Clinical trials: Post-traumatic Stress Disorder
Posttraumatic Stress Disorder, Major Depressive Disorder
Predicting SSRI Efficacy in Veterans With PTSD
This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective…
- Trial name
- SSRI (NCT04183205)
- Testing
- LDAEP, sertraline
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Grief, Post Traumatic Stress Disorder
Building and Sustaining Interventions for Children: Task-sharing Mental Health Care in Low-resource Settings
The BASIC study will take place in Kanduyi/Bungoma South Sub-County, in western Kenya, and focuses on children orphaned by one or two parents.
- Conditions
- Grief, Post Traumatic Stress Disorder, Depression
- Trial name
- BASIC (NCT03243396)
- Testing
- Trauma-Focused Cognitive Behavioral Therapy
- Where
- Kenya
- Volunteers
- 956 people
- Sponsor
- Duke University
Stress Disorders, Posttraumatic, Tobacco Use Disorder
Nicotine Patch Pretreatment for Smoking Cessation in PTSD
This study seeks to evaluate the relationship between PTSD, abstinence, and factors associated with relapse in the context of a randomized, clinical smoking cessation trial.
- Trial name
- NCT00625131
- Testing
- Nicotine, Cognitive Behavioral Therapy for Smoking Cessation, Bupropion Sustained Release (SR)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Post-traumatic Stress Disorder (PTSD)
rTMS in the Treatment of PTSD
The purpose of this study is to assess the effects of repetitive transcranial magnetic stimulation (rTMS) in civilian patients with a confirmed diagnosis of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01806168
- Testing
- rTMS
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of British Columbia
Combat Disorders, Post-traumatic Stress Disorder
Treatment of Older Veterans With Chronic Posttraumatic Stress Disorder
This project represents the first randomized clinical trial of psychotherapy for older veterans with posttraumatic stress disorder (PTSD). It will compare relaxation training (RT) to prolonged exposure therapy (PE).
- Trial name
- NCT00539279
- Testing
- Prolonged Exposure Therapy (PE), Relaxation Training (RT)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- US Department of Veterans Affairs
Post-Traumatic Stress Disorders, Opiate Use Disorder
Optimal Treatment of Veterans With PTSD and Comorbid OUD
The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD).
- Trial name
- NCT03605342
- Testing
- Buprenorphine, Cognitive Processing Therapy (CPT), Individual Drug Counseling (IDC)
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Bright Light: An Adjunct Treatment for Combat Posttraumatic Stress Disorder (PTSD)
The investigators are testing novel treatments for combat PTSD: bright light exposure and negation ion exposure.
- Trial name
- NCT00701064
- Testing
- Bright Light Exposure, Negative Ion Generator
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
The goal of this clinical trial is to learn if MDMA in combination with therapy is safe and effective in people with chronic, treatment-resistant PTSD.
- Trial name
- NCT01793610
- Testing
- Comparator Dose (40mg) MDMA HCl, Active Dose 2 (100 mg) MDMA HCl, Active Dose 1 (125 mg) MDMA HCl
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Resilient Pharmaceuticals
PTSD
TMS for Veterans Attending a 2-week Intensive Outpatient Program for PTSD
The goal of this study is to determine whether complementing regular intensive PTSD treatment with intermittent theta burst stimulation (iTBS) applied to the right dorsolateral prefrontal cortex (DLPFC) can improve treatment…
- Trial name
- NCT06271733
- Testing
- TMS
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Rush University Medical Center
PTSD
Neural Circuits in Women With Abuse and Posttraumatic Stress Disorder
The purpose of this study was to assess the effects of the medication paroxetine on symptoms of posttraumatic stress disorder (PTSD) and the brain in women with a history of PTSD related to childhood abuse.
- Trial name
- NCT01681849
- Testing
- Paroxetine, Positron Emission Tomography (PET) Imaging
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Emory University
Post Traumatic Stress Disorders, Burns
Cranial Electrotherapy Stimulation in Burned Patients
To find out if Cranial Electrotherapy Stimulation is a useful treatment for people who have been burned and have Post Traumatic Stress Disorder. CES may be helpful in giving relief to some or all of those symptoms.
- Trial name
- CES (NCT00723008)
- Testing
- Alpha Stim 100 (Cranial Electrotherapy Stimulation)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
PTSD, Anxiety
EEG Biofeedback Therapy as an Adjunct Treatment for PTSD
The proposed study, "Placebo-controlled study of EEG biofeedback therapy as an adjunct treatment for PTSD, evaluating symptoms and EEG dynamics", will investigate the brain dynamics associated with PTSD symptom reduction…
- Conditions
- PTSD, Anxiety, Trauma, Sleep Disorders
- Trial name
- NCT01591408
- Testing
- EEG biofeedback
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- United States Naval Medical Center, San Diego
Posttraumatic Stress Disorder
Improving Psychosocial Functioning in Older Veterans With PTSD
The purpose of this project is to develop an intervention to improve psychosocial functioning and quality of life for older Veterans with partial or full PTSD.
- Trial name
- NCT02803125
- Testing
- Psychosocial intervention, Support group control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spouses, Military Personnel
Spouse READI (Resilience Education And Deployment Information) Post Deployment Telephone Support Groups
This 12-month study is for spouses or significant others of service members who have returned from Afghanistan or Iraq. This study will determine if participating in a telephone discussion group, offering education, skills…
- Conditions
- Spouses, Military Personnel, Coping Skills
- Trial name
- Spouse READI (NCT01121250)
- Testing
- Telephone Discussion Groups, Education sessions
- Where
- United States
- Volunteers
- 228 people
- Sponsor
- Memphis VA Medical Center
Alcohol Use Disorder, Post Traumatic Stress Disorder
Stress, Emotion Regulation, and Alcohol in Women Veterans
The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and…
- Trial name
- SERA (NCT04393623)
- Testing
- Cognitive Reappraisal, Psychoeducation
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Alcohol Abuse
Combined Treatment for Alcohol-Dependent Individuals With PTSD
This treatment intervention trial is designed for men and women with either alcohol misuse (e.g. hazardous or binge drinking) or alcohol use disorders (alcohol abuse or dependence) and comorbid PTSD.
- Conditions
- Stress Disorders, Post-Traumatic, Alcohol Abuse, Substance-Related Disorders
- Trial name
- NCT00262223
- Testing
- Seeking Safety, Sertraline
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- New York State Psychiatric Institute
Pain, Posttraumatic Stress Disorder
Integrated Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
The purpose of this study is to examine the efficacy of an integrated treatment for Veterans with comorbid chronic pain and posttraumatic stress disorder (PTSD).
- Trial name
- NCT00127413
- Testing
- Cognitive Behavioral Therapy - Pain, Cognitive Behavioral Therapy-Integrated, Cognitive Processing Therapy - PTSD
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- US Department of Veterans Affairs
Anxiety, PTSD
A Placebo-Controlled Study of Mirtazapine for PTSD
Objective: To study the efficacy and tolerability of mirtazapine (Remeron) in the treatment of PTSD. Research Design: This is an 8-week randomized, double-blind, placebo-controlled treatment trial of mirtazapine for the treatment…
- Trial name
- NCT00302107
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder, Posttraumatic Stress Disorder (PTSD)
Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
The purpose of this study is to evaluate whether the combination of prazosin and naltrexone will decrease alcohol cravings and drinking in individuals who have problems with alcohol and have used alcohol at risky levels compare…
- Trial name
- PaN (NCT02322047)
- Testing
- Prazosin, Naltrexone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Insomnia, Depression
Adjunctive Brief Behavioral Treatment of Insomnia (BBTI) for Sleep Intervention (SI)
There is a strong association between sleep disturbance and suicidal thoughts and behaviors. Sleep disturbance is also highly comorbid with other common conditions associated with suicide such as depression and posttraumatic…
- Conditions
- Insomnia, Depression, Posttraumatic Stress Disorder, Suicidal Ideation
- Trial name
- NCT02248675
- Testing
- CBT-I, TAU
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development