Clinical trials: Postoperative Cardiac Surgery
Congenital Heart Disease, Postoperative Care
Empowering Families in Pediatric Cardiovascular Surgery: A RAM-Based Approach
The purpose of this clinical trial is to learn about the effects of a nursing support program designed for families of children aged 1 to 3 years who have undergone heart surgery.
- Conditions
- Congenital Heart Disease, Postoperative Care, Child Development, Roy Adaptation Model-based Nursing Empowerment Program
- Trial name
- NCT07575451
- Testing
- RAM-based Nursing Empowerment Program, Routine Care and Educational Booklet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Aortic Valve Stenosis, Regurgitation, Aortic
Comparison of the Balloon-Expandable Edwards Valve and Self-Expandable CoreValve Evolut R or Evolut PRO System for the Treatment of Small, Severely Dysfunctional Surgical Aortic Bioprotheses. The 'LYTEN' Trial
The treatment with transcatheter aortic valve implantation (TAVI) of patients with small (≤23mm) surgical bioprostheses remains a challenge due to the increased transvalvular residual gradients and high rates of severe…
- Conditions
- Aortic Valve Stenosis, Regurgitation, Aortic, Prosthesis Failure
- Trial name
- NCT03520101
- Testing
- TAVI_ViV procedure with Edwards valve, TAVI_ViV procedure with CoreValve system
- Where
- Canada
- Volunteers
- 102 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Cognitive Disorders, Delirium
The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia as well as as an analgesic. It has been shown to have anti-inflammatory properties which may decrease post-operative complications…
- Conditions
- Cognitive Disorders, Delirium, Acute Kidney Injury
- Trial name
- NCT02554253
- Testing
- Ketamine, Propofol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
Postoperative Delirium
Predictors for Postoperative Delirium After Cardiac Surgery in Adults: a One-year, Single Center, Observational Cohort Study
The Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) describes delirium as a "disturbance in attention (i.e., reduced ability to direct, focus, sustain, and shift attention) and awareness (reduced…
- Trial name
- PODCAS (NCT02613845)
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 656 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation New Onset
Silymarin for the Prevention of Atrial Fibrillation After Cardiac Surgery
The study is a prospective, randomized, controlled trial to assess the effects of silymarin on the occurrence of postoperative atrial fibrillation after coronary artery bypass graft surgery.
- Trial name
- NCT06114719
- Testing
- Silymarin
- Where
- Serbia
- Volunteers
- 160 people
- Sponsor
- University of Novi Sad
Anesthesia, Hemodynamic Instability
Anesthetic Guidance of Depth of Anesthesia and Indirect Cardiac Output Monitoring in Thoracic Surgery
Patients undergoing thoracotomy in thoracic surgery are prone to have complications of delayed recovery from general anesthesia and perioperative instable hemodynamics due to the relatively invasive procedures and patient's…
- Conditions
- Anesthesia, Hemodynamic Instability, Postoperative Respiratory Complication
- Trial name
- NCT04414228
- Testing
- M-Entropy guidance of anesthesia depth, ProAQT in guiding goal-directed hemodynamic therapy
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Postoperative Mechanical Ventilation Time
Study on the Effect of Target-controlled Infusion for General Anesthesia in Cardiac Surgery
The purpose of the study was to evaluate whether individualized general anesthesia with target-controlled infusion could help patients wake up early for extubation and reduce the incidence of postoperative complications, and to…
- Trial name
- NCT06012955
- Testing
- Target-controlled infusion (TCI) systems
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Heart; Dysfunction Postoperative, Cardiac Surgery, C.Surgical Procedure; Cardiac
Goal Directed Therapy Aiming to Optimise Oxygen Central Venous Saturation in Children Undergoing Cardiac Surgery
The purpose of this study is evaluate goal-directed therapy with continuous central venous saturation compared to standard therapy in children undergoing cardiac surgery.
- Trial name
- NCT03469440
- Testing
- Continuous central venous oxygenation monitoring, Standard protocol
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Instituto do Coracao
Transversus Thoracic Plane Block, Cardiac Surgery
Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery
The goal of this clinical trial is to learn if perioperative Transversus Thoracic Plane Block (TTPB) decrease perioperative pain after cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Transversus Thoracic Plane Block, Cardiac Surgery, Post Operative Pain
- Trial name
- NCT06546722
- Testing
- Transversus Thoracic Plane Block
- Where
- Lebanon
- Volunteers
- 150 people
- Sponsor
- Saint-Joseph University
Heart; Dysfunction Postoperative, Cardiac Surgery, Myocardial Infarction
High-sensitivity Troponin in Cardiac Surgery
Among patients undergoing heart surgery, a measurable degree of heart muscle tissue injury is expected. The level of injury can be shown by measuring the blood levels of specific molecules called cardiac biomarkers.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Myocardial Infarction, Myocardial Injury
- Trial name
- NCT01913873
- Testing
- serum concentration changes cardiac biomarkers
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Onze Lieve Vrouw Hospital
Post-operative Delirium
Interest in Combining Intraoperative ElectroEncephaloGram (EEG) With Assessment of Frailty to Predict Postoperative Delirium in Patients Aged >75 Years Undergoing Major Non-cardiac Surgery
Post-operative delirium (POD) is known to be independently associated with pre-operative frailty, pre-operative cognitive status and per-operative ElectroEncephaloGram (EEG).
- Trial name
- NCT06510140
- Testing
- Detection of the Post-operative delirium (POD)
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation, Surgery--Complications
Novel Methods for Characterizing Patients With Post-operative Atrial Fibrillation Secondary to Abdominal Surgery
Purpose The primary purpose of the current project is to characterize unselected patients undergoing surgery developing post-operative atrial fibrillation (POAF), ultimately leading to a new risk-stratification model.
- Trial name
- NCT04090918
- Testing
- Cardiac examination programme 3 months after abdominal surgery
- Where
- Denmark
- Sponsor
- Frederiksberg University Hospital
Cerebral Desaturation, Surgery
Cerebral Oximetry to Reduce Organ Dysfunction After Non-cardiac Surgery
Number of elderly patients requiring general anesthesia for major surgical procedures is increasing dramatically. It is estimated that 20% of these patients will develop major complications after surgery.
- Trial name
- NCT03861026
- Testing
- Bilateral NIRS (Masimo, O3TM Regional Oximetry)
- Where
- 2 sites in Canada
- Volunteers
- 101 people
- Sponsor
- University Health Network, Toronto
Hypofibrinogenemia, Surgical Blood Loss
Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness
Fibrinogen concentrate is produced by different manufacturers using different purification technologies. The products available in Italy are three: RiaSTAP (CSL Behring), FIBRYGA (Octapharma), and FibCLOT (LFB).
- Conditions
- Hypofibrinogenemia, Surgical Blood Loss, Bleeding, Cardiac Disease
- Trial name
- EDIPORE (NCT05780125)
- Testing
- FibCLOT, RiaSTAP
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Acute Respiratory Infection, Sepsis
Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients
Capnodynamic monitoring has the potential to offer continuous and non-invasive measurements of heart and lung function in patients requiring ventilation in an intensive care setting.
- Conditions
- Acute Respiratory Infection, Sepsis, Postoperative Respiratory Distress
- Trial name
- PROFICIENT (NCT05082168)
- Testing
- Capnodynamic monitoring
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- South West Sydney Local Health District
Postoperative Delirium, Heart Valve Diseases
Transcranial Doppler and Artificial Intelligence Prediction of Postoperative Delirium in Heart Valve Surgery
Postoperative delirium is a frequent complication after cardiac surgery. This prospective observational study will evaluate whether cerebral blood flow velocity measured by transcranial Doppler before and during elective heart…
- Trial name
- NCT07858578
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Osman Sila Aydin
Heart Diseases, Heart Valve Diseases
To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications
The objective of this study was to evaluate the effect of esketamine on intraoperative hemodynamics in patients with heart valve replacement and to mitigate postoperative pulmonary complications
- Trial name
- NCT06467513
- Testing
- Esketamine hydrochloride injection
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Zhang XIao Mei
Cardiac Surgery, Coronary Artery Bypass Grafting
Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery
Respiratory dysfunction following cardiac surgery is well documented and due in part to the location of the incision and nature of the surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Chronic Obstructive Pulmonary Disease (COPD), Older Adults
- Trial name
- NCT02732574
- Testing
- Oscilatory Positive Expiratory Pressure (OPEP) device
- Where
- Canada
- Volunteers
- 162 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Postoperative Cognitive Decline, Postoperative Delirium
Increasing Preoperative Cognitive Reserve to Prevent Postoperative Cognitive Dysfunction in Cardiac Surgical Patients
Postoperative delirium (POD) and postoperative cognitive decline (POCD) can be observed after cardiosurgical interventions. Taken together, these postoperative neurocognitive dysfunctions contribute to increased morbidity and…
- Conditions
- Postoperative Cognitive Decline, Postoperative Delirium, Postoperative Cognitive Dysfunction
- Trial name
- INCORE (NCT04493996)
- Testing
- Cognitive training
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heart and Brain Research Group, Germany
Postoperative Cognitive Dysfunction
Feasibility and Acceptability of Home-based Computerised Cognitive Training After Cardiac Surgery
The aims of this study are to (1) evaluate the feasibility and acceptability of a home-based computerised cognitive training programme in the postoperative cardiac surgical population, and (2) estimate measures of precision about…
- Trial name
- FACCT (NCT05298540)
- Testing
- Home-based computerised cognitive training with BrainHQ
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Barts & The London NHS Trust