Clinical trials: Postoperative Cardiovascular Complication
Cardiac Disease, Analgesia
Parasternal Block for Cardiac Surgery
This study examine the effect of Parasternal Intercostal Nerve Blocks with local anesthetic on pain control in patients undergoing non-emergent cardiac surgery in a prospective controlled trial.
- Conditions
- Cardiac Disease, Analgesia, Acute Pain, Postoperative Pain
- Trial name
- Parasternal (NCT04319588)
- Testing
- Parasternal Block+ Infiltration with local anesthetic of access to thoracic drainage, Infiltration with local anesthetic of access to thoracic drainage
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Campus Bio-Medico University
Myocardial Reperfusion Injury, Cardiac Output, Low
Metabolic Support With Perhexiline to Protect Myocardium Undergoing Coronary Artery Surgery
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care.
- Trial name
- CASPER (NCT00845364)
- Testing
- Perhexiline
- Where
- 2 sites in United Kingdom
- Volunteers
- 290 people
- Sponsor
- University Hospital Birmingham
Surgical Blood Loss, Postoperative Blood Loss
Study of Fibrinogen Concentrate (Human) (FCH) to Control Bleeding During Complex Cardiovascular Surgery
The purpose of this study is to demonstrate that Fibrinogen Concentrate (Human)(FCH) can reduce the amount of donor blood products needed during complex cardiovascular surgery, and that it is safe and well tolerated.
- Trial name
- REPLACE (NCT01475669)
- Testing
- Fibrinogen Concentrate (Human) (FCH)
- Where
- 35 sites in Austria, Brazil and 9 more
- Volunteers
- 152 people
- Sponsor
- CSL Behring
Disorder Related to Lung Transplantation, Brain Death
Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation
The recent introduction of ex-vivo lung perfusion (EVLP) as a tool to evaluate and recondition lungs from marginal donors has opened a new era in the field of lung transplantation.
- Conditions
- Disorder Related to Lung Transplantation, Brain Death, Graft Failure, Primary Graft Dysfunction
- Trial name
- EVLP_MI (NCT01967953)
- Testing
- EVLP Group
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- Policlinico Hospital
Delirium - Postoperative, Sleep Problems
Preoperative Sleep Intervention on Postoperative Delirium in School-aged Children Undergoing Congenital Heart Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in sleep-disordered…
- Conditions
- Delirium - Postoperative, Sleep Problems, Congenital Heart Disease (CHD)
- Trial name
- NCT06879431
- Testing
- cognitive-behavioral intervention
- Where
- China
- Volunteers
- 544 people
- Sponsor
- Yan Fuxia
Acute Kidney Injury
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
- Trial name
- NCT01920126
- Testing
- sodium bicarbonate, Saline
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Hepatectomy, Reperfusion Injury
N-acetylcysteine to Reduce Ischemia/Reperfusion Injury in Liver Resection
Study hypothesis: N-acetylcysteine (NAC) can reduce ischemia/reperfusion injury in liver resection performed under ischemic preconditioning and intermittent portal triad clamping.
- Trial name
- NCT01223326
- Testing
- Acetylcysteine (NAC), Saline
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cardiovascular Diseases, Postoperative Complications
Effects of Cerebral Oxygen Saturation on Neuropsychological Outcomes
The purpose of this study is to evaluate the effects of maintaining adequate cerebral oxygen saturation (over 40%) on patients undergoing cardiac surgery.
- Trial name
- NCT00151307
- Testing
- INVOS cerebral oximeter
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Aortic Aneurysm
Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair
The durability of endovascular aneurysm repair (EVAR) has been limited by development of endoleaks which may be secondary to progressive aortic degeneration by matrix metalloproteases (MMP).
- Trial name
- NCT00126204
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Foundation for Barnes-Jewish Hospital
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Diabetes Mellitus, Diabetic Retinopathy
Intravitreal Long Acting Gas in the Prevention of Early Postoperative Vitreous Hemorrhage in Diabetic Vitrectomy
Recurrent vitreous hemorrhage after vitrectomy for complications of diabetic retinopathy is a common occurrence. The hemorrhage may appear within the first few weeks after surgery or months later.
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Vitreous Hemorrhage
- Trial name
- NCT00155454
- Testing
- Intravitreal long acting gas (10% C3F8)
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- National Taiwan University Hospital
Ischemia Reperfusion Injury
Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.
Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult.
- Trial name
- NCT03772054
- Testing
- Sevoflurane, Propofol
- Where
- Chile
- Volunteers
- 16 people
- Sponsor
- University of Chile
Vascular Access Complication, Device Related Infection
Novel Antimicrobial Dressing in Peripheral Intravenous Catheters (PIVCs)
The goal of this clinical trial is to compare a chlorhexidine impregnated dressing for peripheral intravenous catheters (PIVCs) to the standard dressing currently used in general medical and surgical inpatient wards.
- Conditions
- Vascular Access Complication, Device Related Infection, Device Related Sepsis, Device Site Reactions
- Trial name
- ProP (NCT05741866)
- Testing
- Chlorhexidine gluconate impregnated bordered polyurethane dressing, Standard bordered polyurethane dressing
- Where
- 3 sites in Australia, France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Myocardial Infarction
Intracoronary Darbepoetin-alpha to Reduce The Infarct Size and Post-Infarct Remodeling
Prospective, randomized and open label trial Hypothesis Infusion of intracoronary darbepoetin-alpha at the time of reperfusion may reduce infarct size and post-infarct pathologic left ventricular remodeling in patients with…
- Trial name
- NCT01538771
- Testing
- Darbepoetin alfa, Control Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Bundang Hospital
Reperfusion Injuries, Myocardial
The Role of Mitochondrial Respiration in the Cardioprotective Capacity of IPC in Diabetic and Non-diabetic Patients
The overall aim of this study is to examine the role of mitochondrial respiration in human diabetic tissue before and after ischemia.
- Trial name
- NCT02993484
- Testing
- Dimethyl Malonate, Ischemic preconditioning, Ischemia reperfusion
- Volunteers
- 39 people
- Sponsor
- University of Aarhus
Hypotension, ENT Disease
Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery
The aim of the project is to investigate whether the use of the HPI can reduce the number and duration of intra- and postoperative hypotension in ventilated patients during and two hours after extensive surgery in the head and…
- Conditions
- Hypotension, ENT Disease, Acute Kidney Injury, Anesthesia
- Trial name
- NCT04151264
- Testing
- Hypotension probability index (HPI)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- University of Giessen
Neurological Injury, Stroke
Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.
The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2…
- Conditions
- Neurological Injury, Stroke, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- CANON (NCT03074604)
- Testing
- aortic no-touch OPCABG, OPCABG with partial clamp applying carbon dioxide, OPCABG with partial clamp
- Where
- Poland
- Volunteers
- 192 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Out-Of-Hospital Cardiac Arrest, Post-Cardiac Arrest Syndrome
The Danish Out-of-Hospital Cardiac Arrest Study
After resuscitation from Out-of-Hospital Cardiac Arrest (OHCA) patients experience Post Cardiac Arrest Syndrome due to ischemia and reperfusion injury.
- Trial name
- DANOHCA (NCT05895838)
- Testing
- Dexamethasone, Backrest elevation, Early wakeup call
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Christian Hassager
Postoperative Delirium, Aortic Valve Stenosis
Assessing the Incidence of Postoperative Delirium Following Aortic Valve Replacement
Our primary aim in this observational study is to identify the incidence of POD in the first five postoperative days by using the 3-minute Diagnostic confusion assessment method (3D-CAM), the derived version for intensive care…
- Trial name
- IPOD-AV (NCT03950440)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven