Clinical trials: Post-stroke Upper Limb Spasticity
Cerebrovascular Accident, Muscle Spasticity
Effects on Quality of Life Following Dysport Treatment in Post-stroke Spasticity of the Arm
The main purpose of this study is to assess the effect on Quality of Life of two cycles of Dysport treatment on post-stroke spasticity of the upper limb. The effect of treatment on spasticity and function will also be measured.
- Trial name
- NCT00216411
- Testing
- Botulinum toxin type A
- Where
- 6 sites in Australia
- Volunteers
- 96 people
- Sponsor
- Ipsen
Stroke, Upper Extremity Dysfunction
REHABOTICS: Physiotherapy for Hand Spasticity After Stroke Using Robotics and AR Serious Games
Rehabotics is a comprehensive rehabilitation system designed to deliver individualized upper-limb therapy for patients with motor impairments, particularly after stroke.
- Conditions
- Stroke, Upper Extremity Dysfunction, Spasticity Post Stroke
- Trial name
- NCT07468149
- Testing
- Rehabotics Physiotherapy
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Pantelis Syringas
Muscle Spasticity
CORETOX® in Treatment of Post Stroke Upper Limb Spasticity (Phase1)
The purpose of this study is to evaluate the safety and pharmacodynamic of CORETOX® in the treatment of post-stroke upper limb spasticity
- Trial name
- NCT05164003
- Testing
- CORETOX®, BOTOX®
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Medy-Tox
Cerebrovascular Disorders, Spasticity, Muscle
The Effect of Ultrasound-Guided Botulinum Toxin Injections on Pain, Functionality, Spasticity, and Range of Motion in Patients With Post-Stroke Upper Extremity Spasticity
The patients between the ages of 35-80 who developed spasticity in the upper extremity after stroke will be included.. Botulinum toxin(BT-A) injection will be applied to the study group(n=16) and placebo injection to the control…
- Conditions
- Cerebrovascular Disorders, Spasticity, Muscle, Botulinum Toxin
- Trial name
- NCT05887479
- Testing
- Botulinum toxin type A, %0,9 NaCl
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Stroke
Acute Effect of Mirror Therapy on Rehabilitation of Paretic Upper Extremity After Chronic Stroke
Objective: To investigate the acute effect of mirror therapy (MT) on motor control, manual dexterity and spasticity of the paretic upper extremity (UE) of individuals with chronic hemiparesis after stroke, during reaching task.
- Trial name
- NCT03371290
- Testing
- Mirror Therapy, Control Intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Upper Limb Spasticity Post-Stroke
Phase 1 Trial of JTM201 in Subjects With Post-stroke Upper Limb Spasticity
Phase 1 trial to evaluate the safety and efficacy of JTM201 compared with 'Botox® Inj.' in subjects with post-stroke upper limb spasticity
- Trial name
- NCT07292025
- Testing
- JTM201 in normal saline, BOTOX 100U in normal saline
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Jetema Co., Ltd.
Ischemic Stroke, Hemorrhagic Stroke
Goal Attainment Scaling in Upper Limb Spasticity Treatment
Patients after stroke with upper limb spasticity treated with botulinum toxin-A (BTX-A) will be included in this two-part study.
- Trial name
- GASBTX (NCT04975646)
- Testing
- Prescribed exercise program
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Upper Limb Spasticity
Study of Intramuscular Injections of ABBV-950 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Upper Limb Spasticity
Spasticity is often observed as muscle tightness and stiffness in the upper and/or lower limbs. Upper limb spasticity can interfere with joint movement and its severity can range from mild to severe.
- Trial name
- NCT05956509
- Testing
- ABBV-950, BOTOX
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- AbbVie
Post-Stroke Spasticity
A Pilot Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants With Post-Stroke Spasticity (The STIPS Study)
The goal of this clinical trial is to learn if the drug BMS-986368 works to treat post stroke spasticity in adults who have had a stroke.
