Clinical trials: Post-operative Chronic Pain
Breast Neoplasms, Pain,Postoperative
Chlorhydrate of Ropivacaine and Breast Cancer Surgery
The aim of the study is to evaluate the effect of local anesthetic (chlorhydrate of ropivacaine) to prevent chronic pain after breast surgery for cancer.
- Trial name
- NCT00370240
- Testing
- Chlorhydrate de Ropivacaine
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Institut Curie
Pain, Breast Cancer
Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy
Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors.
- Trial name
- NCT00129597
- Testing
- ketalar
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Chronic Postoperative Pain
Placebo Effect In Spinal Cord Electrical Stimulation for Pain
Objective: To evaluate if spinal cord stimulation (SCS) performs better than placebo (no stimulation) in the long term to reduce persistent neuropathic leg pain refractory to medication and other conservative treatments in…
- Trial name
- PISCES (NCT06585033)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in Netherlands, Norway and 1 more
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Failed Back Surgery Syndrome
Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain
Spinal cord stimulation (SCS) has been used for over 40 years to treat neuropathic pain. Various clinical studies have shown a beneficial effect of SCS on pain in patients with Failed Back Surgery Syndrome (FBSS).
- Trial name
- NCT01096147
- Testing
- Spinal cord stimulation with eight polar electrode
- Where
- 8 sites in Belgium, Norway and 1 more
- Volunteers
- 80 people
- Sponsor
- Rik Buschman, PhD
Revision Spine Surgery, Fusion of Spine
Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery
To determine if a pre-operative ketamine infusion would provide a similar decrease in post-operative analgesic and opioid consumption as intra-operative ketamine, but expand the monitoring period through the post-operative phase…
- Conditions
- Revision Spine Surgery, Fusion of Spine, Cervical Fusion, Lumbar Fusion
- Trial name
- KIPSs (NCT06066879)
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AXIS Spine Center- a division of Northwest Specialty Hospital
Pain, Chronic, Knee Pain Chronic
Pain Reprocessing Therapy in Post-Operative Knee Pain
The goal of this clinical trial is to learn whether Pain Reprocessing Therapy (PRT) can help adults with knee pain after knee replacement surgery.
- Trial name
- REJOICE (NCT06800209)
- Testing
- Pain reprocessing therapy (PRT), Usual care
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Weill Medical College of Cornell University
Chronic Pain, Dexamethasone
Dexamethasone for Reduction of Post Thoracotomy Pain Syndrome
Post thoracotomy pain syndrome still affects 50% of patients after a thoracic surgery. Pathogenesis is unclear but there is growing evidence that neuro inflammation may play a significant role.
- Conditions
- Chronic Pain, Dexamethasone, Thoracic Surgery, Cytokines
- Trial name
- NCT02112864
- Testing
- Dexamethasone, Normal Saline
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Serratus Plane Block, Postoperative Hyperalgesia
Effect of Liposome Bupivacaine Serratus Plane Block on Postoperative Hyperalgesia and Chronic Post-surgical Pain in Patients Undergoing Radical Mastectomy
Radical mastectomy is currently the mainstream surgical treatment for breast cancer. Patients often experience significant postoperative pain, and some may develop chronic pain.
- Conditions
- Serratus Plane Block, Postoperative Hyperalgesia, Chronic Post-surgical Pain, Liposomal Bupivacaine
- Trial name
- NCT07289178
- Testing
- Serratus Plane block (single injection)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Postoperative Pain, Chronic Pain
Chronic Postoperative Pain After Laparoendoscopic Groin Hernia Repair
The study attempts to quantify the relative risks for chronic postoperative inguinal pain (CPIP) depending on different combinations of mesh and mesh fixation.
- Trial name
- NCT04838028
- Testing
- TEP, TAPP, Other or unspecified laparoendoscopic groin hernia repair
- Volunteers
- 15,360 people
- Sponsor
- Karolinska Institutet
Chronic Post-thoracotomy Pain, Neuropathic Pain
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
This study aims to evaluate the efficacy of ultrasound-guided Serratus Posterior Superior (SPS) block compared to surgeon-administered intercostal blockade in preventing chronic pain at 3, 6, and 12 months following…
- Conditions
- Chronic Post-thoracotomy Pain, Neuropathic Pain, Postoperative Pain, Acute
- Trial name
- NCT07436806
- Testing
- SPS block, Surgical Intercostal Blockade.
