Clinical trials: Post-stroke Arm Spasticity
Upper Limb Spasticity
Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Adult Upper Limb Spasticity
This is a randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Ranging, trial to Evaluate the Efficacy and Safety of DaxibotulinumtoxinA for Injection for the Treatment of Upper Limb Spasticity in Adults After…
- Trial name
- JUNIPER (NCT03821402)
- Testing
- DAXI for injection 250 U, DAXI for injection 375 U, DAXI for injection 500 U
- Where
- 26 sites in United States
- Volunteers
- 83 people
- Sponsor
- Revance Therapeutics, Inc.
Post-stroke Arm Spasticity
Arm Spasticity - Non-Interventional Study Early BIRD (BoNT Treatment: Initial and Repeated Documentation)
Botulinum toxin A (BoNT-A) is effective and safe in alleviating post-stroke spasticity and reducing the burden of associated symptoms.
- Trial name
- EARLYBIRD (NCT01840475)
- Where
- 5 sites in Austria, France and 3 more
- Volunteers
- 302 people
- Sponsor
- Ipsen
Stroke, Spasticity, Muscle
Individualized rTMS Based on fNIRS to Spasticity
Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction.
- Conditions
- Stroke, Spasticity, Muscle, Rehabilitation
- Trial name
- NCT05318586
- Testing
- individual rTMS based on fNIRS, Traditional rTMS strategy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Upper Limb Spasticity Post-Stroke
Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke
This study aims to estimate the costs of botulinum toxin A utilization in standard practice for the treatment of upper limb spasticity post-stroke in Portugal.
- Trial name
- P_Dysport_CS (NCT02384330)
- Where
- 3 sites in Portugal
- Volunteers
- 57 people
- Sponsor
- Ipsen
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Muscle Spasticity, Stroke
Study Evaluating MyoRegulator® Treatment in Post-Stroke Upper Limb Spasticity
This is a multi-center, randomized, double-blind (patient and evaluator), sham-controlled study to be conducted in stroke patients with upper-extremity spasticity.
- Trial name
- RECOVER (NCT04742257)
- Testing
- MyoRegulator® device
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- PathMaker Neurosystems Inc.
Post-stroke Upper Limb Spasticity
Safety and Efficacy of CKDB-501A in Subjects With Post-stroke Upper Limb Spasticity
Multicenter, randomized, double-blind, active-controlled, parallel-design study to evaluate the safety and efficacy of CKDB-501A in Subjects with Post-stroke Upper Limb Spasticity
- Trial name
- NCT05382767
- Testing
- CKDB-501A, Botox®
- Where
- 2 sites in South Korea
- Volunteers
- 24 people
- Sponsor
- CKD Bio Corporation
Stroke
Biofeedback After Stroke
Studies show that the use of electromyographic biofeedback combined with other therapies contributes to the reduction of upper limb spasticity after stroke.
- Trial name
- NCT07149129
- Testing
- Electromyographic Biofeedback
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Universidade Federal do Paraná
Stroke, Upper Limb Spasticity
Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression
The purpose of this study is to investigate if early administration (i.e. within 12 weeks after stroke) of Dysport® 500 U injections may delay the appearance or the progression of upper limb symptomatic spasticity.
- Trial name
- ONTIME Pilot (NCT02321436)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Malaysia, Philippines and 2 more
- Volunteers
- 42 people
- Sponsor
- Ipsen
Upper Limb Spasticity
Efficacy and Safety Study of Botulinum Neurotoxin A With Rehabilitation Versus Botulinum Neurotoxin A Alone in Treatment of Post-stroke Spasticity
The purpose of this study is to determine if a combination of botulinum neurotoxin A and rehabilitation therapy is better than botulinum neurotoxin A alone for improvement in function based on the Fugl-Meyer and other validated…
- Trial name
- NCT00945295
- Testing
- Botulinum toxin type A, BoNT-A, Rehabilitation Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- JoAnn Harnar
Stroke, Muscle Spasticity
Altering Activation Patterns Post-stroke
This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased…
- Conditions
- Stroke, Muscle Spasticity, Hemiparesis
- Trial name
- NCT02418949
- Testing
- Cyproheptadine, Active Movement Practice (AMP), Passive Cyclical Stretching
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Shirley Ryan AbilityLab
Post-Stroke Upper Limb Spasticity
Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity
Botulinum toxin type A (BoNT-A) is widely used in the clinics to reduce spasticity and improve upper limb function for post-stroke patients.
- Trial name
- NCT03131791
- Testing
- Shock Wave, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Mackay Memorial Hospital
Stroke, Spasticity, Muscle
FlexWave Trial: Efficacy of Extracorporeal Shock Wave Therapy in Post-Stroke Upper Limb Spasticity
Extracorporeal shock wave therapy (ESWT) has emerged as an effective therapeutic intervention for addressing post-stroke limb spasticity.
- Trial name
- NCT06365476
- Testing
- focused extracorporeal shock wave therapy (ESWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Hemiplegia
HEMITOX : Effect of Botulinum Toxin Injections on Motor and Functional Ability of Upper Limb in Adults at Earlier Phases of Spastic Hemiplegia After Stroke
Botulinum toxin produced beneficial effects in spasticity in the hemiplegic upper limb. This study will test if botulinum toxin injections at earlier phases (<or = 3 months) in spasticity improve functional and motor tests…
- Trial name
- NCT00276185
- Testing
- Time delay treatment of botulinum toxin
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Spasticity, Post-Stroke
The Effect of Low-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) in Stroke Patients
In this study, we aimed to demonstrate the effects of 1 Hz rTMS applied to the contralesional hemisphere on upper extremity spasticity, spinal excitability, and additionally on motor recovery in stroke patients in the chronic…
- Trial name
- NCT06889922
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ankara City Hospital Bilkent
Stroke
Robot Aided Rehabilitation - Multi-joint Evaluations
Sensory and motor impairments following stroke can lead to substantial disability involving the arm and hand. The investigator hypothesized that excessive local and cross-coupled stiffness, diminished individuation and…
- Trial name
- Aim1 (NCT02359812)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Upper Limb Spasticity
BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity
In this study, we will compare BOTOX® versus Zanaflex ® for the treatment of muscle overactivity in the upper limb following stroke or brain traums.
- Trial name
- NCT00430196
- Testing
- BOTOX®, Zanaflex®
- Volunteers
- 135 people
- Sponsor
- Icahn School of Medicine at Mount Sinai