Clinical trials: Postoperative Cardiovascular Complication
Microsurgical Free Flaps
Sevoflurane Protective Effect on Ischemia-reperfusion Injury. Multicenter, Randomized Controlled Trial
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil).
- Trial name
- NCT01905501
- Testing
- Balanced anesthesia, Total intravenous anesthesia
- Where
- Italy
- Volunteers
- 132 people
- Sponsor
- Regina Elena Cancer Institute
Ischemia-reperfusion Injury
Remote Ischemic Postconditioning Increases HIF-1α Plasma Levels and Improves Cardiac Markers After Cardiac Surgery
Background. Cardiopulmonary bypass in on-pump cardiac surgery (OPCS) can have harmful effects by ischemia-reperfusion. No data about the effects of remote ischemic postconditioning (RIP) in hypoxia-inducible factor-1 alpha…
- Trial name
- NCT04284592
- Testing
- Remote ischemic post-conditioning (RIP)
- Volunteers
- 70 people
- Sponsor
- José García de la Asunción
Ischemic Preconditioning
The Study of Potency of Cross-preconditioning to Prevent Ischemic-reperfusion Injury for Heart Transplantation Recipient
In recent years, a large number of studies confirmed the protective effect of ischemic preconditioning on myocardium against ischemia/reperfusion injury, but the clinical data of the effectiveness of ischemic preconditioning in…
- Trial name
- NCT03900390
- Testing
- cross-preconditioning
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Mengya Liang
Leg Ulcers Venous, Dehiscence, Surgical Wound
Blu Light for Ulcers Reduction
Multi-center study on the effectiveness of treatment with a blue light medical device (EmoLED) in the reduction of ulcer surface in 10 weeks.
- Trial name
- BLUR (NCT04018924)
- Testing
- Illumination with blue light (400-430nm) for 60 seconds with a power density of 120mW/sqcm (EmoLED device)
- Where
- 7 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Emoled
Venous Thrombosis
Study of Arixtra (Fondaparinux Sodium) to Prevent Blood Clots in Women Undergoing Abdominopelvic Surgery for Likely Gynecologic Malignancy
This is a randomized trial to compare intermittent compression devices with or without post-operative Arixtra (fondaparinux sodium) in women undergoing major abdominal surgery for known or presumed gynecologic malignancies.
- Trial name
- NCT00539942
- Testing
- Arixtra (fondaparinux sodium), Intermittent compression devices (ICD)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Fetal Hypoxia, Reperfusion Injury
Antenatal Allopurinol During Fetal Hypoxia
A former study (submitted) in 32 severely asphyxiated infants participating in a randomized double blind study, in which early postnatal allopurinol or a placebo (within 4 hours after birth) was administered to reduce free…
- Trial name
- NCT00189007
- Testing
- Allopurinol sodium, Mannitol
- Where
- 11 sites in Netherlands
- Volunteers
- 222 people
- Sponsor
- UMC Utrecht
Heart Failure, Right Ventricular Dysfunction
Mitigating Post-Op RV Dysfunction After LVAD Implantation
This project evaluates right ventricle (RV) protective strategies after left ventricular assist device (LVAD) implantation.
- Conditions
- Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- NCT05758194
- Testing
- Standardized RV Management, Usual Care RV Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Intra Abdominal Pressure, Abdominal Compartment Syndrome
Intra-abdominal Hypertension and Abdominal Compartment Syndrome in Patients After Pancreatic Procedures.
This study investigates the development of intra-abdominal hypertension and compartment syndrome in patients undergoing elective pancreatic procedures.
- Conditions
- Intra Abdominal Pressure, Abdominal Compartment Syndrome, Pancreatic Surgery, Pancreatic Fistula After Pancreaticoduodenectomy
- Trial name
- HYPA (NCT06672601)
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Charles University, Czech Republic
Anesthesia
General Anesthetic Mode and Postoperative Complications
The relationship between anesthetic medication and postoperative major cardiac and cerebral complications will be studied using logistic regression model.
- Trial name
- NCT03335579
- Testing
- inhalation or propofol ,epidural or general anesthesia, remifentanil or sufentanil
- Volunteers
- 50,000 people
- Sponsor
- Peking University First Hospital
Diabetes
Nitrite Infusion in Islet Cell Transplantation
This study seeks to investigate the effects of administering nitrite to pancreatic islet cells that have been removed from a patient for autotransplantation.
- Trial name
- NCT03544242
- Testing
- Control, Pre-Isolation Infusion, Post-Isolation Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Primary Graft Dysfunction
Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience
Among the complications of heart transplant, primary dysfunction of the graft (PDG) is the most feared with a net impact on early morbidity and mortality.
- Trial name
- NCT03156894
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Reperfusion Injury
Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.
- Trial name
- NCT02394405
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Postoperative Cognitive Dysfunction, Coronary Artery Disease
Short-Term and Long-Term Cognitive Outcomes in Adults After Cardiac Surgery
Adults with coronary artery disease (250 patients) undergoing cardiac surgery participated in the study. The aim is to investigate short-term and long-term cognitive outcomes and the patterns of organization of functional brain…
- Trial name
- NCT05172362
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications
Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial
Hospitalization in pregnancy and childbirth greatly increases the thromboembolic risk of these patients. The application of a protocol for assessing the risk of VTE reduces mortality and morbidity of these phenomena.
- Conditions
- Thrombophilia Associated With Pregnancy, Perioperative/Postoperative Complications, Venous Thrombosis, Pulmonary Embolism
- Trial name
- NCT02600260
- Testing
- Enoxaparin, No intervention
- Where
- Brazil
- Volunteers
- 7,212 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction, Reperfusion Injury
Prevention of Reperfusion Injury Outcomes Through Effective Cardioprotection Targeting Myocardial Infarction
This study is open to adults with ST elevation myocardial infarction (heart attack) undergoing primary percutaneous coronary intervention (PCI).
- Conditions
- Myocardial Infarction, Reperfusion Injury, AMI, STEMI (ST Elevation MI)
- Trial name
- PROTECT-MI (NCT07362446)
- Testing
- Xolatryp
- Where
- 8 sites in Australia
- Volunteers
- 300 people
- Sponsor
- Nyrada Pty Ltd
Ischemia-Reperfusion Injury, Myocardial Infarction
Infusion of a Single Dose of Erythropoietin to Prevent Injury in an Ischemia Reperfusion Forearm Model
Rationale: The investigators hypothesize that EPO protects against apoptosis after acute ischemia in man and that it is detectable using the annexin-A5 model.
- Trial name
- IPIIR (NCT00691613)
- Testing
- Epoetin alpha, NaCl
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Post-Cardiac Arrest Syndrome
Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest
XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature…
- Trial name
- XePOHCAS (NCT03176186)
- Testing
- Xenon
- Where
- 10 sites in United States, Denmark
- Volunteers
- 1,436 people
- Sponsor
- Invero Pharma, Inc.
Left Ventricular Diastolic Dysfunction
Left Ventricular Diastolic Function During Anesthesia Induction
Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on…
- Trial name
- NCT03522194
- Testing
- Sevoflurane, Propofol
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hepatectomy, Reperfusion Injury
N-acetylcysteine to Reduce Ischemia/Reperfusion Injury in Liver Resection
Study hypothesis: N-acetylcysteine (NAC) can reduce ischemia/reperfusion injury in liver resection performed under ischemic preconditioning and intermittent portal triad clamping.
- Trial name
- NCT01223326
- Testing
- Acetylcysteine (NAC), Saline
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated