Clinical trials: Post-traumatic
Critical Illness, Length of Stay
Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
- Conditions
- Critical Illness, Length of Stay, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT00466492
- Testing
- Sedation or no sedation during mechanical ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Posttraumatic Headache
Non-pharmacological Treatment of Patients at Risk of Developing Persistent Post-traumatic Headache: The PTHEENOT Study
The goal of this mixed method study is to test and evaluate the effect of an early interdisciplinary non-pharmacological treatment of patients at risk of developing persistent posttraumatic headache in order to prevent the…
- Trial name
- NCT06466499
- Testing
- The intervention group
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Post-traumatic Stress Disorder
Treatment of PTSD by Reduction of Traumatic Memory Reconsolidation by Propranolol : a Multisite Trial
The purpose of this study is to test whether propranolol, when given during a re-evocation of a traumatic memory, is capable of reducing subsequent PTSD symptoms associated with that memory.
- Trial name
- REDUCTRAUMA2 (NCT01713556)
- Testing
- Propranolol, Trauma reactivation
- Where
- 4 sites in France
- Volunteers
- 87 people
- Sponsor
- University Hospital, Toulouse
PTSD, Alcohol Use Disorder
MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder
To explore the effectiveness of of MDMA-assisted prolonged exposure therapy in improving treatment outcomes for individuals with comorbid PTSD and alcohol use disorder in a double-blind randomised placebo-controlled trial.
- Conditions
- PTSD, Alcohol Use Disorder, Alcohol Dependence, Post-traumatic Stress Disorder
- Trial name
- MPATHY (NCT05709353)
- Testing
- Prolonged exposure therapy, MDMA, Niacin
- Where
- 2 sites in Australia
- Volunteers
- 120 people
- Sponsor
- University of Sydney
Physical Disability, Depression
Prognostication of Need for Rehabilitation and Special Support in ICU Survivors
Title: PROGnostication of need for REhabilitation and Special Support after Intensive Care Unit Stay - a multinational, observational study Objectives: 1.
- Conditions
- Physical Disability, Depression, Posttraumatic Stress Disorder, Anxiety
- Trial name
- PROGRESS-ICU (NCT02679157)
- Where
- 10 sites in Denmark, Netherlands and 1 more
- Volunteers
- 573 people
- Sponsor
- Karolinska University Hospital
Rheumatoid Arthritis, Osteoarthritis
Cementless Alumina-Alumina Total Hip and Hybrid
Evaluate the safety and efficacy of the CeramTec Acetabular Alumina Insert and CeramTec Alumina head when used with the Foundation Porous Coated Acetabular Shell and an Encore hip stem.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT00764530
- Testing
- Alumina/Alumina, Standard
- Where
- 3 sites in United States
- Volunteers
- 342 people
- Sponsor
- Encore Medical, L.P.
PTSD
Pilot-Study DCPT for PTSD in Adolescents and Young Adults
The aim of this pilot study is to evaluate the developmentally adapted cognitive processing therapy (D-CPT)in adolescents suffering from childhood abuse(CA)or physical abuse (PA) related PTSD.
- Trial name
- Pilot-DCPT (NCT01870271)
- Testing
- Developmentally adapted cognitive processing therapy
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Goethe University
Posttraumatic Stress Disorder, Cannabis Use Disorder
Mitigating PTSD-CUD After Sexual Assault
683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD).
- Trial name
- RISE-C (NCT05989841)
- Testing
- RISE Guide, Relaxation Control
- Where
- 6 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of Nevada, Las Vegas
Chronic Subdural Hematoma
To Scan or Not to Scan: The Role of Follow-up CT Scanning for Management of Chronic Subdural Hematoma After Neurosurgical Evacuation
Chronic subdural hematoma (CSH) is one of the most common bleedings of the head. These hematomas develop after minor head trauma and increase in size over weeks.
- Trial name
- TOSCAN (NCT01624545)
- Testing
- cranial CT scan
- Where
- Switzerland
- Volunteers
- 368 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cervicogenic Headaches
Active and Passive Cervical Flexion-rotation Tests
Motion limitations have been previously reported in people with headaches originating from the neck/cervicogenic headaches. A test involving flexing and rotating the neck has been found useful to diagnose this type of headache.
