Clinical trials: Post-operative Sensitivity, open to volunteers
Postoperative Cough, Cough Hypersensitivity Syndrome
Effects of Energy Versus Mechanical Surgical Devices on Postoperative Cough
Numerous current studies have indicated that transecting the pulmonary plexus nerve as a routine step in radical lung cancer surgery is an independent risk factor for cough hypersensitivity (CH).
- Trial name
- ENERGY-COUGH (NCT07524712)
- Testing
- Energy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Tongji Hospital
Coronary Artery Disease, Noncardiac Surgery
Preoperative vs Postoperative Revascularization in Coronary Heart Disease Patients Undergoing Time-Sensitive Non-Cardiac Surgery (CHRONOS-PCI)
To compare the safety and efficacy of preoperative versus postoperative revascularization strategies in patients with coronary heart disease undergoing time-sensitive non-cardiac surgery.
- Trial name
- CHRONOS-PCI (NCT07175870)
- Testing
- Non-cardiac surgery followed by postoperative PCI, Preoperative PCI followed by delayed non-cardiac surgery ~3 months later
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Dentin Caries
Evaluation of the Effect of Flowable Composites on Postoperative Sensitivity in Class I Restorations.
The aim of this study is to evaluate the effect of flowable conventional and bulk-fill composites on postoperative sensitivity in class I cavities over long-term follow-up.
- Trial name
- NCT07343050
- Testing
- Dental restorations
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Postoperative Pain
Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment.
- Trial name
- NCT06937853
- Testing
- Ibuprofen 600 mg, diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Digestive System Surgical Procedures
Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery
The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of…
- Trial name
- POLYAMAL (NCT04219956)
- Testing
- Polyamine Deficient Diet
- Where
- 4 sites in France
- Volunteers
- 278 people
- Sponsor
- Nantes University Hospital
Perioperative/Postoperative Complications, Anaphylaxis
Diagnosis and Allergen Identification of Perioperative Anaphylaxis
Perioperative anaphylaxis may lead to fatal respiratory and/or circulatory events, yet both clinical diagnosis and management are challenging.
- Conditions
- Perioperative/Postoperative Complications, Anaphylaxis, Tryptase, Allergens
- Trial name
- NCT06793163
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Peking University First Hospital
Excess Skin of Both Eyelids, Contrast Sensitivity
The Effect of Upper Blepharoplasty on Vision Quality in the Early Postoperative Period
Contrast sensitivity (CS) and tear film (TF) changes are noted in late postoperative period after upper blepharoplasty (UB), while the same was rarely investigated in the early postoperative period.
- Conditions
- Excess Skin of Both Eyelids, Contrast Sensitivity, Tear Film Insufficiency of Both Eyes, Corneal Topography
- Trial name
- NCT05549713
- Testing
- Upper blepharoplasty
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- Osijek University Hospital
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Lung Carcinoma
Predictive Value of CEA and ctDNA in Lung Cancer Recurrence
The study aims to investigate the predictive value of CEA levels for postoperative recurrence in the highly sensitive CEA lung cancer patients and to explore whether the dynamic changes of postoperative CEA and MRD in this…
- Trial name
- NCT07170046
- Volunteers
- 100 people
- Sponsor
- Guangdong Provincial People's Hospital
Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine
Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)
This pilot study investigates the effects of reducing pain medication including opioids and anticonvulsants, on spinal cord sensitivity during closed-loop spinal cord stimulation (SCS).
- Conditions
- Failed Back Surgery Syndrome (FBSS), Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Neurophysiological Sensitivity to Spinal Cord Stimulation
- Trial name
- ECAP-MED Pilot (NCT07502612)
- Testing
- Spinal Cord Stimulation with Evoke Closed-Loop System
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Brai²n
Post-Operative Hypersensitivity
Effects of Rebonding Technique and Final Cure in Post-operative Hypersensitivity in Class 1 Composite Restorations
Rebonding technique has been suggested to address the issue of post-operative hypersensitivity in composite restorations. it involves the application of bonding agent on composite restoration following finishing and polishing.
