Clinical trials: Post-operative Pain Control
Pain
Exparel Interscalene vs Indwelling Catheter
The investigators are comparing an indwelling catheter with intermediate duration local anesthetic to a single shot peripheral nerve block with long acting a local anesthetic (Exparel).
- Trial name
- NCT03827213
- Testing
- Exparel, Indwelling Interscalene Catheter
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Montefiore Medical Center
Laparotomy, Hepatic Resection
Continuous Preperitoneal Infusion of Ropivacaine After Open Liver Resection: Effect on Post-operative Recovery and Morbidity.
Intravenous morphine Patient-Controlled analgesia is gold standard on post - operative liver resection. But, opioids tend to be ineffective for pain that is associated with movement and have significant short-term side effects…
- Trial name
- ROPIHEP (NCT01890408)
- Testing
- wound infusion ropivacaine
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain
Pain Control and Recovery After Thoracic Surgery Using SPSIP Block
Thoracic surgery is frequently associated with significant postoperative pain, which may impair respiratory function, mobilization, recovery, and patient satisfaction.
- Trial name
- NCT07850388
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Osteo Arthritis Knee, Pain, Postoperative
Extended Oral Tranexamic Acid After Total Knee Arthroplasty
The utilization of intraoperative tranexamic acid (TXA), whether administered intravenously or orally, has become a standard practice in total joint arthroplasty (TJA).
- Trial name
- NCT06618820
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Campbell Clinic
Total Knee Replacement, Post-operative Pain
Tapentadol vs Tramadol in Total Knee Arthroplasty
Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Total Knee Replacement (TKR).
- Conditions
- Total Knee Replacement, Post-operative Pain, Chronic Pain
- Trial name
- NCT06269770
- Testing
- Tapentadol, Tramadol
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Thessaly
Cesarean Delivery, Postpartum Comfort
Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks.
- Conditions
- Cesarean Delivery, Postpartum Comfort, Postpartum Pain, Post-operative Pain
- Trial name
- PACESS (NCT07102641)
- Testing
- Acetaminophen, NSAID (Ketorolac/Ibuprofen)
- Where
- United States
- Volunteers
- 825 people
- Sponsor
- Thomas Jefferson University
Post Operative Pain, Recurrence
Video-assisted Anal Fistula Treatment Versus Seton in the Management of High Peri Anal Fistula
Anal fistula is the most common Peri anal disease. It's a disease with an incidence of 9 in 100,000. Anal fistula is classified on the basis of its location into high and low anal fistula, above or below dentate line…
- Trial name
- NCT02313597
- Testing
- SETON, VAAFT
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Dr. SamiUllah
Postoperative Pain
Peritoneal Nebulization of Ropivacaine for Pain Control After Laparoscopic Colectomy
The purpose of this study is to assess if intraperitoneal nebulization of Ropivacaine 150 mg produces better postoperative pain control than Saline nebulization after laparoscopic colectomy.
- Trial name
- NCT01432496
- Testing
- Ropivacaine 150 mg, saline 15 ml
- Where
- 3 sites in Italy
- Volunteers
- 130 people
- Sponsor
- San Gerardo Hospital
Neuropathic Pain, Chronic Pain
Post-operative Thoracic Epidural Analgesia and Incidence of Major Complications: a Large Retrospective Dual Center Experi-ence
A retrospective observational dual center study investigating side effects and major complications after thoracic epidural insertion according to local safety protocols.
- Conditions
- Neuropathic Pain, Chronic Pain, Thoracic Cancer
- Trial name
- NCT05909007
- Testing
- thoracic epidural insertion
- Where
- Greece
- Volunteers
- 1,145 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Hip Arthroplasty, Total, Postoperative Pain
Pericapsular Nerve Group Block Versus Intrathecal Morphine for Pain After Hip Surgery
Pain after hip replacement surgery is often severe and is commonly treated with opioids, which may cause nausea, vomiting, sedation, difficulty passing urine and slow breathing.
- Conditions
- Hip Arthroplasty, Total, Postoperative Pain, Hip Arthroplasty, Analgesia
- Trial name
- NCT07784192
- Testing
- Morpine, Ultrasound-guided pericapsular nerve group block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Selcuk University
Postoperative Pain
Different Concentrations of Bupivacaine in Erector Spinae Plane Block in Hip Surgeries
The prevalence of hip replacement surgery is increasing nowadays. Patients are usually older age and suffer from comorbidities may be an anesthetic and analgesic challenge.
