Clinical trials: Post-partum Depression
Severe Postpartum Depression
A Study to Evaluate SAGE-547 in Participants With Severe Postpartum Depression
This is a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the efficacy, safety, and pharmacokinetics of SAGE-547 Injection in adult female participants diagnosed with severe postpartum…
- Trial name
- NCT02614547
- Testing
- SAGE-547
- Where
- 4 sites in United States
- Volunteers
- 21 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Perinatal Depression, Postpartum Depression
Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study
During this project the investigators will develop and pilot test a companion intervention for fathers (Fathers and Babies-FAB), to supplement the Mothers and Babies Course (MB) that provides stress and mood management tools for…
- Conditions
- Perinatal Depression, Postpartum Depression, Depression
- Trial name
- NCT03427528
- Testing
- Fathers and Babies (FAB), MB 1-on-1 plus TXT
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Depression, Postpartum Depression
Personalized Integrated Chronotherapy for Perinatal Depression
Perinatal depression and anxiety are common, serious, and frequently overlapping disorders that increase morbidity and mortality in new mothers (including suicide) and result in poor infant/child outcomes.
- Conditions
- Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation
- Trial name
- NCT04364646
- Testing
- Personalized Integrated Chronotherapy
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Postpartum Depression, Parenting
Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms
The purpose of this study is to determine whether a social media-based parenting program can improve responsive parenting among mothers with Postpartum depression (PPD) symptoms.
- Conditions
- Postpartum Depression, Parenting, Parent-Child Relations
- Trial name
- NCT04045132
- Testing
- Social Media-Based Parenting Program, MoodGym
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Children's Hospital of Philadelphia
Depressive Disorder, Depression
A Clinical Trial of Oral Ganaxolone in Women With Postpartum Depression
A clinical study to evaluate safety, tolerability and efficacy of oral administration of ganaxolone in women with postpartum depression
- Conditions
- Depressive Disorder, Depression, Depression, Postpartum, Behavioral Symptoms
- Trial name
- NCT03460756
- Testing
- Ganaxolone
- Where
- 33 sites in United States
- Volunteers
- 84 people
- Sponsor
- Marinus Pharmaceuticals
Health Attitude, Knowledge, Attitudes, Practice
Development and Pilot Test of a Postnatal mHealth Intervention - Phase 2
The goal of the study is to assess the feasibility and acceptability of the optimized MeSSSSage intervention which was developed and revised based on the results of our initial pilot testing.
- Conditions
- Health Attitude, Knowledge, Attitudes, Practice, Post Partum Depression, Acceptability of Health Care
- Trial name
- MESSAGE (NCT04693585)
- Testing
- MESSSSAGE - live, MESSSSAGE - asynchronous
- Where
- India
- Volunteers
- 201 people
- Sponsor
- University of California, San Francisco
Emotional Disturbances, Depression
Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women
The overall purpose of this application is to evaluate the efficacy of an intervention designed to decrease health disparities in pregnant, emotionally distressed, minority women.
- Conditions
- Emotional Disturbances, Depression, Pregnancy Late, Post-Partum Depression
- Trial name
- A-RCT (NCT03416010)
- Testing
- COPE-P
- Where
- 3 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Postpartum Depression, Depression
Clinical Trial of Estrogen for Postpartum Depression
This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). PPD causes significant distress to a large number of women; the demand for effective therapies to treat PPD is considerable.
- Trial name
- NCT00059228
- Testing
- 17beta Estradiol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Postpartum
Minimum Intervention to Maintain a Postpartum Depression Prevention Program in Clinics Serving Low-income Women
Postpartum depression (PPD) is common and can have lasting consequences for mother and child. ROSE is an intervention to prevent PPD, delivered during pregnancy in outpatient prenatal settings.
- Trial name
- ROSE (NCT03267563)
- Testing
- EIAU, LICF, HICF
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Michigan State University
Postpartum Pain, Postpartum Depression
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.
- Conditions
- Postpartum Pain, Postpartum Depression, Opioid Consumption
- Trial name
- NCT04017442
- Testing
- Preservative Free Morphine, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Pregnancy Related, Burnout, Professional
The 4th Trimester Initiative: The Impact of Parental Support on Pregnant Trainee Wellbeing
The goal of this clinical trial is to determine the impact of a parental support package for new trainee mothers which focuses on mentorship, lactation, and sleep, and access to perinatal care.
- Conditions
- Pregnancy Related, Burnout, Professional, Wellness, Psychological
- Trial name
- NCT06014892
- Testing
- Snoo smart bassinet, Willow wearable breast pump, Maven Clinic on-demand perinatal consultation
- Where
- 7 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Postpartum Depressive Disorder
Quetiapine in Postpartum Depression
The purpose of the study is to evaluate the efficacy and tolerability of quetiapine in female patients with postpartum depressive disorder with psychotic symptoms
- Trial name
- NCT00681668
- Testing
- Quetiapine
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- AstraZeneca
Anxiety, Depression
Efficacy of CES in New Mothers During the Post Partum Period
The birth of a child is a major life event that can be filled with excitement, anticipation and joy. However, the transition and adaptation to new demands, roles, responsibilities, and changes in relationships can be stressful…
- Conditions
- Anxiety, Depression, Insomnia, Sleep Quality
- Trial name
- NCT03210155
- Testing
- Alpha-Stim AID CES (Active Comparator)
- Where
- 2 sites in United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Christina Murphey, RN, PhD
Contraception, Postpartum Depression
Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression
The investigators plan to enroll 184 women who are planning to breastfeed and use DMPA after delivery to find out whether the timing of postpartum administration of DMPA (prior to hospital discharge or 4-6 weeks after delivery)…
- Conditions
- Contraception, Postpartum Depression, Lactation
- Trial name
- DEPO-ABCD (NCT01463202)
- Testing
- Depot medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Beatrice Chen
Post Partum Depression
Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum Depression
Postpartum depression is a non-psychotic major or minor depressive episode that occurs during pregnancy or within 12 months of post-partum period.
- Trial name
- NCT04011592
- Testing
- Ketamine 0.5 mg/kg, Ketamine 0.2 mg/kg
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perinatal Depression, Post Partum Depression
Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model
The proposed study involves experimentally manipulating reproductive hormones in nonpregnant, euthymic women to create a scaled down version of the changes that occur during pregnancy and the postpartum period.
- Conditions
- Perinatal Depression, Post Partum Depression, Depression, Postpartum, Depression
- Trial name
- NCT04051320
- Testing
- Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Perinatal Depression, Postpartum Depression
A Pilot Randomized Trial of Video-based Family Therapy for Depressed Home Visited Mothers
Depressed mothers (pregnant and post-delivery) make up a significant portion of Maternal, Infant, and Early Childhood Home Visiting (MIECHV) clients.
- Conditions
- Perinatal Depression, Postpartum Depression, Family Conflict
- Trial name
- NCT04741776
- Testing
- Resilience Enhancement Skills Training, Problem-Solving Individual Therapy
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Postpartum Depression, Parenting
Social Media Intervention for Postpartum Depression
This study is intended to compare the acceptability and feasibility and explore outcomes related to two different formats of a parenting program for mothers with postpartum depressive symptoms.
- Trial name
- NCT02355067
- Testing
- Social Media Intervention, Traditional In-Person Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia