Clinical trials: Post-operative Dental Pain
Postoperative Pain
Remifentanil and Fentanyl in Dental Surgery (REFEDS)
This study was a prospective comparative study. The purpose of this study was to investigate the hypothesis whether remifentanil compared to fentanyl can induce less inflammatory and stress response to the day-case dental surgery…
- Trial name
- REFEDS (NCT02619032)
- Testing
- Remifentanil, Fentanyl
- Where
- Greece
- Volunteers
- 46 people
- Sponsor
- Attikon Hospital
Endodontically Treated Teeth
The Effect of Root-canal Medicaments on Post-operative Pain in Re-treatment Cases
This randomized clinical trial compares the effects of intracanal medicaments on the incidence of postoperative pain and flare-up in asymptomatic retreatment cases.
- Trial name
- NCT05052814
- Testing
- root canal medicament-calcium hydroxide, root canal medicament-chlorhexidine gel, root canal medicament-calcuim hyroxide &chlorhexidine ge
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Pain
An Effectiveness and Safety Study of Acetaminophen 1000 mg and Ibuprofen 400 mg in Postoperative Dental Pain
The purpose of this study is to determine the onset of pain relief from a single dose of acetaminophen and ibuprofen in subjects experiencing postoperative dental pain following the surgical extraction of at least three molars.
- Trial name
- NCT00240864
- Testing
- acetaminophen, ibuprofen
- Volunteers
- 224 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Pulp Necrosis, Apical Periodontitis
PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth
This clinical trial will compare platelet-rich plasma (PRP)-assisted regenerative endodontic treatment with conventional root canal treatment in mature permanent teeth with pulp necrosis and apical periodontitis.
- Trial name
- NCT07918664
- Testing
- PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- TC Erciyes University
Post-operative Pain
Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study
The objective is to assess the efficacy and tolerability of a combination of 400 mg ibuprofen plus 1000 mg acetaminophen, 200 mg ibuprofen plus 500 mg acetaminophen compared with Nurofen Plus® and Panadeine® Extra.
- Trial name
- NCT01229449
- Testing
- Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus®
- Where
- United States
- Volunteers
- 678 people
- Sponsor
- Reckitt Benckiser LLC
Postoperative Nausea and Vomiting, Post Operative Pain
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children
this study will aim to evaluate the effects of dexmedetomidine, dexamethasone and Ondansetron on the prevention of postoperative nausea and vomiting in children undergoing dental rehabilitation surgery.
- Conditions
- Postoperative Nausea and Vomiting, Post Operative Pain, Emergence Delirium
- Trial name
- NCT05124067
- Testing
- Dexamethasone, Ondansetron, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pain
Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone.
Root canal procedure is a common procedure in dentistry. Acute inflammatory response in peri-radicular tissues after root canal treatment is the main cause of post op pain.
- Trial name
- NCT06432712
- Testing
- Dexamethasone 4mg
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shoaib Rahim
Necrotic Pulp
Effect of Etidronate in Sodium Hypochlorite Versus Sodium Hypochlorite on the Intensity of Postoperative Pain
To compare the effect of using Etidronate in sodium hypochlorite versus sodium hypochlorite irrigating solution on: Postoperative pain in patients with necrotic pulp.
- Trial name
- NCT04035330
- Testing
- etidronate in sodium hypochlorite, sodium hypochlorite
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Dental Pain
A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo
Researchers are looking for a better way to relieve pain in people, such as after dental surgery. Participants in this study, have had 3 or 4 third molars (cheek teeth) removed and subsequently have moderate to severe tooth pain.
- Trial name
- NCT05485805
- Testing
- Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Pulp Necrosis, Postoperative Pain
Evaluation of Post-operative Pain and Bacterial Load Reduction After Application of Three Intra-canal Medications (Cocoa Husk Versus Calcium Hydroxide With and Without Cocoa) in Necrotic Mandibular First Molar.
The study will aim to evaluate the postoperative pain and bacterial load after application of two intracanal medications in mandibular first molar teeth with necrotic pulp.
