Clinical trials: Postoperative Acute Pain
Hallux Valgus
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy Compared With Placebo
The purpose of this study is to evaluate the analgesic efficacy and safety of tapentadol immediate-release (IR [CG5503]) for use in the relief of moderate to severe acute pain, compared with placebo, in adult Taiwanese patients…
- Trial name
- NCT01813890
- Testing
- Tapentadol IR 50 mg, Tapentadol IR 75 mg
- Where
- 3 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Janssen-Cilag International NV
Pain, Postoperative Pain
A Randomized, Double-Blind, Parallel-Arm, Placebo and Active Controlled Dose-Ranging Study of the Efficacy and Safety of Multiple Doses of Tapentadol IR for Postoperative Pain Following Bunionectomy Surgery
This study was to evaluate the efficacy and safety of dosing regimens of tapentadol HCl immediate release capsules for the treatment of postoperative pain over a period of 12 hours on the first day following a bunionectomy in men…
- Trial name
- NCT00806247
- Testing
- tapentadol HCl
- Volunteers
- 480 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Postoperative Pain
Maxigesic® IV Phase 3 Exposure Study
The study aims to determine the tolerability of repeated doses of Maxigesic® IV over an extended period of exposure.
- Trial name
- NCT04005755
- Testing
- Maxigesic® IV
- Where
- 4 sites in United States, New Zealand
- Volunteers
- 232 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Bunionectomy, Pain
A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy
The main objective of this trial is to demonstrate the efficacy and safety of multiple-dose application of oral application of CG5503 IR 75mg compared to placebo and to assess safety and tolerability of CG5503 IR 75mg in subjects…
- Conditions
- Bunionectomy, Pain, Postoperative Pain, Acute Pain
- Trial name
- NCT00609466
- Testing
- CG5503 IR, Morphine
- Where
- 6 sites in United States
- Volunteers
- 291 people
- Sponsor
- Grünenthal GmbH
Bunionectomy, Orthopedic Surgery
Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy
To determine whether a single dose of intravenous lornoxicam is superior to intravenous placebo for management of post-operative pain in patients who have surgical removal of a bunion on the lower extremity.
- Trial name
- NCT00293631
- Testing
- Lornoxicam 8 mg, Lornoxicam 16 mg, Ketorolac 30 mg
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- POZEN
Acute Pain, Post Operative Pain
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Bunionectomy
MR-107A-02 is being studied to investigate its efficacy and safety for treatment of acute pain after bunionectomy.
- Conditions
- Acute Pain, Post Operative Pain, Pain
- Trial name
- NCT06215820
- Testing
- MR-107A-02, Tramadol, Bunionectomy
- Where
- 15 sites in United States
- Volunteers
- 410 people
- Sponsor
- Viatris Specialty LLC
Pain, Postoperative
Study of Diclofenac Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age
The purposes of this study are to evaluate the safety and tolerability and to model the single-dose pharmacokinetic profile of diclofenac capsules low dose and high dose in children ages 6 to <17 years experiencing mild to…
- Trial name
- NCT02424578
- Testing
- Diclofenac Capsules low dose, Diclofenac Capsules high dose
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Pain, Postoperative, Pediatrics
An Evaluation of Safety of the Fentanyl Transdermal System for Management of Acute Post-Operative Pain in Pediatric Patients
The purpose of this study is to evaluate the safety and clinical utility of fentanyl HCl 40 mcg system for the management of postoperative pain in pediatric inpatients.
- Trial name
- NCT00666393
- Testing
- fentanyl iontophoretic transdermal system (40mcg)
- Sponsor
- Alza Corporation, DE, USA
Pain
A Study of TRV130 for the Treatment of Pain After Abdominoplasty
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain following abdominoplasty.
- Trial name
- NCT02335294
- Testing
- TRV130, Morphine
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Trevena Inc.
Moderate to Severe Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute moderate to severe…
- Trial name
- NCT01016808
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 5 sites in United States
- Volunteers
- 522 people
- Sponsor
- QRxPharma Inc.
Other Acute Postoperative Pain
Study of Diclofenac Capsules to Treat Pain Following Bunionectomy
The purpose of this study is to determine whether Diclofenac [Test] Capsules are safe and effective for the treatment of bunionectomy pain.
- Trial name
- NCT01462435
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib
- Where
- 4 sites in United States
- Volunteers
- 428 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Other Acute Postoperative Pain
Oxycodone Hydrochloride Injection in the Postoperative Pain Relieving Treatment
To determine the efficacy and safety of oxycodone i.v. patient-controlled analgesia (PCA) in the pain relieving treatment during 48h postoperative period, by comparing with morphine i.v. PCA.
- Trial name
- NCT01304134
- Testing
- Oxycodone, Morphine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Mundipharma (China) Pharmaceutical Co. Ltd
Acute Post Operative Pain, Third Molar Extraction Surgery
A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction
The study will test the investigational product gel against placebo (which contains no active ingredient) to determine if it is safe after wisdom tooth extraction. The main questions the study will answer are: 1.
- Trial name
- NCT06864884
- Testing
- ARC-001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arcato Laboratories, Inc.
Acute Postoperative Pain, Tramadol Adverse Effect
Prospective Pharmacogenetic Cohort Study of CYP2D6 Metabolizer Phenotype, Analgesic Failure, and Adverse Effects in Postoperative Patients Receiving Tramadol by Elastomeric Infusion Pump
This prospective pharmacogenetic cohort will enroll postoperative patients receiving a standardized tramadol-containing elastomeric analgesia pump.
- Conditions
- Acute Postoperative Pain, Tramadol Adverse Effect, Pharmacogenetic Variation
- Trial name
- NCT07810816
- Testing
- Standardized Tramadol Elastomeric Analgesia Pump, CYP2D6 Genotyping and Metabolizer Phenotype Assignment
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Research Inc
Postoperative Pain
Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery
This study will compare repeated intermittent IV dosing of diclofenac in patient with moderate to severe post-surgical pain from elective orthopedic surgery.
- Trial name
- NCT00507026
- Testing
- IV Diclofenac, IV ketorolac
- Where
- 8 sites in United States
- Volunteers
- 277 people
- Sponsor
- Pfizer
Local Analgesia Via Infiltration
A Study of Bupivacaine Liposome Injection in Local Analgesia of Pediatric Patients
The study is being conducted to evaluate the safety and efficacy of bupivacaine liposome injection for local infiltration analgesia in pediatric orthopedic surgery in the real world.
- Trial name
- NCT06344091
- Testing
- Bupivacaine Liposome Injection
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Acute, Post-operative Pain
Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427
This randomized, double-blind, placebo controlled, study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of ST-2427.
- Trial name
- NCT04475198
- Testing
- ST-2427
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SiteOne Therapeutics, Inc.
Acute Moderate-to-severe Pain
A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain
This is a multicenter, open-label study in patients 40 years and older who are undergoing a surgical procedure. Patients may receive one dose of ST 30 mcg as needed for pain management, but no more frequently than every 60…
- Trial name
- NCT02662556
- Testing
- sufentanil sublingual tablet 30 mcg
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Talphera, Inc
Pain, Postoperative
Study of Indomethacin Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age
The purposes of this study are to evaluate the safety and tolerability and to model the single-dose pharmacokinetic profile of indomethacin capsules low dose and high dose in children ages 6 to <17 years experiencing mild to…
- Trial name
- NCT02633969
- Testing
- Indomethacin Capsules low dose, Indomethacin Capsules high dose
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company