Clinical trials: Post-partum Pain
Contraception
Postplacental Intrauterine Device Insertion: A Mixed Methods Assessment of Women's Experience
The primary objective of this mixed methods pilot study is to understand women's experiences with postplacental intrauterine device (IUD) insertion through postpartum semi-structured interviews.
- Trial name
- PIPPI (NCT02312726)
- Testing
- Postplacental IUD insertion
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Post-operative Pain, Post-partum Pain
Increased Ketorolac Administration After Cesarean Section and Its Effect on Opioid Use: a Randomized Control Trial
To evaluate the efficacy of increased ketorolac in reducing opioid use after cesarean section.
- Conditions
- Post-operative Pain, Post-partum Pain, Cesarean Section Complications
- Trial name
- NCT03678675
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Pain, Postoperative, Depression, Postpartum
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design.
- Trial name
- NCT05907213
- Testing
- Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Pain Management, Vaginal Delivery
Post-partum Non-pharmacologic Pain Management
This study aims to examine whether use of an abdominal binder for postpartum patients after vaginal delivery can effectively manage their pain and reduce the need for pharmacologic analgesics.
- Trial name
- NCT03903172
- Testing
- Abdominal binder
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Wright State University
Postoperative Pain
PK and Safety After C-Section
The main goal of the study was to measure the amount of the active ingredients and other components of HTX-011 in plasma and expressed breast milk over time following postpartum administration in women undergoing a planned…
- Trial name
- NCT03955211
- Testing
- HTX-011, ZYNRELEF kit components for administration, MMA regimen
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Heron Therapeutics
Complications; Cesarean Section, Pregnancy
Mobius® Post-cesarean Pain Randomized Control Trial
The purpose of this study is to investigate whether the use of the Mobius® retractor decreased post-operative pain after cesarean section verses conventional retractor use.
- Trial name
- NCT00685932
- Testing
- Mobius Retractor
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Abbey Hardy-Fairbanks
Postpartum Pain, Postpartum Depression
Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery
Patients presenting for normal spontaneous vaginal delivery who have a neuraxial anesthestic will be randomized to receive preservative free morphine or saline placebo after delivery.
- Conditions
- Postpartum Pain, Postpartum Depression, Opioid Consumption
- Trial name
- NCT04017442
- Testing
- Preservative Free Morphine, Saline
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Opioid Use, Pain, Postoperative
Ibuprofen and Acetaminophen Versus Ibuprofen and Acetaminophen Plus Hydrocodone for Analgesia After Cesarean Section
Postpartum patients delivered by cesarean section will be randomized to NSAIDS Vs NSAIDS plus opioid
- Trial name
- IVY (NCT03372382)
- Testing
- Ibuprofen, Acetaminophen, Norco
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Pain, Postpartum Depression
Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries
Obstetric anal sphincter injuries (OASIS) encompass both third and fourth degree perineal tears. These tears can have a significant impact on women's quality of life in the short and long term.
- Trial name
- NCT03470675
- Testing
- Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Northwestern University
Headache
Treatment of Post-dural Puncture Headache in Postpartum Patients: Sphenopalatine Ganglion Block to Epidural Blood Patch.
The purpose of this research study is to compare the effectiveness of a sphenopalatine ganglion block to an epidural blood patch for post-dural puncture headache relief in randomized postpartum parturients over a 48 hour period.
- Trial name
- NCT02962427
- Testing
- Sphenopalatine ganglion Block, Epidural blood patch
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver
Pain, Postoperative, Anxiety
Healing Touch After Cesarean
Pain and anxiety are the most common complications after cesarean birth, and impair the mother's ability to optimally care for herself and her newborn.
- Conditions
- Pain, Postoperative, Anxiety, Postpartum Complication
- Trial name
- NCT05053360
- Testing
- Healing Touch, Control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Inova Health Care Services
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Pain
Battlefield Auricular Acupuncture for Control of Post-partum Pain
We will conduct a randomized controlled trial to determine whether the addition of battlefield auricular acupuncture to standard of care is effective for control of postpartum pain for mothers in the immediate post-partum period.
- Trial name
- NCT02526186
- Testing
- Battlefield Auricular Acupuncture
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mike O'Callaghan Military Hospital
Pain
Epidural Morphine Following Vaginal Delivery
The investigators believe that pain management following a vaginal delivery can be improved. Many women receive epidural medication during labor and delivery, and the investigators felt that using the epidural following delivery…
- Trial name
- NCT00803114
- Testing
- Preservative-free epidural morphine
- Where
- Canada
- Volunteers
- 228 people
- Sponsor
- Mount Sinai Hospital, Canada
Pain
Assessing Maternal Post-partum Pain With Suppositories
This trial will evaluate whether the routine use of belladonna/opium (B\&O) suppositories improve patients' self-reported pain control in the first 24-hours after delivery.
- Trial name
- CRAMPS (NCT01271855)
- Testing
- Belladonna and opioid suppository, Glycerin Suppository
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Loyola University
Analgesia, Obstetrical, Postpartum Hemorrhage
Prospective Effect of Intravenous Ketorolac on Opioid Use, EBL and Complications Following Cesarean Delivery
In this randomized, double-blind control trial to evaluate the effect of ketorolac given at the time of cord clamp has on estimated blood loss and postcesarean pain control.
- Conditions
- Analgesia, Obstetrical, Postpartum Hemorrhage, Opioid Use, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT02509312
- Testing
- Ketorolac
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Postpartum Hemorrhage, Pain
Do Elastic Abdominal Binders Reduce Post Operative Pain and Blood Loss?
This is a pilot study investigating the use of abdominal binders after cesarean sections. The researchers are testing whether elastic abdominal binders improve postoperative pain control and reduce postoperative blood loss.
- Trial name
- NCT01786330
- Testing
- Procare abdominal binder, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zachary Kuhlmann, DO
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS