Clinical trials: Postconcussion Syndrome
Post-Concussion Syndrome
Post-concussion Syndrome and Chiropractic
This proof-of-concept trial will explore the effects of manual chiropractic adjustments on nervous system function in individuals with post-concussion syndrome.
- Trial name
- PCS (NCT06151184)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Life University
Post-Concussion Syndrome, Post-Traumatic Headache
Digital Solutions for Concussion
The objective of this study is to develop new digital solutions for patients with prolonged postconcussion symptoms, and investigate its usability, feasibility, and safety.
- Trial name
- DiSCo (NCT05635656)
- Testing
- Digital symptom mapping and biofeedback treatment
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- St. Olavs Hospital
Traumatic Brain Injury, Post-traumatic Stress Disorder
Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder
This is an observational research study whose purposes are to see: 1. if 40 Hyperbaric Oxygen Therapy sessions at 1.5 atmospheres (HBOT 1.5) or more (60, or 80 HBOT's) help, worsen, or have no effect on subjects with chronic…
- Trial name
- NBIRR-1 (NCT01105962)
- Where
- 10 sites in United States
- Volunteers
- 133 people
- Sponsor
- International Hyperbaric Medical Foundation
Chronic Traumatic Encephalopathy
Post-Concussion Syndrome in Professional Athletes: A Multidisciplinary Study
to examine the relationship between repeated concussions and late decline of brain function. In addition, all participants agreeing to participate in the study will be asked to will their brains to The Krembil Neuroscience Centre…
- Trial name
- NCT03218332
- Testing
- Biomarkers for detecting possible CTE invivo
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Post Concussive Symptoms
Chasing Biomarkers in Post-concussion Syndrome
The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive…
- Trial name
- NCT05812742
- Testing
- Early intervention programme, Enhanced usual care
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hyperbaric Oxygen Therapy, Traumatic Brain Injury
Hyperbaric Oxygen Therapy Effect on Post Concussion Syndrome in Children
Due its high incidence, mTBI and its consequences of PPCS are a major public health issue. There is no consensus regarding the treatment of PPCS in pediatrics.
- Conditions
- Hyperbaric Oxygen Therapy, Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- TBIPED (NCT03339037)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Assaf-Harofeh Medical Center
Post-Concussion Syndrome
The Effectiveness of Biofeedback for Individuals With Long-term Post-concussive Symptoms
Most concussions resolve within 7-10 days, but approximately 40% of individuals do not fully recover and suffer from persistent post-concussive symptoms.
- Trial name
- NCT03338036
- Testing
- Heart Rate Variability Biofeedback, Neurofeedback
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Western University, Canada
Mild Traumatic Brain Injury, Post-Concussive Symptoms
Consistency of Automated Neuropsychological Assessment Metrics (ANAM) Performance in Those With Deployment Acquired Mild Traumatic Brain Injury (TBI)
The purpose of this project is to explore the degree to which performance consistency on neuropsychological measures varies in a sample of Operation Iraqi Freedom (OIF)/Operation Enduring Freedom (OEF) Veterans with a history of…
- Trial name
- ANAM (NCT01334528)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Posttraumatic Headache, Combat Disorders
Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
The purpose of this study is to determine if prazosin is more effective than placebo in decreasing frequency, severity, disability, and other negative effects of headaches related to mild traumatic brain injury in Service Members…
- Conditions
- Posttraumatic Headache, Combat Disorders, Post Concussion Syndrome, Headache
- Trial name
- NCT02266329
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- VA Office of Research and Development
Concussions, Post-Concussive Symptoms
Pediatric Concussion Assessment of Rest and Exertion
The goal of this study is to investigate when is the best time to resume physical activity following a head injury. Two treatment plans will be studied; the first treatment plan consists of gradually reintroducing physical…
- Trial name
- PedCARE (NCT02893969)
- Testing
- Physical Activity, Rest
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Children's Hospital of Eastern Ontario
Post-Concussion Syndrome, Headache
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in…
- Trial name
- NCT04685772
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwell Health
TBI (Traumatic Brain Injury), Post Concussion Syndrome
Hyperbaric Oxygen Therapy (HBOT) in Chronic Traumatic Brain Injury (TBI)/Post Concussion Syndrome (PCS) and TBI/Post-Traumatic Stress Disorder (PTSD)
This is a pilot trial to see if one or two 40 treatment courses of low pressure hyperbaric oxygen therapy can improve cognition and brain imaging in subjects with either chronic mild-moderate traumatic brain injury (TBI), also…
- Conditions
- TBI (Traumatic Brain Injury), Post Concussion Syndrome, Post Traumatic Stress Disorder, Chronic Post Traumatic Stress Disorder
- Trial name
- NCT00760734
- Testing
- Low pressure hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Paul G. Harch, M.D.
Commotio Cerebri, Mild Traumatic Brain Injury
Get Going After concussioN 2.0
The study tests the promising results of a previous study (GAIN 1.0) in a larger RCT (GAIN 2.0) which takes place in the municipalities of Central Denmark Region where citizens live their daily lives and whose health- and social…
- Trial name
- GAIN2 (NCT04798885)
- Testing
- GAIN 2.0
- Where
- Denmark
- Volunteers
- 310 people
- Sponsor
- University of Aarhus
Brain Concussion, Post-Concussion Syndrome
Early Intervention Programme for Young Patients (Aged 15 - 30 Years) With Symptoms Following Concussion.
Background: Five - 15 % of patients with concussion continue to experience impairing physical, cognitive and emotional symptoms longer than 3 months post-injury.
- Trial name
- NCT02337101
- Testing
- Enhanced Usual Care (EUC), EUC + Early intervention programme
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Post-Concussion Syndrome
Cerebellar TDCS for SRPCS Treatment
This study is investigating the immediate and long-term effects of bilateral cerebellar transcranial direct current stimulation on cognition, balance, and symptom severity in people with sports-related post-concussion syndrome.
- Trial name
- NCT04760899
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Post-Concussion Syndrome
Accelerated, Theta-burst Stimulation for the Treatment of Post-concussion Syndrome - Open-label Pilot Study
The current study aims to better understand the efficacy of intermittent theta-burst stimulation (iTBS) treatment in patients diagnosed with post-concussion syndrome (PCS) and to explore changes in brain networks after undergoing…
- Trial name
- NCT06398665
- Testing
- Intermittent Theta-Burst Stimulation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Brain Injury, Chronic
Hyperbaric Oxygen for Traumatic and Non-traumatic Brain Injury
The purpose of this study is to examine whether 40 hyperbaric oxygen sessions has effect on long-term symptoms after brain injury.
- Trial name
- HYBOBI2 (NCT01986205)
- Testing
- Hyperbaric Oxygen, Minimal pressure air
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Lindell Weaver
Congenital Heart Defect, Chronic Pain
Impacting Children's Physical and Mental Health Through Kinesiology Support in Clinical Care
Over the past four decades, it has become clear that childhood physical activity carries with it a myriad of beneficial effects.
- Conditions
- Congenital Heart Defect, Chronic Pain, Concussion Post Syndrome, Cerebral Palsy
- Trial name
- NCT04106154
- Testing
- Kinesiology Support
- Where
- Canada
- Volunteers
- 111 people
- Sponsor
- Children's Hospital of Eastern Ontario
Concussion, Brain
A Wrist-Worn Nerve Stimulator for Remediating Persistent Post-Concussive Symptoms in Adolescents
The goal of this study is to test a wearable nerve stimulator in adolescents with persistent post-concussive symptoms. The main questions it aims to answer is whether the device will reduce clinical symptom burden, reduce…
- Trial name
- NCT05685121
- Testing
- Apollo Neuro
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of South Carolina
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University