Clinical trials: Post-operative Pain Management
Post Operative Pain, Preemptive Analgesia
Paracetamol Plus Tramadol Versus Fentanyl in Day Case Surgeries
Postoperative pain is an important problem, especially for day case surgeries. It has negative effects on patient's hemodynamics and can cause delayed ambulation resulting in prolonged duration of hospital stay and poor patient…
- Trial name
- NCT05990686
- Testing
- tramadol plus paracetamol, Fentanyl Injection
- Where
- Egypt
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Bunion
A Study to Evaluate Analgesic Efficacy and Safety of PRF-110 for Post-surgical Pain
PRF-110 is a viscous, yellowish clear oily solution of ropivacaine intended for administration into surgical sites to provide post-operative analgesia.
- Trial name
- NCT05773846
- Testing
- Ropivacaine
- Where
- 7 sites in United States
- Volunteers
- 428 people
- Sponsor
- PainReform LTD
Analgesia, Arthropathy of Knee
Comparison of Two Different Regional Analgesia Techniques for Patients Undergoing Total Knee Arthroplasty
The objective of this clinical trial is to compare two regional analgesia techniques in patients undergoing total knee arthroplasty: IPACK (Infiltration of local anesthetic between the Popliteal Artery and Capsule of the Knee) vs…
- Conditions
- Analgesia, Arthropathy of Knee, Postoperative Pain
- Trial name
- PIPACK (NCT06179641)
- Testing
- Selective tibial nerve block, IPACK block
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Postoperative Pain, Psychological Factors
Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery
This study investigates the relationship between psychosocial factors, particularly self-esteem and personality traits, and postoperative pain in patients undergoing aesthetic breast surgery.
- Conditions
- Postoperative Pain, Psychological Factors, Breast Surgery, Aesthetic Surgery
- Trial name
- NCT06707818
- Testing
- Preoperative Interventions, Intraoperative Interventions, Postoperative Interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- V.K.V. American Hospital, Istanbul
Hip Fractures, Hip Injuries
Iliopsoas Plane Block vs PENG Block for Hip Arthroplasty
Hip arthroplasty is one of the most common orthopedic procedures especially in elderly patients due to deformation of joints. Patients may complain of severe pain due to surgical trauma and prosthesis.
- Conditions
- Hip Fractures, Hip Injuries, Hip Arthropathy
- Trial name
- NCT05397145
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Medipol University
Lung Cancer (Diagnosis), Pain Management
Impact of Perioperative Body Temperature on Postoperative Complications and Pain in Video-assisted Thoracoscopic Surgery Patients Utilizing Continuous Temperature Monitoring
A report from the National Cancer Center (published in JNCC) shows that lung cancer has the highest rates of both new cases and deaths in China.
- Conditions
- Lung Cancer (Diagnosis), Pain Management, Postoperative Complications, Body Temperature Measurement
- Trial name
- NCT07251439
- Testing
- Continuous body temperature monitoring
- Volunteers
- 144 people
- Sponsor
- Peking University People's Hospital
Cystectomy
Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy
The purpose of this study is to compare the difference between four different pain control methods in patients who will be having a cystectomy surgery (surgical removal of the bladder).
- Trial name
- NCT04300231
- Testing
- epidural bupivacaine 0.05%, Liposomal bupivacaine, bupivacaine 0.125%
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
Acute Post Operative Pain, Laparotomy
PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose
Pain control after surgery is a crucial component of postoperative recovery. Thus, in open abdominal surgery, the use of TEA (Thoracic epidural analgesia) has become a gold standard.
- Conditions
- Acute Post Operative Pain, Laparotomy, Epidural Analgesia
- Trial name
- PIBDOSE (NCT05534945)
- Testing
- Programmed intermittent epidural bolus 5 ml, Programmed intermittent epidural bolus 6 ml, Programmed intermittent epidural bolus 7 ml
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Opoid Managment, Pain Management
Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Elderly Patients Undergoing Spine Surgery
The goal of this clinical trial is to learn if an anesthesia management strategy called opioid-sparing anesthesia could help reduce postoperative opioid consumption, pain intensity and enhance recovery in elderly patients…
- Trial name
- NCT07588802
- Testing
- Opioid-Sparing Protocol, Routine anesthesia protocol
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Postoperative Pain
Efficacy and Safety of Q8003 in the Management of Post-bunionectomy Pain
This study will explore the efficacy and safety of a fixed dose combination of morphine and oxycodone for management of acute postoperative pain.
- Trial name
- NCT00560183
- Testing
- Q8003 (morphine sulfate and oxycodone hydrochloride)
- Where
- 6 sites in United States
- Volunteers
- 256 people
- Sponsor
- QRxPharma Inc.
