Clinical trials: Post-traumatic, open to volunteers
Traumatic Brain Injury
Long-term Recovery and Microbiota-Gut-Brain Axis Disruption After Traumatic Brain Injury
The OVERCOME-TBI project aims to collect multimodal data approximately 1-4 and 11-14 years after an earlier well-documented traumatic brain injury (TBI) and examine factors that influence disease progression in order to gain new…
- Trial name
- OVERCOME-TBI (NCT06927063)
- Testing
- blood-based protein biomarker assessments, blood-based metabolomic/lipidomic biomarker assessments, Diffusion-weighted magnetic resonance imaging (brain)
- Volunteers
- 160 people
- Sponsor
- Turku University Hospital
Post Traumatic Stress Disorder
Exploring Clinical Study Experiences of People With Post Traumatic Stress Disorder
Participation in post traumatic stress disorder observational study serves as a crucial contribution to advancing medical knowledge and refining the care provided to individuals facing similar health challenges.
- Trial name
- NCT06146049
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Stress Disorders, Post-Traumatic
Computer Monitor vs Augmented Reality 3MDR for PTSD PTSD: A Randomized Controlled Trial
This is a prospective randomized controlled trial comparing two ways of delivering Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) therapy for posttraumatic stress disorder (PTSD).
- Trial name
- CARE4PTSD (NCT05244564)
- Testing
- Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
Trauma Injury, Trauma, Multiple
Effectiveness of a Self-management Program After Traumatic Injury
Traumatic injuries, defined as a physical injury with sudden onset, are a leading cause to disability and impaired health. Persons who sustain a traumatic injury often report problems in daily life activities and reduced quality…
- Conditions
- Trauma Injury, Trauma, Multiple, Polytrauma
- Trial name
- SEMPO (NCT06305819)
- Testing
- self-management support program, Control group
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Oslo University Hospital
Intimate Partner Violence
Evaluating Interventions for Intimate Partner Violence Use in Washington State
Intimate partner violence (IPV), specifically physical and psychological aggression toward an intimate partner, represents a public health crisis that affects millions of Americans each year.
- Trial name
- NCT06526247
- Testing
- Strength at Home (SAH), Treatment as usual for IPV
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Boston University
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Tetris Intervention Following Subliminal Reactivation for Intrusive Memories
Intrusive memories of traumatic events are a core feature of Post-Traumatic Stress Disorder (PTSD) and can cause substantial distress and functional impairment.
- Trial name
- NCT07495917
- Testing
- Subliminal Reactivation Followed by Visuospatial Interference, Computer-based Visuospatial Task (Tetris)
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shaanxi Normal University
Insomnia, Depression - Major Depressive Disorder
Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI)
The goal of this pilot clinical trial is to evaluate the effectiveness and delivery method of a CBTI self-managed digital mobile application in service members. The main questions it aims to answer are: RQ1.
- Conditions
- Insomnia, Depression - Major Depressive Disorder, PTSD
- Trial name
- NCT07335276
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Volunteers
- 144 people
- Sponsor
- Madigan Army Medical Center
TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder
Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy
The purpose of this study is to evaluate how hyperbaric oxygen therapy (HBOT) may affect cognitive functioning, post-traumatic stress disorder (PTSD), depression, anxiety, and overall quality of life in veterans. 1.
- Conditions
- TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder, Post Concussive Syndrome
- Trial name
- NCT07214415
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Summit Hyperbarics and Wellness
Distal Radius Fractures, Rehabilitation
Evaluation of Limb Function and Perception in Rehabilitation After Traumatic Wrist Fracture Surgery
The goal of this observational study is to assess the functional and perceptual alterations of the affected limb during rehabilitation in adult orthopedic patients who underwent surgical treatment for distal radius fractures.
- Conditions
- Distal Radius Fractures, Rehabilitation, Body Perception
- Trial name
- NCT06866340
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Obsessive Compulsive Disorder (OCD), Comorbid Post-Traumatic Stress Disorder and OCD
ERP to Improve Functioning in Veterans With OCD
Obsessive compulsive disorder (OCD) is a debilitating psychiatric illness impacting work, social, and family functioning. Exposure and Response Prevention (ERP) is the sole evidence-based psychotherapy for OCD; however, no…
- Trial name
- NCT05240924
- Testing
- Exposure and Response Prevention, Stress Management Training
- Where
- 19 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis
Safety and Performance Assessment of the SYMBOL Range of Medical Devices in Patients Underlying Total Hip Arthroplasty
The purpose of this post-market clinical follow up study is to assess the safety and effectiveness of the SYMBOL range of medical devices.
- Conditions
- Degenerative Hip Joint Disease, Post-traumatic Osteoarthritis, Hip Arthritis, Femoral Neck Fractures
- Trial name
- NCT05227924
- Testing
- Total hip arthroplasty (primary or revision)
- Where
- 9 sites in France
- Volunteers
- 747 people
- Sponsor
- Dedienne Sante S.A.S.
Stress Disorders, Post-Traumatic; Mental Disorders
PTSD Treatment for Veterans With Serious Mental Illness to Improve Functional Outcomes
PTSD is common among Veterans with serious mental illness (SMI). Co-occurring PTSD and SMI lead to poorer mental health and physical functioning than either diagnosis alone.
- Trial name
- NCT05674617
- Testing
- Written Exposure Therapy, PTSD Education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- VA Office of Research and Development
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
PTSD
Facilitating Transition to Recommended PTSD Treatment
Cognitive processing therapy (CPT) and prolonged exposure therapy (PE) were widely disseminated as recommended posttraumatic stress disorder (PTSD) treatments.
- Trial name
- NCT05165940
- Testing
- Treatment As Usual, New Health Services Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC)
The KinematX Midcarpal Total Wrist Arthroplasty Registry
The goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the KinematX total wrist replacement study.
- Conditions
- Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS)
- Trial name
- NCT05719935
- Testing
- KinematX total wrist arthroplasty system
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Extremity Medical
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Posttraumatic Stress Disorder
Cognitive Training for Functioning in PTSD
The proposed study will test a novel, computerized treatment for posttraumatic stress disorder (PTSD) to determine if it helps Veterans functionally recover as measured by reduced cognitive disability and PTSD symptoms.
- Trial name
- NCT07693686
- Testing
- COGENT (Cognitive ENhancement Training)
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Improving Sleep in Veterans With the Polytrauma Clinical Triad
The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain.
- Conditions
- Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
- Trial name
- LIONv2 (NCT06477796)
- Testing
- Morning Bright Light Therapy, Negative Ion Generator
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Stress, Trauma
Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness
The purpose of this study is to investigate justice-involved Black/African American female adolescents' (JI BAFAs; N=35) self-reported outcomes: stress, posttraumatic stress disorder (PTSD), recidivism, etc., as well as their…
- Conditions
- Stress, Trauma, PTSD, HPA
- Trial name
- NCT06311188
- Testing
- ITR Healing intervention
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Stress Disorders, Post-Traumatic
Computational Assessment of GABA Receptor Modulation in PTSD
A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications.
- Trial name
- NCT06852469
- Testing
- Lorazepam 1 mg tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development