Clinical trials: Post-operative Pain Management
Pain, Postoperative
The Effect of Femoral Nerve Block on Postoperative Opioid Use After Anterior Cruciate Ligament (ACL) Reconstruction
This study evaluates the effect of a femoral nerve block on opioid requirements following anterior cruciate ligament (ACL) reconstruction. This is a double blind, prospective randomized controlled trial.
- Trial name
- NCT00175630
- Testing
- Administration of a femoral nerve block (bupivacaine HCL)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Post Operative Pain
Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Appendectomy Surgeries
The goal of this study is to compare the analgesic efficacy of M-TAPA block and TAP block in patients undergoing laparoscopic appendectomy surgeries
- Trial name
- NCT06483581
- Testing
- M-TAPA block with bupivacaine 25%, TAP block with bupivacaine 25%
- Volunteers
- 30 people
- Sponsor
- Cumhuriyet University
Breast Cancer
Pecs II Block and PaB Could be an Alternative in Breast Surgery
The association between ultrasound-guided Pecs II block and parasternal block can represent a valid alternative in the management of acute and postoperative pain syndrome after quadrantectomy with or without axillary dissection.
- Trial name
- NCT02865265
- Testing
- Pecs II and parasternal blocks
- Volunteers
- 180 people
- Sponsor
- Emiliano Petrucci
Pain, Postoperative, Analgesics, Opioid
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
A blinded randomized control trial in living kidney donors. The study group will receive a liposomal bupivacaine Trans Quadratus Lumborum (TQL) block after the induction of general anesthesia.
- Conditions
- Pain, Postoperative, Analgesics, Opioid, Analgesics, Non-Narcotic, Physiological Effects of Drugs
- Trial name
- NCT03294109
- Testing
- Abdominal wall block with liposomal bupivicaine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Regional Anaesthesia
QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery
Local and/or regional analgesia techniques are critical components of an optimal multimodal analgesia technique, as they have been shown to improve pain relief as well as reduce opioid requirements.
- Trial name
- NCT06688136
- Testing
- ropivacaine
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Huazhong University of Science and Technology
Post-operative Pain Management
Are Superficial Parasternal Intercostal Plane (SPIP) Blocks With Bupivacaine and With or Without Adjuvants Helpful for Post-operative Pain After Coronary Artery Bypass Grafting?
The purpose of this study is to determine whether the addition of the superficial parasternal intercostal plane (SPIP) block alone (30cc of 0.25% bupivacaine) or plus Magnesium (200mg of magnesium sulfate) or plus Magnesium +…
- Trial name
- NCT05003765
- Testing
- Bupivacaine 0.25% Injectable Solution, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 200 mg, Buprenorphine 300 mcg
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wayne State University
Pain Management
Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain
Bupivacaine is the most widely used local anesthetic agent across majority of the Cardiac Implantable Electronic device (CIED) implant procedures in the United States.
- Trial name
- NCT05575999
- Testing
- Bupivacaine alone OR Bupivacaine-Ketorolac-Ketamine (BKK) Combination
- Where
- 3 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Pain, Post-operative
Evaluation of N1539 Following Major Surgery
The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.
- Trial name
- NCT02720692
- Testing
- N1539
- Where
- 32 sites in United States, Australia and 2 more
- Volunteers
- 722 people
- Sponsor
- Baudax Bio
Lung Transplantation, Pain Management
The Effect of Bupivacaine Liposomes on Postoperative Pain in Lung Transplant Patients After Intercostal Nerve Block: a Randomized Controlled Study
The goal of this clinical trial is to evaluate the efficacy and safety of liposomal bupivacaine for postoperative analgesia in adult patients undergoing lung transplantation.
- Conditions
- Lung Transplantation, Pain Management, Liposomal Bupivacaine
- Trial name
- NCT07641647
- Testing
- LB/BH intercostal nerve block, BH intercostal nerve block
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
FISTULA IN ANO
Comparison Between Laser and Open Fistula Surgeries in the Management of Fistula - In - Ano
This prospective randomized controlled trial compared the outcomes of laser versus open surgical techniques in the management of fistula-in-ano among 100 patients at a tertiary care center.
- Trial name
- NCT07083778
- Testing
- Laser Fistula Surgery (FiLaC - Fistula-tract Laser Closure), Open Fistula Surgery (Fistulotomy, Fistulectomy, or LIFT Procedure)
- Where
- India
- Volunteers
- 100 people
- Sponsor
- GSVM Medical College
Efficacy of Drugs in Pain Management
Dexamethasone Versus Dexmedetomidine in IPACK Block to Reduce Pain Post Arthroscopic Knee Surgeries
The investigators will test the effects of dexamethasone versus dexmedetomidine as adjuvant to bupivacaine in IPACK Block and it's direct effect in decreasing pain post operative following Arthroscopic knee surgeries
- Trial name
- NCT07024043
- Testing
- Dexamethasone versus Dexmedetomidine in IPACK Block to reduce pain post Arthroscopic knee surgeries, IPACK and multi-modal analgesic regimen
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Liposomal Bupivacaine
Exparel Versus Bupivacaine in Post-operative Pain Control
This is a prospective, randomized study to evaluate anaesthetic parameters, postoperative analgesia and oral analgesic consumption comparing exparel (liposomal bupivacaine) vs. standard bupivacaine
- Trial name
- NCT06547255
- Testing
- Bupivacaine liposome injectable suspension
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Postoperative Pain Management, Video-assisted Thoracoscopic Surgery (VATS)
Analgesic Effectiveness of SPSIPB Versus Thoracic Epidural and Systemic Opioid Analgesia After VATS (SPSIPB-VATS)
This prospective observational study aims to compare the postoperative analgesic effectiveness of three commonly used pain management strategies in video-assisted thoracoscopic surgery (VATS): Serratus Posterior Superior…
- Conditions
- Postoperative Pain Management, Video-assisted Thoracoscopic Surgery (VATS), Thoracic Epidural Analgesia, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- SPSIPB-VATS (NCT07238348)
- Volunteers
- 120 people
- Sponsor
- Karadeniz Technical University
Postsurgical Pain Management
A Trial of HR021618 in Postsurgical Pain Management
The study is being conducted to evaluate the efficacy, safety of HR021618 and to explore the reasonable dosage of HR021618 for Pain Management after Orthopaedic surgery.
- Trial name
- NCT04699175
- Testing
- HR021618
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Post Operative Pain, Acute
Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord.
- Trial name
- NCT05150795
- Testing
- Pregabalin 150mg, Fentanyl 100 micrograms ampoule
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Pain Management, Postoperative Acute Pain
Effect of Sedation After Ultrasound-Guided Spinal Anesthesia on Back Pain
This study will evaluate whether giving sedation before spinal anesthesia, when performed with ultrasound guidance, reduces the risk of developing back pain after surgery.
- Conditions
- Pain Management, Postoperative Acute Pain, Chronic Back Pain
- Trial name
- NCT07198412
- Testing
- Ultrasound-guided spinal anesthesia, Midazolam plus ultrasound-guided spinal anesthesia, Landmark-guided spinal anesthesia
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Benha University
Post Operative Analgesia, Rebound Pain
Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A
Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral…
- Conditions
- Post Operative Analgesia, Rebound Pain, Post Operative Pain, Acute
- Trial name
- REBOUND (NCT07666971)
- Testing
- Morphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lumbar Disc Herniation, Pain, Postoperative
mTLIP vs. ITP Blocks in Lumbar Disc Surgery
to compare ultrasonography (USG)-guided intertransverse process block and modified thoracolumbar interfascial plan (mTLIP) block in the treatment of postoperative pain in patients undergoing lumbar disc herniation surgery under…
- Conditions
- Lumbar Disc Herniation, Pain, Postoperative, Regional Aneshesia
- Trial name
- NCT06391541
- Testing
- modified thoracolumbar interfacial plan block (mTLIP), Intertransverse process block (ITP)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07520097)
- Testing
- Concentrated Growth Factor (CGF) Gel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.