- Trial name
- STIPS (NCT07704840)
- Testing
- Administration of BMS-986368
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Alberto Esquenazi
Post-Stroke Spasticity, Cerebrovascular Accident
Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity
This is a study to confirm the superior efficacy of a single treatment of GSK1358820 over placebo in patients with post-stroke upper limb spasticity of both the wrist and finger flexors using the Modified Ashworth Scale (MAS)…
- Trial name
- NCT00460564
- Testing
- GSK1358820
- Where
- 18 sites in Japan
- Volunteers
- 109 people
- Sponsor
- GlaxoSmithKline
Spasticity, Muscle, Stroke Sequelae
Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)
Assessing the objective measurement of passive joint mobility (ROM) in the spastic upper limb with Jost's pattern III in patients with post-stroke spasticity after infiltration with BoNT-A allows to objectify the increase in…
- Conditions
- Spasticity, Muscle, Stroke Sequelae, Movement Disorders
- Trial name
- ROM-ICTUS (NCT05151874)
- Testing
- Abobotulinum toxin A
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Post Stroke Scapular Dyskinesia
the Effect of Scapular Dyskinesia on the Scapular Balance Angle & Upper Extremity Sensorimotor Function in Spastic Stroke Patient. The Patients Were Diagnosed With the Lateral Scapular Slide Test, Fugl-Meyer Upper Extremity (FMUE) Scale Scores & Scapular Balance Angle Test (SBA).
to investigate the effect of Scapular dyskinesia on the scapular balance angle \& upper extremity Sensorimotor Function in spastic stroke patient.
- Trial name
- NCT04004949
- Testing
- Assessment of scapular balance angle and upper extremity sensorimotor function
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Lama Saad El-Din Mahmoud
Stroke, Muscle Spasticity
Altering Activation Patterns Post-stroke
This study evaluates a new rehabilitation approach for stroke survivors in the chronic phase of recovery in which the combination of drug therapy (cyproheptadine) and active movement practice (AMP) is used to encourage increased…
- Conditions
- Stroke, Muscle Spasticity, Hemiparesis
- Trial name
- NCT02418949
- Testing
- Cyproheptadine, Active Movement Practice (AMP), Passive Cyclical Stretching
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Cerebrovascular Stroke
The Efficacy of an Acupuncture Protocol and Use of Taping in the Treatment of Spastic Upper Limb After Stroke
The purpose of this study is to determine whether acupuncture and taping are effective in the treatment of spastic upper limb after stroke.
- Trial name
- NCT02690493
- Testing
- Acupuncture, Functional Taping, Acupuncture and Functional Taping
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Fernanda Cechetti
Stroke
Electrical Stimulation After Botulinum Toxin Injections to the Upper Extremity
The purpose of this study is to investigate the effectiveness of using electrical stimulation to improve upper extremity function in stroke survivors who receive botulinum toxin injections for spasticity.
- Trial name
- NCT04217187
- Testing
- Neuromuscular Electrical Stimulation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Texas Woman's University
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Neuro: Cerebrovascular Accident
TECAR and FES for Hand Function in Post-Stroke Spasticity
Upper-limb spasticity and impaired hand function are experienced by up to 70% of stroke survivors, which significantly restricts their independence in fulfilling daily activities.
- Trial name
- NCT07889921
- Testing
- FES therapy, TECAR therapy and FES
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- October 6 University
Stroke, Muscle Spasticity
Early Use of Botulinum Toxin in Spasticity Post Stroke.
Patients who survive a stroke are often left with an arm that cannot be used. One reason for this is that the muscles affected by the stroke become overactive. This is known as spasticity.
- Conditions
- Stroke, Muscle Spasticity, Contracture
- Trial name
- EUBoSS (NCT01882556)
- Testing
- onabotulinumtoxinA
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Stroke, Spasticity, Muscle
Individualized rTMS Based on fNIRS to Spasticity
Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction.
- Conditions
- Stroke, Spasticity, Muscle, Rehabilitation
- Trial name
- NCT05318586
- Testing
- individual rTMS based on fNIRS, Traditional rTMS strategy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University