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Phantom Limb Pain
Controlled Study of Farabloc for Chronic Phantom Limb Pain Among Veteran Amputees
The primary purpose of this study is to determine if the group using Farabloc shows a greater reduction in pain levels than the group not using Farabloc at 6-week, 12-week and 1-month post treatment follow-ups.
- Trial name
- NCT00797849
- Testing
- Farabloc Limb Cover
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Southern California Institute for Research and Education
Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain
SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients
SPINE-RISK VE is a prospective multicenter cohort study designed to develop and internally validate a multimodal preoperative predictive model for Failed Back Surgery Syndrome (FBSS), now classified as Persistent Spinal Pain…
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain, Postoperative Pain, Lumbar Spine Surgery
- Trial name
- SPINE-RISK VE (NCT07693517)
- Testing
- SPINE-RISK VE multimodal preoperative assessment
- Where
- Venezuela
- Volunteers
- 150 people
- Sponsor
- juan jose valero quintero,MD
Breast Cancer, Postoperative Pain, Acute
Rhomboid Intercostal Plane Block on Chronic Pain Incidence and Acute Pain Scores After Mastectomy
Rhomboid intercostal block is used to block lateral cutaneous branches of intercostal nerves between T3 and T9 dermatomes. RIB has been reported to be successful in attenuating acute pain following breast surgeries.
- Conditions
- Breast Cancer, Postoperative Pain, Acute, Postoperative Pain, Chronic, Neuropathic Pain
- Trial name
- NCT06019325
- Testing
- RIB
- Where
- Turkey (Türkiye)
- Volunteers
- 254 people
- Sponsor
- Muğla Sıtkı Koçman University
MeSH C23.300.707.374.875, MeSH E01.370.388.250.520
Comparing Two Nerve Block Methods for Pain Relief in Laparoscopic Hernia Surgery
After inguinal hernia repair, patients having chronic pain approximately 20 percent. If patients don't have postoperatively acute pain, they will tend to have less chronic pain.
- Conditions
- MeSH C23.300.707.374.875, MeSH E01.370.388.250.520, MeSH E03.155.086.711, MeSH C23.550.767.700
- Trial name
- NCT07676123
- Testing
- Anterior Quadratus Lumborum Block, Ilioinguinal-Iliohypogastric Block
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara University
Postoperative Pain
Duloxetine vs Pregabalin for Thoracotomy Pain
This study investigates the effects of preoperative use of oral combination of duloxetine and Pregabalin in comparison with preoperative oral Pregabalin only in treatment of acute postoperative and prevention of chronic pain…
- Trial name
- NCT04782310
- Testing
- Pregabalin, Duloxetine
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Cairo University
Chronic Pain
Central Nervous System Amplification in Lumbar Failed Back Surgery Syndrome
The purpose of this study is to learn whether or not certain risk factors and patient characteristics are linked with and possibly can predict the development of chronic pain after lumbar spine surgery.
- Trial name
- NCT03444168
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cardiovascular Surgery, Regional Anaesthesia
Fascial Plane Blocks In Cardiac Surgery
The aim of the present study is to evaluate the effects of the recto-intercostal fascial plane block (RIFPB) or the rectus sheath block (RSB) combined with the pectoral-intercostal fascial plane block (PIFPB) on postoperative…
- Conditions
- Cardiovascular Surgery, Regional Anaesthesia, Postoperative Analgesia
- Trial name
- NCT07622823
- Testing
- PIFPB + RIFPB, PIFPB + RSB, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Antalya Health Sciences University
Persistent Postoperative Pain
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
Persistent postoperative pain is a substantial pain (scores 4-10 using a 0-10 numeric scale) that develops 3 months after surgery. Persistent postoperative pain can be a problem even in ambulatory surgery.
- Trial name
- AWA3PASIC (NCT06271174)
- Testing
- Carbocaine, Profofol and/or Suxaméthonium and/or Sévoflurane
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Nantes University Hospital