- Trial name
- NCT07041424
- Testing
- treatment group 1: total etch bonding agent used with rebonding technique, treatment group 2: self etch bonding agent used with rebonding technique
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Foundation University Islamabad
Non-Small Cell Lung Cancer, EGFR Sensitive Mutation
Adjuvant Befotertinib in Stage IB-IIIB Non-small Cell Lung Cancer With Positive EGFR Sensitive Mutations
This multicenter, randomized, controlled, double-blind, double-simulated, Phase III study is designed to evaluate the efficacy and safety of Befotertinib compared with Icotinib as adjuvant treatment in EGFR-sensitive…
- Conditions
- Non-Small Cell Lung Cancer, EGFR Sensitive Mutation, Adjuvant Therapy
- Trial name
- NCT06041776
- Where
- 3 sites in China
- Volunteers
- 570 people
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Colon Cancer, Rectal Cancer
Drug Sensitivity Detection of Micro Tumor (PTC) to Guide Postoperative Adjuvant Treatment Strategy of Colorectal Cancer
The research objectives is to compare vitro 3D drug sensitivity test results of micro tumor (PTC) with the clinical outcomes of patients, evaluate the consistency between the test results of the technology platform and the…
- Conditions
- Colon Cancer, Rectal Cancer, Chemotherapy Effect, PTC
- Trial name
- NCT05424692
- Testing
- 5-fluorouracil + formyltetrahydrofolate/Oxaliplatin + 5-fluorouracil + formyltetrahydrofolate/Irinotecan + 5-fluorouracil + formyltetrahydrofolate/Cetuximab + 5-fluorouracil + formyltetrahydrofolate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Heart Disease, Anemia
The Role of Concomitant Diseases in Postoperative Complications Risk Stratification.
Study is conducted to assess the prevalence and structure of comorbidity among patients undergoing abdominal surgery and produce the stratification of the risk of postoperative complications by identifying independent predictors…
- Conditions
- Coronary Heart Disease, Anemia, Bronchial Asthma, Stroke
- Trial name
- STOPRISK (NCT03945968)
- Where
- 38 sites in Russia
- Volunteers
- 16,000 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Dentin Hypersensitivity, Post Operative Sensitivity Control
Dipotassium Oxalate for Postoperative Sensitivity in NCCLs
Postoperative sensitivity is a common complication following Class V composite restorations, particularly in non-carious cervical lesions (NCCLs).
- Trial name
- DIPOX-RCT (NCT07540299)
- Testing
- Dipotassium Oxalate Gel
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Gastric and Cardia Adenocarcinomas
Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study
Some subtypes of gastric and cardia tumors such as adenocarcinoma or gastric linitis with disseminated cells respond poorly to the pre-operative chemotherapy, and some of them do not respond to chemotherapy usually performed.
- Trial name
- NCT02491840
- Testing
- Biopsy
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Post-operative Sensitivity, Dentin Hypersensitivity
Gluma Compared With Bonding Agent for Post-operative Sensitivity Following Composite Restorations
The aim of this study is to compare the effectiveness of Gluma desensitizer in reducing post-operative sensitivity following composite restorations in posterior teeth.
- Conditions
- Post-operative Sensitivity, Dentin Hypersensitivity, Dental Caries, Tooth Sensitivity After Composite Restorations
- Trial name
- NCT07188142
- Testing
- Drug/Agent: Gluma Desensitizer, Drug/Agent: No desensitizer (Control)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Beenish Hassan
To Compare Post Operative Sensitivity
Comparison of Postoperative Sensitivity Following Bulk-Fill and Conventional Incremental Composite Restorations: This Study Will be Proceed at Tertiary Care Hospital of Peshawar
When a dentist fills a cavity, regular filling material shrinks as it hardens and cannot be penetrated deeply by the curing light, forcing dentists to painstakingly apply it in tiny 2 mm layers to prevent it from pulling away…
- Trial name
- NCT07765901
- Testing
- conventional incremental composite, bulk-fill composite
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Prime Foundation
Dental Restoration Failure, Postoperative Hypersensitivity
The Effect of Decoupling With Time Technique on the Clinical Performance of Proximal Posterior Composite Restorations
This randomized clinical trial will evaluate whether the decoupling with time technique improves the clinical performance of Class II posterior composite restorations compared with conventional composite restoration techniques.
- Trial name
- DWT (NCT07917572)
- Testing
- Decoupling With Time Technique, Conventional Composite Restoration
- Volunteers
- 50 people
- Sponsor
- Cairo University