- Trial name
- NCT02070172
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Post-traumatic Stress Disorder
Program for Alleviating and Resolving Trauma and Stress 1
This single-arm pilot study (Phase 1) will test the preliminary efficacy of a virtually delivered, live-online 16-week group model of Internal Family Systems (IFS) for individuals with PTSD, called the PARTS program, on PTSD…
- Trial name
- PARTS1 (NCT04713501)
- Testing
- PARTS Program
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Posttraumatic Stress Disorder
A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD)
This study is designed to investigate the safety of intranasal administration of NPY using a dose escalation, randomized, double-blinded, placebo-controlled crossover design in a medication-free, symptomatic PTSD group.
- Trial name
- NCT01533519
- Testing
- Neuropeptide Y
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- James Murrough
Posttraumatic Stress Disorder, Depression
Groups for Regaining Our Wellbeing (GROW)
The proposed study is a randomized, controlled trial that will assess whether two group interventions for PTSD - Mindfulness-Based Stress Reduction (MBSR) and Cognitive Processing Therapy-Cognitive only (CPT-C) result in similar…
- Trial name
- GROW (NCT01971541)
- Testing
- Mindfulness-Based Stress Reduction, Cognitive Processing Therapy
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Headache Disorders, Secondary, Brain Diseases
Hypersensitivity to Amylin in Post-Traumatic Headache
Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent…
- Conditions
- Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases
- Trial name
- NCT07340775
- Testing
- Amylin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
PTSD, Acute Stress Disorder
PTSD Prevention Using Oral Hydrocortisone
There is currently no evidence-based intervention for individuals exposed to trauma that is designed to aid recovery and prevent the development of post-traumatic stress disorder (PTSD).
- Conditions
- PTSD, Acute Stress Disorder, Trauma-related Stressor
- Trial name
- NCT04924166
- Testing
- Hydrocortisone
- Where
- 3 sites in United States, Israel
- Volunteers
- 201 people
- Sponsor
- Rachel Yehuda
Post Traumatic Stress Disorder
tDCS and Inhibitory Control in PTSD
Large samples (~2,000/yr) of adult undergraduate students at a large southern university will be pre-screened via the University of Kentucky SONA System (IRB#43626) to identify and recruit adult female participants who report a…
- Trial name
- NCT06100731
- Testing
- tDCS
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Gopalkumar Rakesh
Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder
Effects of Early Abuse on Adult Intimate Relationships
This study is designed to help us better understand the factors that affect the sexual lives of women who have been sexually mistreated during childhood.
- Conditions
- Hypoactive Sexual Desire Disorder, Female Sexual Arousal Disorder, Female Orgasmic Disorder, Major Depressive Disorder
- Trial name
- NCT01803802
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
PTSD, Autism Spectrum Disorder High-Functioning
Psychiatric Orders in Psychoanalytic Treatment of ASD
Autism Spectrum Disorder (ASD) is often accompanied by a variety of other symptoms, such as bipolar disorder, Attention Deficit Hyperactivity Disorder (ADHD), Social Anxiety Disorder (SAD), Avoidant Personality Disorder (AvPD)…
- Conditions
- PTSD, Autism Spectrum Disorder High-Functioning, OCD, Agoraphobia With Panic Attacks
- Trial name
- NCT05930912
- Testing
- Psychoanalysis, sertraline 50mg, Duloxetine 20 MG
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yang I. Pachankis, PhD
Substance Use Disorder, Post-traumatic Stress Disorder
Mindful Self Compassion for Combat Deployed Veterans With Moral Injury and Co-occurring PTSD-SUD
Veterans with co-occurring Posttraumatic Stress Disorder and Substance Use Disorder (PTSD-SUD) experience more severe symptomatology and poorer response to existing treatments than Veterans with either disorder alone.
- Conditions
- Substance Use Disorder, Post-traumatic Stress Disorder, Moral Injury
- Trial name
- NCT03681288
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
PTSD
Complementary and Alternative Interventions for Veterans With Posttraumatic Stress Disorder
The overarching aim of this proposal is to research whether meditation-based treatments are effective in decreasing posttraumatic stress disorder (PSTD) symptoms in veterans, which complementary and alternative (CA) treatments…
- Trial name
- NCT01512303
- Testing
- Sudarshan Kriya Yoga, Mindfulness-Based Stress Reduction
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
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