Clinical trials: Post-thrombotic Syndrome
Deep Venous Thrombosis, Post Thrombotic Syndrome
Catheter-directed Thrombolysis Compared to Anticoagulation Alone for Acute Primary Iliofemoral Deep Venous Thrombosis
Post-thrombotic syndrome (PTS) is a complication that can develop after deep vein thrombosis (DVT) of the lower extremities. PTS can occur at various times after the initial episode, but usually manifests within two years of…
- Trial name
- NCT04411316
- Testing
- Catheter directed thrombolysis plus anticoagulation, Anticoagulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Toledo Health Science Campus
Deep Vein Thrombosis, Venous Thrombosis
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
The purpose of this study is to determine if the use of adjunctive Pharmacomechanical Catheter Directed Thrombolysis, which includes the intrathrombus administration of rt-PA--Activase (Alteplase),can prevent the post-thrombotic…
- Conditions
- Deep Vein Thrombosis, Venous Thrombosis, Postphlebitic Syndrome, Venous Thromboembolism
- Trial name
- ATTRACT (NCT00790335)
- Testing
- Recombinant tissue plasminogen activator (rt-PA)
- Where
- 56 sites in United States
- Volunteers
- 692 people
- Sponsor
- Washington University School of Medicine
Catheter Thrombosis, Post Thrombotic Syndrome
Incidence and Characteristic of CRT Persistent After Catheter Extraction in ICU Patients
The goal of this observational study is to describe characteristics of catheter related thrombosis (CRT) that persists after catheter extraction in condition of intensive care unit. The main questions it aims to answer are: 1.
- Conditions
- Catheter Thrombosis, Post Thrombotic Syndrome, Pulmonary Embolism (Diagnosis)
- Trial name
- CRT-PERSIST (NCT07473284)
- Testing
- No Interventions
- Volunteers
- 300 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Venous Recanalisation
Clinical and Hemodynamic Evaluation After Venous Recanalization of Post-thrombotic Iliofemoral Syndromes
Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT). The endovascular recanalization and stenting technique has become the gold standard treatment for medically resistant and…
- Trial name
- CHEVROPIS (NCT05954663)
- Testing
- Basic demographic information
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Hospices Civils de Lyon
Deep Vein Thrombosis, Post-Thrombotic Syndrome
Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial
The purpose of this study is to determine if the use of adjunctive catheter-directed thrombolysis (CDT), which includes the intrathrombus administration of rt-PA (Activase/Alteplase), can prevent post-thrombotic syndrome (PTS) in…
- Conditions
- Deep Vein Thrombosis, Post-Thrombotic Syndrome, Venous Thrombosis
- Trial name
- PHLO (NCT02767232)
- Testing
- Recombinant tissue plasminogen activator (rt-PA), Standard Anticoagulation Therapy
- Sponsor
- University of Colorado, Denver
Deep Venous Thrombosis, Post-thrombotic Syndrome
Novel PET/CT and Treatment Strategies to Reduce PTS Following DVT
The goal of this study is to develop strategies that will improve outcomes for patients with deep vein thrombosis (DVT), using in vivo FDG-PET inflammation imaging to better predict the development of the post-thrombotic syndrome…
- Trial name
- NCT03195777
- Testing
- PET/CT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Post Thrombotic Syndrome, Deep Vein Thrombosis
Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)
'The PACT trial' is randomized pilot trial to demonstrate the feasibility and potential effectiveness of a personal "fitness tracker" to improve adherence to an activity regimen following an initial acute DVT in children.
- Trial name
- PACT (NCT03075761)
- Testing
- Fitbit, 30-minute education session
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Texas Southwestern Medical Center
Vaccine Adverse Reaction
Genomics and COVID-19 Vaccine Adverse Events
Vaccines routinely used are extremely safe; however, severe adverse events to vaccines do occur. As vaccination against COVID-19 has begun, adverse events to the vaccine, particularly Guillain-Barré syndrome (GBS)…
- Trial name
- NCT05212792
- Testing
- COVID-19 vaccines
- Where
- Canada
- Volunteers
- 6,325 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Post Thrombotic Syndrome
Angioplasty-stenting vs Optimal Medical Treatment on Post-thrombotic Syndrome Reduction
The project will highlight the potential benefit of endovascular therapy on post thrombotic syndrome reduction after proximal iliac DVT. There is actually not real standard of care for the treatment of this pathology.
- Trial name
- EndoPTS (NCT04250025)
- Testing
- 60 patients benefit from immediate venous angioplasty stenting plus medical treatment, i.e. elastic compression and anticoagulation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Chronic Venous Insufficiency, Chronic Venous Thrombosis
Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous Disease
Chronic obstruction of the iliac veins or inferior vena cava can occur as a result of deep vein thrombosis (DVT), or due to extrinsic compression in non-thrombotic iliac vein lesions (NIVLs).
- Conditions
- Chronic Venous Insufficiency, Chronic Venous Thrombosis, Iliac Vein Stenosis, Iliac Vein Obstruction
- Trial name
- BEST (NCT05622500)
- Testing
- Deep venous stenting, Best medical therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Deep Vein Thrombosis
Resolution Enhancement by a Supplemental Obstruction Lessening Venoactive Drug for Eight Weeks in Deep Vein Thrombosis
The RESOLVE-DVT study is a randomized single-center pilot study to determine the effects of hydroxyethylrutoside (Venoruton) on aspects of deep vein thrombosis (DVT) resolution associated with post-thrombotic syndrome (PTS).
- Trial name
- Resolve-DVT (NCT04670432)
- Testing
- Hydroxyethylrutoside
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Maastricht University Medical Center
Post-thrombotic Syndrome, Deep Vein Thrombosis Leg
Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall Fibrosis
The goal of this study is to determine the safety and tolerability or efficacy of adjunctive treatments (including rosuvastatin 20 mg daily) in combination with standard anticoagulation therapy (Factor Xa inhibitors) in patients…
- Trial name
- NCT04833764
- Testing
- Rosuvastatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Khanh Nguyen
Deep Vein Thrombosis, Post Thrombotic Syndrome
Non-elastic Compression Garment Therapy Versus Control for Deep Vein Thrombosis
The objective of the study is to conduct a Bayesian randomized trial comparing non-elastic compression garments applied with high pressure (Circaid group) with no compression (control group) in reducing signs and symptoms in the…
- Trial name
- NCT03368313
- Testing
- Circaid
- Where
- 18 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Pró Circulação®
Deep Vein Thrombosis
Deep Venous Thrombus Characteristics and Venous Dynamics With Subsequent Thrombus Resolution and Post-thrombotic Syndrome
The goal of this study is to examine in vivo thrombosis characteristics with ultrasound shear wave elastography (SWE) and determine the relationship with thrombus resolution and postthrombotic syndrome (PTS) in patients with…
- Trial name
- NCT04597138
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Post-thrombotic Syndrome
Bern Venous Stent Registry
The purpose of this study is to examine patency rates of self-expanding nitinol stents for treatment of iliofemoral and inferior vena cava residual thrombosis, obstruction or stenosis.
- Trial name
- NCT02433054
- Testing
- CE-certified dedicated venous stents
- Where
- Switzerland
- Volunteers
- 548 people
- Sponsor
- University of Zurich
Antiphospholipid Syndrome, Thrombotic Antiphospholipid Syndrome
Anticoagulant Cessation After Antiphospholipid Autoantibodies Loss in Thrombotic Antiphospholipid Syndrome
This is an open-label, non-inferiority, randomized controlled trial with two parallel arms (experimental and control), following a PROBE (Prospective Randomized Open, Blinded Endpoint) design.
- Conditions
- Antiphospholipid Syndrome, Thrombotic Antiphospholipid Syndrome, Thrombosis
- Trial name
- ADORA (NCT07875153)
- Testing
- Vitamin K Antagonist - Drug, Anticoagulant Therapy Discontinuation
- Where
- France
- Volunteers
- 234 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Deep Vein Thrombosis, Venous Stasis
Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
The purpose of this study is to determine if the use of image-guided, endovascular therapy (EVT) is an effective strategy with which to reduce Post Thrombotic Syndrome (PTS) disease severity and improve quality of life in…
- Conditions
- Deep Vein Thrombosis, Venous Stasis, Venous Insufficiency, Venous Leg Ulcer
- Trial name
- C-TRACT (NCT03250247)
- Testing
- Stents
- Where
- 29 sites in United States
- Volunteers
- 225 people
- Sponsor
- Washington University School of Medicine
Venous Thrombosis, Postthrombotic Syndrome
Ultrasound-enhanced Thrombolysis Versus Standard Catheter Directed Thrombolysis for Ilio-femoral Deep Vein Thrombosis
Patients with deep vein thrombosis (DVT) of the ilio-femoral veins have increased risk for developing post-thrombotic syndrome (PTS) and recurrent venous thromboembolism compared to more distal DVT.
- Trial name
- BERNUTIFUL (NCT01482273)
- Testing
- CDT+US group, CDT-US group
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern