Clinical trials: Postoperative Acute Myocardial Infarction
Myocardial Infarction
Etanercept Treating Patient With Acute ST Segment Elevated Myocardial Infarction
Our aim is to observe whether anti-TNF-alpha regimen will effect serum adiponectin concentration after myocardial infarction/reperfusion and also beneficial for the patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- NCT01372930
- Testing
- Etanercept, saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI)
Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients
The goal of this clinical trial is to learn if giving the drug empagliflozin before versus after a heart procedure called primary PCI (percutaneous coronary intervention) affects how much heart muscle is damaged during a heart…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI), Coronary Artery Disease
- Trial name
- TEMPO-STEMI (NCT07749014)
- Testing
- empagliflozin
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- Rehman Medical Institute - RMI
Myocardial Infarction, Reperfusion Injury
Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries.
- Trial name
- NCT00265239
- Testing
- edaravone
- Where
- Japan
- Volunteers
- 104 people
- Sponsor
- Kumamoto University
Myocardial Reperfusion Injury, Myocardial Ischemia
Remote Postconditioning in Patients With Acute Myocardial Infarction Treated by Primary Percutaneous Coronary Intervention (PCI)
Background: Experimental studies suggest that remote limb ischaemic postconditioning (RemPostCon) can reduce infarct size in pigs.
- Conditions
- Myocardial Reperfusion Injury, Myocardial Ischemia, Myocardial Infarction
- Trial name
- RemPostCon (NCT00865722)
- Testing
- Remote Postconditioning
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Acute Myocardial Infarction
Sweat Analysis as Prognosticator After Heart Attack
This study characterizes non-invasive body inflammation response in sweat and blood of patients suffering from acute myocardial infarction and explores the potential of non-invasive sweat analysis a an innovative approach for…
- Trial name
- SWEATHEART (NCT05843006)
- Testing
- Examination and analysis of sweat and blood samples at baseline and at follow up, Examination and analysis of sweat and blood samples at baseline
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Örebro County
Coronary Artery Disease, Acute Coronary Syndrome
Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome
The present study seeks to evaluate the effectiveness of the use of perioperative colchicine with regard to operative complications, in patients with acute coronary syndrome and indication for cardiac post-surgical…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Coronary Artery Bypass, Myocardial Reperfusion
- Trial name
- COCAR (NCT05726019)
- Testing
- Colchicine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Acute Myocardial Infarction, Ischemia-reperfusion Injury
Combined Antioxidant Therapy Against Myocardial Reperfusion Injury. Phase I Study.
Background: Acute myocardial infarction (AMI) has remained a leading cause of mortality and disability worldwide. Although percutaneous coronary angioplasty (PCA) is the best treatment for these patients, paradoxically this…
- Conditions
- Acute Myocardial Infarction, Ischemia-reperfusion Injury, Reperfusion Injury, Myocardial, Reperfusion Arrhythmias
- Trial name
- NCT05215743
- Testing
- Antioxidant therapy, NaCl 0.9%
- Where
- Chile
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Chile
Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction
Novel Imaging Biomarkers for Mechanical Complications in Acute Myocardial Infarction
Hemorrhagic Myocardial infarctions are at high risk for mechanical complications including cardiac rupture. Prediction of vulnerable myocardial segments is an important step for the stratification of hemorrhagic MI patients.
- Conditions
- Acute Myocardial Infarction, Hemorrhagic Myocardial Infarction, Myocardial Stunning, Myocardial Hemorrhage
- Trial name
- MIRON-RUPTURE (NCT06450912)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rohan Dharmakumar
Ischemia-reperfusion Injury, No-reflow
Intracoronary Administration of Glucocorticoids as a Treatment Method for No-Glucocorticoid Treatment for No-Reflow in STEMI
The goal of this clinical trial is to improve reperfusion therapy in STEMI patients with no-reflow phenomenon. Based on literature review and pathological studies, the investigators believe that myocardial ischemia-reperfusion…
- Trial name
- GCT-NR-STEMI (NCT06552442)
- Testing
- Methylprednisolone
- Where
- Ukraine
- Volunteers
- 10 people
- Sponsor
- Amosov National Institute of Cardiovascular Surgery
Acute Myocardial Infarction, Myocardial Reperfusion Injury
Optimized Cardioprotection Therapy in Obese Subjects With AMI
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With acute myocardial infarction (AMI) Who Have Undergone Percutaneous Coronary Intervention (PCI).
- Conditions
- Acute Myocardial Infarction, Myocardial Reperfusion Injury, Obesity, Adiposis; Heart
- Trial name
- NCT04570514
- Testing
- PCI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Myocardial Reperfusion Injury
Post Cond No Reflow
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of…
- Trial name
- NCT01208727
- Testing
- postconditioning
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Hospices Civils de Lyon
Acute Myocardial Infarction
Sodium Nitrite in Acute Myocardial Infarction
The purpose of this study is to determine whether the intravenous infusion of sodium nitrite safely prevents ischemia-reperfusion injury in subjects with acute myocardial infarction resulting in improved left ventricular function.
- Trial name
- NCT00924118
- Testing
- Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Myocardial Reperfusion Injury
POSTconditioning During Coronary Angioplasty in Acute Myocardial Infarction Study
The POST-conditioning during coronary angioplasty in Acute Myocardial Infarction (POST-AMI) trial will evaluate the usefulness of postconditioning in limiting infarct size and microvascular damage during the early and late phases…
- Trial name
- POST-AMI (NCT01004289)
- Testing
- Postconditioning, Primary angioplasty and stenting without additional intervention
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- University of Padova
ST Elevation Acute Myocardial Infarction
Cyclosporine and Prognosis in Acute Myocardial Infarction (MI) Patients
Infarct size is a major determinant of prognosis after Acute Myocardial Infarction (AMI). The investigators recently reported that cyclosporine A, when administered immediately prior to percutaneous coronary intervention (PCI)…
- Trial name
- CIRCUS (NCT01502774)
- Testing
- Injection of Cyclosporin, Echocardiography
- Where
- 45 sites in Belgium, France and 1 more
- Volunteers
- 970 people
- Sponsor
- Hospices Civils de Lyon
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Acute Coronary Syndromes, Acute Myocardial Infarction
Effect of Adjunctive Intracoronary Streptokinase on Late Term Left Ventricular Infarct Size and Volumes in Patients With Acute Myocardial Infarction
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide limitation infarct size and improvement in…
- Conditions
- Acute Coronary Syndromes, Acute Myocardial Infarction, Reperfusion Injury
- Trial name
- NCT00627809
- Testing
- Streptokinase, primary percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction, Reperfusion Injury
Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction
Despite advances in the treatment of heart attacks the complications and death rates from failure of the heart to pump properly after treatment remain high.
- Conditions
- Myocardial Infarction, Reperfusion Injury, Myocardial Ischemia, Cardiovascular Diseases
- Trial name
- NITRITE-AMI (NCT01584453)
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Barts & The London NHS Trust