, vaginal hysterectomy and thoracotomy.
- Trial name
- NCT02991287
- Testing
- Inguinal hernia repair, Abdominal hysterectomy, Vaginal hysterectomy
- Where
- 21 sites in Spain
- Volunteers
- 1,040 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Scoliosis Correction, Postoperative Analgesia
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe postoperative acute pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT05718544
- Testing
- Esketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Peking University First Hospital
Pain, Postoperative, Scoliosis Idiopathic
Gabapentin and Chronic Post Surgical Pain
The purpose of this study is to investigate the effect of a common pain medication (gabapentin) on chronic postsurgical pain in pediatric patients who require surgery for idiopathic scoliosis.
- Trial name
- CPSP (NCT03867240)
- Testing
- Gabapentin
- Where
- United States
- Sponsor
- Emory University
Chronic Postoperative Pain
Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention
This study will test the null hypothesis that low-dose ketamine given peri-operatively will have no effect on the development of chronic post-surgical pain, in patients undergoing thoracotomy or video assisted thoracic surgery…
- Trial name
- NCT01296347
- Testing
- Ketamine
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Imperial College Healthcare NHS Trust
Pain, Postoperative, Pain, Acute
Intravenous Methadone in Perioperative Acute and Chronic Management in Chinese Adult Cardiac Surgical Patients
Despite modern day improvements in pain treatment and availability of different analgesic modalities, suboptimal postoperative pain control remains an issue in cardiac surgical patients.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Anesthesia
- Trial name
- NCT05913284
- Testing
- Methadone, Morphine
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Postoperative Pain, Chronic Pain
Preoperative Gabapentin for Chronic Pain After Thoracotomy (GABATHOMIE).
To assess the effects of prolonged preoperative gabapentin treatment (10 days) on chronic pain after thoracotomy.
- Trial name
- GABATHOMIE (NCT03158376)
- Testing
- Gabapentin
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Lille
Chronic Pain, Acute Pain
Pain Predict Genetics
Pain is the most frequent cause of suffering and disability in society. Despite considerable involvement of genetic factors in pain sensation and sensitivity, the individual genes involved remain largely unidentified.
- Trial name
- PPG (NCT02383342)
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Radboud University Medical Center
Breast Cancer, Pain
Chronic Pain in Women Who Have Undergone Surgery for Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Learning about chronic pain in women who have undergone surgery for breast cancer may help improve the quality of life for these patients and may help doctors plan the best treatment.
- Conditions
- Breast Cancer, Pain, Perioperative/Postoperative Complications
- Trial name
- NCT00971919
- Testing
- questionnaire administration, assessment of therapy complications, psychosocial assessment and care
- Where
- United Kingdom
- Volunteers
- 284 people
- Sponsor
- Aberdeen Royal Infirmary
Chronic Low Back Pain, Chronic Sciatica
A Zhineng Qigong Intervention for Patients With Chronic Low Back Pain and/or Leg Pain
The purpose of this study is to evaluate a Zhineng Qigong intervention for patients with chronic low back pain and/or leg pain, and to test feasibility aspects.
- Conditions
- Chronic Low Back Pain, Chronic Sciatica, Lumbar Spinal Stenosis, Lumbar Disc Herniation
- Trial name
- NCT04520334
- Testing
- Zhineng Qigong intervention
- Where
- 9 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- Lund University
Chronic Postherniotomy Pain
Predisposing Factors for Chronic Postherniotomy Pain
Chronic pain affects pain in 5-8% of patients more than a year after groin hernia repair. However no prospective study has investigated potential predisposing factors for development of pain, including genetic, psychosocial and…
- Trial name
- NCT00649142
- Testing
- Open sutured mesh repair, Laparoscopic mesh glue fixation
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 455 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
LUMBAR STENOSIS
Pain After Microsurgical Decompression
This prospective observational cohort study aims to determine whether a combination of preoperative clinical, psychological, sleep-related, inflammatory, genetic, and epigenetic factors can predict chronic postoperative pain 12…
- Trial name
- NCT07883694
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Aalborg University
Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Chitosan-Based, Gelatin Sponge and Non-absorbable Nasal Packing After Endoscopic Sinus Surgery
This single-centre prospective study compared three nasal packing materials used after endoscopic sinus surgery (ESS) in adults with chronic rhinosinusitis without nasal polyps: a chitosan-based bioresorbable pack (PosiSep X), an…
- Trial name
- ESSPACK-2024 (NCT07862283)
- Testing
- PosiSep X, Spongostan, Osseous polyvinyl alcohol sinus pack (EON Meditech)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Pain, Postoperative
Para-vertebral Dexmedetomidine and the Incidence of Postoperative Chronic Pain
Up to our knowledge there is no study focused upon the incidence of post VATS chronic pain when dexmedetomidine is used.
- Trial name
- NCT03632161
- Testing
- Dexmedetomidine, Bupivacaine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Osteoarthritis, Pain
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement…
- Conditions
- Osteoarthritis, Pain, Postoperative Pain, Surgery
- Trial name
- NCT03126279
- Testing
- Total Knee Replacement Surgery
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Low-back Pain, Postsurgical Pain
Postoperative Telehealth Mindfulness Intervention After Spine Surgery
Lumbar spine pain is the leading cause of years lived with a disability and affects over 50 million individuals in the United States.
- Conditions
- Chronic Low-back Pain, Postsurgical Pain, Opioid Use, Lumbar Spine Surgery
- Trial name
- NCT04648683
- Testing
- Individual telehealth mindfulness, Group telehealth mindfulness
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Thoracic Surgery, Videoassisted Thoracoscopic Surgery,One-lung Ventilation
The Impact of Video-assisted Thoracic Surgery and Regional Anaesthesia on Postoperative Opioid Consumption and Pain Scores
This present study aims is to compare the effects of ultrasound-guided paravertebral block, intertransverse process block, and erector spinae plane block on postoperative opioid consumption, and pain scores in patients undergoing…
- Conditions
- Thoracic Surgery, Videoassisted Thoracoscopic Surgery,One-lung Ventilation, Regional Anaesthesia, Postoperative Analgesia
- Trial name
- NCT07578545
- Testing
- Paravertebral block group, İntertransverse process block group, Erector spinae plane block group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Antalya Training and Research Hospital
Erector Spinae Plane Block, Pain Control
Intravenous(IV) vs. Erector Spinae Plane Blocks in Cardiac Surgery
Interfascial plane blocks have been developed for analgesia, among which the erector spinae plane (ESP) has gained popularity. The ESP block has been hypothesized to provide truncal analgesia by spread of local anesthetic into…
- Conditions
- Erector Spinae Plane Block, Pain Control, Post-Operative Pain, Chronic
- Trial name
- NCT04995497
- Testing
- Intravenous Administration of Lidocaine Post Cardiac Surgery, Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Archit Sharma
Neuropathic Pain, Chronic Postsurgical Pain
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
The prevalence of post-surgical lumbar neuropathic radiculopathy is approximately 30%. Poor response to the treatments recommended for neuropathic pain, namely antidepressants and/or gabapentinoids, requires the development of…
- Trial name
- NeuroPRF (NCT05196503)
- Testing
- Treatment
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Postoperative Pain, Chronic Pain
Safety, Tolerability, and Pharmacokinetics of HSK21542 in Healthy Volunteers
This is a A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of a kappa receptor agonist HSK21542 in Healthy Volunteers.
- Trial name
- NCT04110886
- Testing
- HSK21542
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd