Clinical trials: Post-operative Complication
Pain, Postoperative
Evaluation of Preoperative N1539 in Colorectal Surgery
The primary objective of this study is to evaluate the safety and tolerability of preoperative dosing of N1539 30 mg in subjects undergoing colorectal surgery, including clinical laboratory tests, wound healing evaluation…
- Trial name
- NCT03323385
- Testing
- N1539
- Where
- 10 sites in United States
- Volunteers
- 57 people
- Sponsor
- Baudax Bio
Tonsillectomy
Celecoxib After Tonsillectomy
Tonsillectomy is one of the most common pediatric surgical procedures in the United States. Postoperative pain is substantial, with typical regimens employing narcotic derivatives and acetaminophen for 1-2 weeks after surgery.
- Trial name
- NCT02934191
- Testing
- Celecoxib, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Children's Hospital of Philadelphia
Traumatic Amputation
Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program
The purpose of this randomized control study is to determine if administering neuromuscular electrical stimulation (NMES) to the thigh muscles of a below the knee amputee is more effective than the current standard of care in…
- Trial name
- NCT00942890
- Testing
- NMES (EMPI 300PV stimulator) plus standard of care, TMARP standard of care
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Tennessee
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Pain, Postoperative
Effect of Ketamine on Analgesia Post-Cardiac Surgery
Randomized, controlled, double-blind pilot study evaluating the effect of an intraoperative infusion of intravenous Ketamine on the quantity of opioid consumed postoperatively in coronary artery bypass surgery patients receiving…
- Trial name
- NCT02925858
- Testing
- Normal Saline Flush, 0.9% Injectable Solution_#1, Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Jewish General Hospital
Bladder Cancer
Steps to Eliminate Postoperative Problems
Radical cystectomy with urinary diversion is associated with substantial perioperative morbidity, including deep venous thrombosis, prolonged ileus, and postoperative functional decline.
- Trial name
- STEPP (NCT02880176)
- Testing
- Financial Incentive to Increase Ambulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Pennsylvania
Nerve Block, General Anesthesia
Spinal Versus General Anesthesia With Popliteal and Adductor Canal Blocks for Ambulatory Foot and Ankle Surgery.
The purpose of this study is to determine if there is a difference in patient outcomes with general anesthesia versus spinal anesthesia when given in addition to popliteal and adductor canal nerve blocks for foot and ankle…
- Conditions
- Nerve Block, General Anesthesia, Spinal Anesthesia, Pain
- Trial name
- LMA vs Spinal (NCT02996591)
- Testing
- 25 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for popliteal nerve block, 10 mL of 0.25% bupivacaine plus 2 mg preservative-free (PF) dexamethasone / 30 ml for adductor canal nerve block, Midazolam, 2-5 mg IV + Glycopyrrolate, 0.1 mg IV + Ketamine, 10-20 mg + propofol as needed
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain
Adductor Canal Mid-thigh and Adductor Canal Distal Thigh: Is Cutaneous Sensory Blockade Similar Among Block Techniques?
This is a randomized noninferiority interventional study to determine the equivalence of two adductor canal block (ACB) methods: mid-thigh and distal thigh in patients undergoing medial foot, medial ankle, or medial leg surgery.
- Trial name
- NCT02788019
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pain, Postoperative, Numbness
Lidocaine Versus Bupivacaine in Orthognathic Surgery
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery.
- Conditions
- Pain, Postoperative, Numbness, Temperature Sensation, Perception of Touch
- Trial name
- NCT06450028
- Testing
- 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Urinary Retention
Treatment for Acute Postoperative Voiding Dysfunction
If patients are unable to have their foley catheter removed because their bladder is not emptying well, they may be eligible for study participation.
- Trial name
- PTNS (NCT01189136)
- Testing
- PTNS Active Treatment
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Total Knee Arthroplasty (Postoperative Pain), Total Hip Arthroplasty(Postoperative Pain)
Dose Dependent Effects of tDCS on Post-Operative Pain
The proper control of acute and chronic pain is one of the most important areas in health care. Despite the profound advances in neuroscience over the past 20 years, the investigators still largely use opiate narcotics, much as…
- Trial name
- tDCS-TKA (NCT02241967)
- Testing
- 4 Real sessions of Transcranial Direct Current Stimulation, 2 Real Sessions of Transcranial Direct Current Stimulation, 1 Real Session of Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Surgical Recovery, Pain, Postoperative
Oxidative Stress and Surgical Recovery
Chronic pain, functional impairment and slow rates of recovery are key issues for patients after surgery and trauma. No preventative strategy in current use unequivocally modifies these rates, and few novel approaches have been…
- Trial name
- NCT04732000
- Testing
- N-acetyl cysteine, Normal Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Postoperative Pain, Objective Assessment of Sedation
Infrared Pupillometry During General Anesthesia to Predict Pain
The study comprises of a series of pupillary measurements using infrared pupillometry in patients undergoing arthroscopic knee surgery of any type.
- Trial name
- NCT02058511
- Testing
- Anesthesia Premedication, Induction and Maintenance, Pupillometry after administration of anesthetic drugs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, San Francisco
Pain, Postoperative
Post-operative Patient Positioning Device for Improvement of Post-Operative Pain
This paucity of evidence supporting or dissuading the use of postoperative abdominal support following cesarean section for the reduction of postoperative pain leaves important clinical questions unanswered.
- Trial name
- NCT04797637
- Testing
- ABBy® Adjustable Panniculus Retractor for Wound Care
- Where
- United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pelvic Organ Prolapse, Abdominal Surgery
The Effect of Abdominal Binder Use on Postoperative Pain and Mobility in Patients Undergoing Pelvic Surgery
To determine the effect of post-operative abdominal binder usage on total narcotic usage after undergoing surgery. To determine if abdominal binder usage results in decreased visual analog scale (VAS) pain scores and shorter time…
- Conditions
- Pelvic Organ Prolapse, Abdominal Surgery, Laparoscopic Surgery, Post Operative Pain
- Trial name
- NCT03684304
- Testing
- Abdominal binder
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Wound Infection Due to Staphylococcus Aureus, MRSA Infection of Postoperative Wound
S. Aureus Screening and Decolonization
Staphylococcus aureus (SA) healthcare-associated infections (HAI) cause significant morbidity and mortality. SA causes 15% of all HAI and 30% of surgical site infections (SSIs).
- Trial name
- NCT02182115
- Testing
- antiseptic bundle, standard of care
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Arthroplasty, Replacement, Knee, Pain, Postoperative
Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) can be associated with a large amount of postoperative pain. This pain can oftentimes be severe enough to limit participation in physical therapy and ultimately delay discharge resulting in increased…
- Trial name
- NCT02453360
- Testing
- Adductor Canal Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Wisconsin, Madison
Postoperative Complications
Risk Factors Predicting Serious Complications With Laparoscopic Gastric Bypass Surgery
The rate of serious complications are relatively low in bariatric surgery today, but still 3-4 % will suffer from a serious complication.
- Trial name
- NCT01862159
- Testing
- laparoscopic gastric bypass surgery
- Where
- Sweden
- Volunteers
- 25,038 people
- Sponsor
- Region Örebro County
Postoperative Wound Haemorrhage
Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery
Bleeding after Mohs micrographic surgery for skin cancer is a low risk complication that can occur. This study aims to determine the effect of a drug, often used to reduce bleeding, called tranexamic acid when applied topically…
- Trial name
- NCT04541303
- Testing
- Tranexamic acid, normal saline
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Missouri-Columbia
Infertility, Female, Pain, Postoperative
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
In this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge…
- Trial name
- NCT03073980
- Testing
- IV Acetaminophen, PO Acetaminophen
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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