- Trial name
- NCT04442750
- Testing
- Erector spinae plane block Technique, General anesthesia, Bupivacaine 0.5%
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Pain, Postoperative
The OBstetric Lidocaine Patch (OBLido) Trial
This study will be a single-center, single blind, randomized controlled trial. The study will be conducted at UnityPoint-Health Meriter Hospital under investigators from the University of Wisconsin-Madison.
- Trial name
- OBLido (NCT03810235)
- Testing
- Transdermal Lidocaine Patch
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Amputation, Neuroma Amputation
Effect of Prophylactic TMR and RPNI on Neuroma and Phantom Limb Pain
The purpose of this study is to analyze the efficacy of novel interventions in post-amputation surgical care (specifically Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interface) on post-amputation pain and…
- Conditions
- Amputation, Neuroma Amputation, Phantom Limb Pain, Residual Limbs
- Trial name
- NCT05344261
- Testing
- Targeted Muscle Re-innervation, Regenerative Peripheral Nerve Interface, Standard Post-Amputation Surgical Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Post Operative Pain, Preemptive Analgesia
Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries
Postoperative pain is an important problem, especially for day case surgeries. It has negative effects on patient's hemodynamics and can cause delayed ambulation resulting in prolonged duration of hospital stay and poor patient…
- Trial name
- NCT05990686
- Testing
- tramadol plus paracetamol, Fentanyl Injection
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Post Operative Pain, Postoperative Hemorrhage
Efficacy of Local Infiltration of Tranexamic Acid and Lidocaine in Tonsillar Bed on Postoperative Bleeding and Pain During Tonsillectomy Surgery: Prospective, Randomized, Control Study
All anesthetic techniques aim to lessen intra-operative surgical site bleeding because it is a major problem and does not help with precision, surgery time, or postoperative wound healing.
- Trial name
- NCT05817474
- Testing
- lidocaine (2 %) 2 ml and tranexamic acid
- Where
- Egypt
- Volunteers
- 94 people
- Sponsor
- mohamed
Bunion
A Study to Evaluate Analgesic Efficacy and Safety of PRF-110 for Post-surgical Pain
PRF-110 is a viscous, yellowish clear oily solution of ropivacaine intended for administration into surgical sites to provide post-operative analgesia.
- Trial name
- NCT05773846
- Testing
- Ropivacaine
- Where
- 7 sites in United States
- Volunteers
- 428 people
- Sponsor
- PainReform LTD
Post Operative Pain
Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
Patients undergoing breast cancer surgery experience persistent pain after surgery and subsequent development of chronic pain. Parecoxib or paracetamol has been reported to reduce postoperative pain in mastectomy.
- Trial name
- NCT05757388
- Testing
- Parecoxib + paracetamol, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Thyroid Diseases, Wound Healing
Safety and Efficacy of NTP in Thyroid Surgery: Pilot Study on Morbidity Prevention and Adjuvant Oncological Control
The goal of this clinical trial is to evaluate the therapeutic efficacy and safety of non-thermal plasma (NTP) as an adjuvant treatment for surgical bed decontamination and accelerated tissue repair in patients undergoing total…
- Conditions
- Thyroid Diseases, Wound Healing, Thyroidectomy, Surgical Wound Infection
- Trial name
- NCT07382973
- Testing
- Atmospheric Pressure Non-Thermal Plasma, Standard Surgical Wound Care Protocol
- Where
- Mexico
- Volunteers
- 26 people
- Sponsor
- National Institute of Nuclear Research - Mexico
Pain, Postoperative, Irreversible Pulpitis
Can Instrumentation Kinematics Affect Post Operative Pain and Substance P Levels? A Randomized Controlled Trial
The aim of this study was to evaluate the effect of continuous rotation and reciprocation kinematics on post operative pain and difference in substance P levels in patients with irreversible pulpitis with symptomatic apical…
- Conditions
- Pain, Postoperative, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT06081335
- Testing
- EdgeEndo x7 continuous rotation files, EdgeOne Fire reciprocating files
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion
This study will describe postoperative pain management for spine surgery patients receiving liposomal bupivacaine (Exparel®) compared to patients not receiving the drug.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
- Trial name
- NCT03745040
- Testing
- Liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Allina Health System
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