- Trial name
- NCT07790796
- Testing
- Root canal treatment with intracanal medication by calcium hydroxide for one week., Root canal treatment with intracanal medication by cocoa husk for one week, Root canal treatment with intracanal medication by calcium hydroxide with cocoa husk for one week.
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Pulp Necrosis
Comparison Between Reciproc and Protaper Next
Comparing the postoperative pain resulting after mechanical instrumentation using Reciproc reciprocating files versus that resulting after using ProTaper Next rotary files in asymptomatic necrotic molars.
- Trial name
- NCT02946099
- Testing
- Reciproc files in reciprocating motion, ProTaper Next files in continuous rotary motion
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postoperative Dental Pain
Efficacy Of PF-05089771 In Treating Postoperative Dental Pain
The objective of this study is to evaluate the overall pain relief of a single dose of PF-05089771 against placebo following third molar extraction.
- Trial name
- NCT01529346
- Testing
- PF-05089771, Ibuprofen
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- Pfizer
Endodontically Treated Teeth, Post Operative Pain
Bioceramics Pain Control
Postoperative pain in endodontic retreatment cases presents a challenge to any endodontist. Tricalcium silicate materials as mineral trioxide aggregate (MTA) and bioceramics have shown favorable periapical tissue reactions and…
- Trial name
- NCT05399303
- Testing
- obturation
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Misr International University
Pain, Postoperative, Quality of Life
Efficacy of Two Local Anesthetics on Quality of Life After Endodontic Treatment
In this randomized controlled double-blinded study, subjects will be assigned to one of two study groups to either be anesthetized with Bupivacaine or Lidocaine prior to needed treatment of pulpectomy/endodontic debridement on a…
- Trial name
- B-OHIP14 (NCT04787731)
- Testing
- Bupivacaine Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Apical Periodontitis, Dental Pulp Necrosis
Postoperative Pain and PTN and Reciproc
In this clinical trial, the researchers will investigate the effect of single-file reciprocating file system (Reciproc) versus multi-file rotational file systems (ProTaper Next) on the postoperative pain in adult patients who…
- Trial name
- NCT03380585
- Testing
- Reciprocating single-file system, Rotational multi-file system.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Apical Periodontitis, Postoperative Pain
Effectiveness of Different Obturation Techniques
Aim: Evaluation of the effect of different obturation techniques on postoperative pain level and radiographic healing on non-surgical endodontic retreatment (NSER) applied in a single visit in teeth with single root canal and…
- Conditions
- Apical Periodontitis, Postoperative Pain, Endodontically Treated Teeth
- Trial name
- NCT06226740
- Testing
- Single Visit Non Surgical Root Canal Treatment Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Pain, Postoperative
Safety and Efficacy of Intranasal Ketamine for the Treatment of Postoperative Dental Pain
Once patients' postoperative pain intensity reaches a moderate-to-severe level, they are randomized to receive intranasal ketamine or placebo.
- Trial name
- NCT00488787
- Testing
- intranasal ketamine
- Volunteers
- 40 people
- Sponsor
- Javelin Pharmaceuticals
Dental Pain
Methodological Validation of Ibuprofen Verses Placebo for Post Operative Pain After Third Molar Extraction Surgery
This is a single center placebo controlled, prospective, randomized study on healthy adults undergoing third molar surgery.
- Trial name
- NCT02096926
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lotus Clinical Research, LLC
Dental Pain, Endodontically Treated Teeth
XP-Endo Finisher on Postoperative Pain in Retreatment Cases Using Mtwo R Files
Introduction: Postoperative pain is one of the most critical issues in our daily practice. , postoperative pain control is essential for patient satisfaction and comfort.
- Trial name
- NCT06625853
- Testing
- Mtwo R files with Xp-Endo finisher file, Mtwo R files
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Hams Hamed Abdelrahman
Endodontic Disease
Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment of Single Rooted Teeth
This study aims to compare the postoperative pain and incidence of extrusion of two intracanal medications in the retreatment of single-rooted teeth.
- Trial name
- NCT06913673
- Testing
- Bio-c Temp, Metapex
- Volunteers
- 30 people
- Sponsor
- Minia University