Clinical trials: PostPartum
Contraception
Early Postpartum Intrauterine Device (IUD) Placement
Women who have just given birth are at high risk for rapid repeat pregnancy, which can lead to negative consequences during the subsequent pregnancy.
- Trial name
- NCT01594476
- Testing
- Levonorgestrel IUS
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypertension, Pregnancy-Induced
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide
The main purpose of this study is to learn if incorporating a loop diuretic such as furosemide along with labetalol in the routine management of postpartum gestational hypertensive disorders could lower the need for additional…
- Trial name
- NCT04343235
- Testing
- furosemide, labetalol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wright State University
Healthy
The Safety and Efficacy of Recombinant Human Prolactin
Medications used to increase breast milk production increase prolactin secretion, the main hormone of lactation. There are no FDA approved medications used to improve breast feeding, but metoclopramide is used off-label and can…
- Trial name
- NCT00438490
- Testing
- Recombinant Human Prolactin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pre-Eclampsia, HELLP Syndrome
Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features
NSAIDs, specifically cyclo-oxygenase (COX) inhibitors, are known to increase blood pressure over time in non-pregnant adults, but the effect of COX-inhibitors on blood pressure in the setting of preeclampsia have not been well…
- Conditions
- Pre-Eclampsia, HELLP Syndrome, Eclampsia
- Trial name
- NCT02911701
- Testing
- Acetaminophen, Ibuprofen
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Pain, Postoperative, Depression, Postpartum
Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)
The purpose of this study is to identify a tolerable dose for postpartum ketamine infusion using a maximum tolerated dose (MTD) 3+3 design.
- Trial name
- NCT05907213
- Testing
- Ketamine (Ketalar) Dose Level 1, Ketamine (Ketalar) Dose Level 2, Ketamine (Ketalar) Dose Level 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Breastfeeding
Impact of a Smartphone Application on Postpartum Weight Loss and Breastfeeding Rates Among Low-income, Urban Women
Breastfed babies have significant health benefits extending beyond infancy, including lower rates of childhood obesity and infection.
- Trial name
- NCT03167073
- Testing
- BreastFeeding Friend (BFF), dummy app
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Postpartum Depression
Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression
This is a feasibility study of performing repeated EEG recordings and assessment of affective states during open-label administration of BRX to women with postpartum depression.
- Trial name
- BRX-PPD (NCT05543746)
- Testing
- Brexanolone
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Postpartum Depression
A Study to Evaluate Safety and Efficacy of SAGE-547 in Participants With Moderate Postpartum Depression (547-PPD-202C)
The purpose of this study was to determine if SAGE-547 Injection infused intravenously at up to 90 μg/kg/h for 60 hours reduces depressive symptoms in participants with moderate postpartum depression (PPD) compared to placebo…
- Trial name
- NCT02942017
- Testing
- SAGE-547 90 μg/kg/h
- Where
- 32 sites in United States
- Volunteers
- 108 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Sleep Disordered Breathing, Upper Airway Collapsibility
Incidence of Sleep-disordered Breathing and Upper Airway Collapsibility in Postpartum Patients and Its Intervention
The investigators hypothesized that sleeping in a 45 degrees elevated body position decreases the likelihood of upper airway vulnerability to collapse early after delivery.
- Conditions
- Sleep Disordered Breathing, Upper Airway Collapsibility, Upper Airway Obstruction
- Trial name
- NCT01719224
- Testing
- elevated body position, supine body position
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital