Clinical trials: Post-surgical Pain
Postoperative Pain
Wound Infiltration With Sodium Diclofenac vs Bupivacaine for Postoperative Pain Following Appendectomy
The infiltration of the surgical wound is an effective strategy for postoperative analgesia. Nonsteroidal antiinflammatories are useful in this way.
- Trial name
- diclofenac (NCT02752971)
- Testing
- Bupivacaine, Sodium diclofenac
- Volunteers
- 43 people
- Sponsor
- Hospital Central Dr. Luis Ortega
Postoperative Pain
Study Evaluating the Safety, Efficacy and Pharmacokinetics of SYH9089 Injection in Patients Undergoing Abdominal Surgery.
This is a randomized, double-blind, active drug- and placebo-controlled, dose-escalation clinical study conducted in patients scheduled to undergo abdominal surgery.
- Trial name
- NCT07519109
- Testing
- SYH9089 injection, Ropivacaine hydrochloride, 0.9 % sodium chloride
- Where
- China
- Volunteers
- 60 people
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
Surgery, Otolaryngologic Disorder
Digital Intervention Postoperative Protocol
Postoperative recovery after head and neck surgery is complex, and often requires utilization of narcotic medications. The aim of this study is to evaluate reduction in pain and use of opioid medications through Virtual Reality…
- Conditions
- Surgery, Otolaryngologic Disorder, Pain, Postoperative
- Trial name
- NCT04828109
- Testing
- Virtual Reality, Fitbit
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Postoperative Pain
Efficacy of Erector Spinae Plane Block Analgesia After Off Pump Cardiac Surgery
In this study the investigators will investigate the efficacy of ESPB as a part of Enhanced recovery after surgery on postoperative analgesia and recovery criteria after off pump cardiac surgery.
- Trial name
- ESPB (NCT05769309)
- Testing
- Erector spinae block, Fentanyl
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Orthopedic Procedures, Pain, Postoperative
Risk Model for Severe Rebound Pain After Lower Limb Orthopedic Surgery Involving Single-Shot Sciatic Nerve Blocks
Rebound pain is a well-recognized phenomenon after the effects of a nerve block wear off. Severe rebound pain can happen after outpatient surgery, with patients often needing to come back to the hospital or use other health care…
- Conditions
- Orthopedic Procedures, Pain, Postoperative, Surgery, Nerve Block
- Trial name
- NCT05018104
- Testing
- This is not an interventional study
- Where
- Canada
- Volunteers
- 1,270 people
- Sponsor
- University of British Columbia
Pain
Pain Control After Cardiac Surgery Using Intravenous Acetaminophen
Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid consumption and/or pain intensity scores after cardiac surgery.
- Trial name
- NCT01822821
- Testing
- IV Acetaminophen
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty, Chronic Postoperative Pain
Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy. Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to…
- Trial name
- KNEE BDNF (NCT04604847)
- Testing
- blood test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Pain, Postoperative
Fixed Combination of Dipyrone and Codeine for Controlling Pain After Pelvic-abdominal Surgery
Phase III clinical trial, multicentre, superiority, randomized, open, parallel groups, with active control and use of postoperative oral medication (multiple doses of medication).
- Trial name
- DIPICOR (NCT04641338)
- Testing
- Fixed dose combination Dipyrone and Codeine, Dipyrone, Codeine
- Where
- 3 sites in Brazil
- Volunteers
- 491 people
- Sponsor
- Brazilian Clinical Research Institute
Postoperative Pain
Erector Spinae Plane Block For Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
The aim of this study was to assess the efficacy of bilateral ESPB on postoperative analgesia in patients undergoing total abdominal hysterectomy under general anesthesia.
- Trial name
- Erector Spinae (NCT03741348)
- Testing
- Erector Spinae Plane Block, control
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Post Operative Pain
Effects of Adding Dexamethasone Plus Ketamine to Bupivacine in Serrtatus Plane Block
This randomized, double-blind trial included 60 female patients undergoing modified radical mastectomy. The study carried out at National Cancer Institute, cairo university after approval of the local ethical committee.
- Trial name
- NCT05775393
- Testing
- Serratus anterior plane block for MRM
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Chest Pain
Stripping Massage After Thoracoscopy
This study investigated the effects of stripping massage (SM) on myofascial trigger points in the rhomboid after thoracoscopic surgery.
- Trial name
- SMAT (NCT04716816)
- Testing
- Stripping massage
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Anterior Cruciate Ligament Rupture, Acute Pain
Femoral Triangle + IPACK Blocks for ACL Reconstruction Analgesia
An adequate balance between analgesia and motor function is an essential requirement to facilitate functional recovery and early discharge after anterior cruciate ligament (ACL) reconstruction surgery. Proximal nerve blocks (i.e.
- Conditions
- Anterior Cruciate Ligament Rupture, Acute Pain, Pain, Postoperative, Knee Injuries
- Trial name
- NCT05068063
- Testing
- Bupivacaine Injection, normal Saline
- Where
- 2 sites in Chile
- Volunteers
- 48 people
- Sponsor
- University of Chile
Pain, Postoperative
the Role of Popliteal Plexus Block in Pain Management After Anterior Cruciate Ligament Reconstruction.
Anterior cruciate ligament (ACL) injury is traumatic and debilitating and is typically repaired using an arthroscopic technique performed as an outpatient surgical procedure.
- Trial name
- NCT04020133
- Testing
- saphenous nerve block, popliteal plexus block, Plain bupivacaine
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Fayoum University Hospital
Secondhand Smoking
COMPLICATIONS RELATED CARBOXYHEMOGLOBIN LEVELS IN SECOND HAND SMOKING PEDIATRIC TONSILLECTOMY PATIENTS
The purpose of this study was to determine whether high carboxyhemoglobin level is a risk factor for postoperative adverse events in children exposured to carbon monoxide, especially enviromental tobacco smoke.
- Trial name
- NCT01942252
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Acute Pain
Bunionectomy Study (0000-063)
We are interested in whether bunionectomy can be used as a model to study the treatment of acute pain. It has been used to study the effect of Non-Steroidal Anti-inflammatory (NSAIDS) medications (such as ibuprofen) and other…
- Trial name
- NCT00601458
- Testing
- pregabalin, naproxen sodium
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Postoperative Pain
Dexmedetomidine Wound Infiltration in Cesarean Section
The effects of four different wound infiltration protocols in cesarean section will be investigated on parturient' pain intensity, PCA morphine consumption given, side effects and parturient' overall satisfaction.
- Trial name
- NCT03382938
- Testing
- Dexmedetomidine, Ropivacaine, Dexmedetomidine - Ropivacaine
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Hypertensive Disease, Pain, Postoperative
Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy
- Trial name
- NCT01897155
- Testing
- SBP 20-30% over baseline, SBP 20-30% under baseline
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Analgesia, Pain, Postoperative
Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery
The rationale for multimodal analgesia is to achieve additive or synergistic analgesic properties while decreasing the incidence of side effects by reducing the dose of each agent.
- Conditions
- Analgesia, Pain, Postoperative, Spinal Stenosis, Spinal Disease
- Trial name
- NCT04391855
- Testing
- Tramadol with ropivacaine, Dexmedetomidine with ropivacaine, Magnesium with ropivacaine
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- Aristotle University Of Thessaloniki
Pain
Perioperative Δ9-THC for Postsurgical Pain
Adequate treatment of postsurgical pain leads to better mobilization, shorter hospital stay, lower costs and higher patient satisfaction. In its treatment, frequent use is made of opioids. However, opioids have many side-effects.
- Trial name
- NamiSur (NCT01790555)
- Testing
- Namisol
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Caries
Post-operative Pain and Child Behavior of Hall Technique Versus SDF in the Management of Carious Primary Molars: RCT
PICO question: Papulation: children suffering from caries Intervention: Silver Diamine Fluoride Comparison: Hall technique Outcome: Primary Outcome: Intraoperative and postoperative pain Measurement device: Face pain scale…
- Trial name
- NCT04794426
- Testing
- Silver diamine fluoride, Hall Technique
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Noura Mohamed Alhosaini