Pain, Postoperative
Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants
The objective of this study is to evaluate the safety and clinical utility of the active, SSEC fentanyl 40 micrograms (mcg) for the management of acute, postoperative pain in pediatric participants.
- Trial name
- NCT02395653
- Testing
- fentanyl
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- The Medicines Company
Pain, Postoperative
A Comparison of the Safety and Effectiveness of Two Forms of Patient-controlled Pain Medication Used After Scheduled Abdominal or Pelvic Surgery: The Fentanyl Transdermal System Versus the Morphine Intravenous Pump
The purpose of this study is to compare two pain medications delivered by two different forms of patient-controlled pain management systems: the Fentanyl HCl Patient-Controlled Transdermal System (E-TRANS fentanyl) and the…
- Trial name
- NCT00266539
- Testing
- E-TRANS Fentanyl hydrochloride; Morphine
- Volunteers
- 506 people
- Sponsor
- Alza Corporation, DE, USA
Inguinal Hernia, Postoperative Pain
Preoperative Etanercept Before Inguinal Hernia Surgery
Inguinal hernia repair is one of the most frequently performed operations in young men. Persistent pain after inguinal surgery represents a significant cause of disability, occurring in between 15%-35% of cases.
- Trial name
- NCT00825344
- Testing
- Etanercept, Saline
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Oral Cancer, Postoperative Pain Management
Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.
Background: Oral cancer radical surgery often requires free flap reconstruction. Postoperative pain is severe, and traditional opioids like sufentanil have side effects and may adversely affect tumor biology.
- Conditions
- Oral Cancer, Postoperative Pain Management, Free Tissue Flaps, Mouth Neoplasms
- Trial name
- NCT07401641
- Testing
- Dezocine and Sufentanil combination, Nalbuphine and Sufentanil combination
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Analgesia, Surgery
High Versus Low Dose Serratus Anterior Plane Block After Minimally Invasive Valve Surgery.
This study aims to compare the efficacy and quality of pain relief provided by the high-dose serratus anterior plane (SAP) block with the standard SAP block in preventing and treating acute postoperative pain after total…
- Conditions
- Analgesia, Surgery, Cardiac Disease, Post Operative Pain
- Trial name
- NCT06205875
- Testing
- High dose serratus anterior plane block (2.4 mg/kg patient ideal body weight), Low dose serratus anterior plane block (1.2mg/kg patient ideal body weight), PCIA with morphine
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Jessa Hospital
Post-operative Pain Control
Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone
Photorefractive keratectomy (PRK) is a refractive error correction procedure that helps eliminate or reduce the dependence on corrective lenses. An important aspect of PRK is post-operative pain management.
- Trial name
- NCT04399122
- Testing
- acetaminophen/codeine vs acetaminophen/oxycodone
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Pain After Shoulder Surgery, Shoulder Arthroscopic Surgery
Comparison of SPSIPB With SSB and ICB Combination in Arthroscopic Shoulder Surgeries
The aim to compare postoperative analgesic requirements between patients undergoing arthroscopic shoulder surgery who received either the SSB-ICB combination or SPSIPB, and to determine whether one technique has superiority over…
- Trial name
- NCT07233681
- Testing
- suprascapular nerve block, Serratus posterior superior intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cumhuriyet University
Postoperative Pain.
The Effects of Peri-operative Pregabalin Administration on Post-operative Analgesia in Patients Undergoing Coronary Bypass Grafting
We hypothesize that the perioperative administration of pregabalin will significantly decrease pain scores and post-operative opioid requirements for patients undergoing coronary artery bypass grafting, and reduces the incidence…
- Trial name
- NCT00623285
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Arthroplasty, Replacement, Knee, Pain, Postoperative
Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study
The objective of this study is to see how pain management and its outcomes are effected when pharmacogenomic testing is used to determine patient specific pain medication and dosing.
- Trial name
- NCT02711592
- Testing
- Genetic Panel for Analgesics
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- TriHealth Inc.
Hemorrhoids, Postoperative Pain
Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy
The goal of this clinical trial is to evaluate whether oral nifedipine reduces postoperative pain and improves wound healing after hemorrhoidectomy in adult patients aged 18-65 years undergoing elective surgery for grade III or…
- Conditions
- Hemorrhoids, Postoperative Pain, Wound Healing, Analgesia
- Trial name
- NIFEDIPINE-HD (NCT07659665)
- Testing
- Nifedipine 20 Mg
- Where
- Yemen
- Volunteers
- 100 people
- Sponsor
- Sana'a University
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