Clinical trials: Post-traumatic
PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA)
Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest.
- Trial name
- NCT07410481
- Testing
- Acceptance and Mindfulness Based Exposure Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Concussion; Syndrome
Feasibility of a Purpose in Life Renewal Intervention for Adults With Persistent Symptoms After Concussion
A group of clinicians and researchers developed an 8-session group intervention that integrates education, support, self-reflection, and action-expectation to help people reaffirm or reconstruct self-grounded purpose after…
- Trial name
- PSC (NCT05780658)
- Testing
- Compass Course
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mary Radomski
Cervicogenic Headache, Occipital Neuralgia
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves at the top of the neck.
- Trial name
- NCT05491915
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- SPR Therapeutics, Inc.
Post Traumatic Stress Disorder
Assessment of a Brief Post Traumatic Stress Disorder Intervention for Use in Botswana
The purpose of this study is to culturally adapt a brief psychological intervention for Post-Traumatic Stress Disorder (PTSD) and assess its efficacy, feasibility, and acceptability in a pilot trial.
- Trial name
- NCT04426448
- Testing
- Brief Relaxation, Education And Trauma HEaling
- Where
- Botswana
- Volunteers
- 36 people
- Sponsor
- University of Botswana
Post Traumatic Stress Disorder, Traumatic Brain Injury
Rapid Treatment of PTSD With Accelerated Non-Invasive Brain Stimulation
This study will test the clinical efficacy of an accelerated TMS (accel-TMS) protocol that rapidly addresses PTSD symptoms with 1 week (25 sessions over 5 days) of condensed treatment.
- Trial name
- NCT06544408
- Testing
- Cool B70 AP Coil - Active (dl-PFC), Cool D-B80 AP Coil - Active (dm-PFC), Cool B70 Treatment Coil - Active Only
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Florida State University
Cervicogenic Headache, Neck Pain
Cervicospinal Posture and Pain in Cervicogenic Headache
Cervicogenic headache (CEH) is a type of symptomatic headache that is characterized by chronic unilateral headache secondary to cervical spine dysfunction.
- Trial name
- NCT04242290
- Testing
- Lateral radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Hitit University
Osteoarthritis, Post-traumatic Arthritis
ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty
This post-marketing investigation will evaluate the mechanical axis alignment achieved with the ATTUNE Single-Use Instrumentation (SUI) as compared to the mechanical axis alignment achieved with the ATTUNE Reusable…
- Trial name
- SOLO (NCT02574312)
- Testing
- ATTUNE TKA with ATTUNE RUI, ATTUNE TKA with ATTUNE SUI
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 88 people
- Sponsor
- DePuy Orthopaedics
Post-traumatic Stress Disorder
Stellate Ganglion Block for PTSD
Posttraumatic Stress Disorder (PTSD) is a debilitating condition that affects about 15% of Veterans. Current treatments for Veterans with PTSD include medications and psychological therapies that help to process and desensitize…
- Trial name
- SGB-PTSD (NCT05169190)
- Testing
- Stellate Ganglion Block
- Where
- 6 sites in United States
- Volunteers
- 410 people
- Sponsor
- VA Office of Research and Development
Spasticity
A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity.
The purpose of the study is to assess the safety and efficacy of increasing doses of Corabotase (also known as IPN10200) with the aim to evaluate the Pharmacodynamics (PD) profile of Corabotase and to establish the total…
- Trial name
- LANTIMA (NCT04752774)
- Testing
- Corabotase, Dysport
- Where
- 81 sites in United States, Austria and 12 more
- Volunteers
- 240 people
- Sponsor
- Ipsen
Post-Traumatic Headache, Acute Pain
Titrated Versus High and Low Dose Nebulized Morphine to Reduce Pain in Emergency Settings
The investigators test a different technique using morphine to improve pain relief in patient visiting the emergency department with acute trauma pain, for this we are comparing three different methods of morphine administration…
- Trial name
- TIMORNEB (NCT02200185)
- Testing
- IV titrated morphine, Low dose nebulised morphine, High dose nebulised morphine
- Where
- Tunisia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Post-Traumatic Stress Disorder
A Phase 2b Study of BNC210 Tablet Formulation in Adults With Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to assess the effects of BNC210 compared to placebo on Post-Traumatic Stress Disorder (PTSD) symptom severity as measured by the Clinician Administered PTSD scale for The Diagnostic and Statistical…
- Trial name
- ATTUNE (NCT04951076)
- Testing
- BNC210
- Where
- 32 sites in United States, United Kingdom
- Volunteers
- 212 people
- Sponsor
- Bionomics Limited
Critical Illness
Integrated Supportive and Palliative Care for Older Adults in the ICU
The National Academy of Medicine and the National Institutes of Health have called for urgent action to improve the care delivered to the nearly 1,000,000 older Americans who die in intensive care units (ICUs) annually, or…
- Trial name
- ProPACC (NCT04921631)
- Testing
- Early Integration of Specialty Palliative Care with Critical Care
- Where
- United States
- Volunteers
- 1,091 people
- Sponsor
- University of Pittsburgh
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Traumatic Brain Injury
Advanced MRI In Acute Military TBI
Traumatic brain injury can cause permanent problems with thinking, memory, control of emotions, organization and planning. Thousands of soldiers, marines, and other military personnel have had injuries to the brain due the wars…
- Trial name
- NCT01313130
- Where
- 2 sites in United States, Germany
- Volunteers
- 400 people
- Sponsor
- Washington University School of Medicine
PTSD, Alcohol Abuse
Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD
The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD).
- Conditions
- PTSD, Alcohol Abuse, Alcohol Dependence
- Trial name
- NCT01663337
- Testing
- Cognitive Processing Therapy (CPT), Relapse Prevention (RP)
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- University of Washington
Post-Traumatic Stress Disorder
Brief Cognitive Behavioral Treatment of Deployment-Related PTSD Symptoms in Primary Care Settings
A significant number of veterans of the wars in Iraq and Afghanistan are affected by posttraumatic stress disorder (PTSD). The limited reach of effective treatments for PTSD into the veteran population is at least partially due…
- Trial name
- NCT02290639
- Testing
- Brief Cognitive Behavioral Treatment, Minimal Contact
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
PTSD, Overweight and Obesity
I MOVE!+UP: Piloting an Integrated Weight Management Program for Veterans With PTSD
This study seeks to test I MOVE!+UP, which integrates individual evidence-based psychotherapy for PTSD with behavioral weight management among Veterans with a Body Mass Index of at least 30 and meeting criteria for current PTSD.
- Trial name
- NCT05755100
- Testing
- I MOVE!+UP
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Puget Sound Health Care System
PTSD
Prolonged Exposure (PE) Treatment for Post Traumatic Stress Disorder (PTSD) 20 Minutes Versus 40 Minutes
Comparing the efficacy of 40 minutes PE treatment to 20 minutes of the same treatment
- Trial name
- NCT00229307
- Testing
- Prolonged Exposure (PE) therapy
- Where
- Israel
- Volunteers
- 39 people
- Sponsor
- Sheba Medical Center
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
Schizophrenia, Cannabis Dependence
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
The aim of the present study is to assess the availability of cannabinoid receptors (CB1R) in the human brain. CB1R are present in everyone's brain, regardless of whether or not someone has used cannabis.
- Conditions
- Schizophrenia, Cannabis Dependence, Prodromal for Psychotic Illness, Family History of Alcoholism
- Trial name
- NCT01730781
- Testing
- [11-C]OMAR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
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