Clinical trials: Post-stroke, open to volunteers
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Foot Drop, Stroke
Ankle Robotics After Stroke
The randomized study (in Phase II of the U44) compares the efficacy and durability of 9 weeks (18 sessions) of robot-assisted physical therapy (PTR) versus physical therapy (PT) alone on foot drop as assessed by gait biomechanics…
- Conditions
- Foot Drop, Stroke, Hemiparesis
- Trial name
- NCT04594837
- Testing
- PTR Physical Therapy while wearing Robot group (Phase II), Physical Therapy Only (Phase II), Cross over group for Physical Therapy n Sub-Acute group. (Phase II)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- NextStep Robotics Inc.
Ischemic Stroke
Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome
Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and…
- Trial name
- NCT06735898
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- POLYSAN Scientific & Technological Pharmaceutical Company
Chronic Ischemic Stroke
A Study of ASP2246 for People Who Have Movement Problems Caused by Brain Injury After a Stroke
This study is for adults who have difficulty moving a few months after a stroke. In this study, ASP2246 will be given to people for the first time. This is known as a "first in human" study.
- Trial name
- NCT07318714
- Testing
- ASP2246, Brain surgery, Rehabilitation therapy
- Where
- 5 sites in Japan
- Volunteers
- 84 people
- Sponsor
- Astellas Pharma Inc
Ischemic Stroke
A Study to Monitor Safety and Effectiveness of Approved J&J MedTech Devices in the Treatment of Participants With Ischemic Stroke
The purpose of this study is to collect medical information to monitor the ongoing safety of the J\&J MedTech devices and to understand how well they work when routinely used to treat participants with acute ischemic stroke (a…
- Trial name
- POSEIDON (NCT07760649)
- Volunteers
- 5,000 people
- Sponsor
- Neuravi Limited
Acute Ischemic Stroke
ARTEMIS: UC-MSCs After Mechanical Thrombectomy for Acute Ischemic Stroke
This study will evaluate the safety and feasibility of administering umbilical cord-derived mesenchymal stromal cells (UC-MSCs) following mechanical thrombectomy in adults with acute ischemic stroke.
- Trial name
- ARTEMIS (NCT07913282)
- Testing
- Allogeneic Umbilical Cord-Derived Mesenchymal Stromal Cells (UC-MSCs), Standard Stroke Care Including Mechanical Thrombectomy
- Where
- Iran
- Volunteers
- 10 people
- Sponsor
- Royan Stem Cell Technology Company
Intracranial Aneurysm, Brain Arterial Disease
Safety, Performance and Usability of BALT Medical Devices: The EVIDENCE Post Marketing Clinical Follow-up Platform
BALT has designed an electronic platform to continue collecting clinical data as part of the post-marketing clinical follow-up of its devices.
- Conditions
- Intracranial Aneurysm, Brain Arterial Disease, Acute Ischemic Stroke, Peripheral Vascular Diseases
- Trial name
- EVIDENCE (NCT04927156)
- Testing
- BALT medical devices
- Where
- 12 sites in France, Germany and 1 more
- Volunteers
- 10,000 people
- Sponsor
- Balt Extrusion
Acute Ischemic Stroke, rhTNK-tPA
Observational Study to Assess the Safety of rhTNK-tPA (Mingfule®) vs. Rt-PA (Actilyse®) in Treating Acute Ischemic Stroke
This is a multicenter, prospective, non-randomized, post-marketing safety surveillance cohort study with rt-PA (Actilyse®) as the control.
- Trial name
- NCT07519889
- Testing
- rhTNK-tPA, rt-PA
- Volunteers
- 4,500 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Stroke, Stroke Rehabilitation
Personalised Health Motor and Cognitive Assistance System for RehAbilitation (PHRASE)
This study is a multicentric randomized controlled trial evaluating the effectiveness of digital technology, specifically a smartphone with integrated VR-and AR-based intervention, for at-home rehabilitation after stroke.
- Conditions
- Stroke, Stroke Rehabilitation, Chronic Stroke Patients, Post Stroke Recovery
- Trial name
- PHRASE-2024 (NCT06885502)
- Testing
- RGS
- Where
- 2 sites in Romania, Spain
- Volunteers
- 70 people
- Sponsor
- Eodyne Systems SL
Stroke, Hemiparesis After Stroke
Prospective Real-World Evidence Study of the IpsiHand® System in Adult Stroke Survivors
This study focuses on monitoring real-world customers who have been prescribed the IpsiHand® as part of their rehabilitation post-stroke.
- Conditions
- Stroke, Hemiparesis After Stroke, Brain Computer Interface
- Trial name
- NCT07147881
- Testing
- IpsiHand
- Volunteers
- 100 people
- Sponsor
- Neurolutions, Inc.
Cardiovascular Events, MACE
Tezspire Cardiac Events PASS
The aim of this study is to evaluate the risk of serious adverse cardiovascular events in adolescent and adult patients with severe asthma taking tezepelumab compared to a population receiving standard of care treatment for…
- Trial name
- TRESPASS (NCT06951867)
- Testing
- Tezepelumab
- Where
- 4 sites in United States, Denmark and 2 more
- Volunteers
- 16,640 people
- Sponsor
- AstraZeneca
Stroke
Evaluation of the Benefit of the H'Ability Home Device Used in Supervised Self-rehabilitation at Home on the Autonomy of Post-stroke Patients
The goal of this clinical investigation is to evaluate the benefit of the H'Ability Home device used in supervised self-rehabilitation at home on the autonomy of post-stroke patients.
- Trial name
- NCT07202520
- Testing
- IVR : H'Ability Home, Control: paper-based exercise guide
- Where
- 5 sites in France
- Volunteers
- 44 people
- Sponsor
- H'ability
Spasticity Post Stroke
Spinal Cord Stimulation for Poststroke Spasticity
The goal of this clinical trial is to learn whether spinal cord stimulation (SCS) is effective in treating post-stroke spasticity in adults. It will also evaluate the safety of the implanted SCS system.
- Trial name
- SCS-PSS (NCT07744659)
- Testing
- Active spinal cord stimulation
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Stroke, Stroke Acute
Research on the Effectiveness of Neurorehabilitation After Stroke
This clinical trial aims to investigate the effectiveness of a novel neurorehabilitation technology for treating stroke in adults.
- Conditions
- Stroke, Stroke Acute, Stroke with Hemiparesis, Stroke, Acute
- Trial name
- NCT06753006
- Testing
- Neurorehabilitation simulator, Standard course
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- Neurotechnika
Post-stroke Aphasia
Neurostimulation for the Treatment of Post-Stroke Aphasia
The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.
- Trial name
- NCT05194566
- Testing
- tACS
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- QVITI S.A.
Stroke, PFO - Patent Foramen Ovale
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a…
- Trial name
- REDUCE PAS (NCT03821129)
- Testing
- PFO closure with GORE® CARDIOFORM Septal Occluder
- Where
- 45 sites in United States
- Volunteers
- 636 people
- Sponsor
- W.L.Gore & Associates
Acute Ischemic Stroke
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke).
- Trial name
- TENACITY (NCT07361302)
- Testing
- Tenecteplase, Standard of care treatment
- Where
- 257 sites in Argentina, Australia and 14 more
- Volunteers
- 1,325 people
- Sponsor
- Boehringer Ingelheim
Cerebral Stroke
Telerehabilitation Early After Stroke
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke.
- Trial name
- NCT05625438
- Testing
- HandyMotion Treatment Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TRCare, Inc.