Clinical trials: Postoperative Cardiovascular Complication
Cardiac Disease
Opioid Reduced Anesthesia With Parasternal CATheters on Postoperative Delirium After Cardiac Surgery
PostOperative Delirium (POD) is the most common neuropsychiatric complication following cardiac surgery and may be related to morphine consumption.
- Trial name
- ORACAT (NCT05880615)
- Testing
- collection of datas
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cardiovascular Disease
Exercise Test and Cardiac Injury
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply…
- Trial name
- NCT01660828
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Cardiac Surgery, Vasoplegia
Reducing Acute Kidney Injury Occurence by Administering Angiotensin II
The aim of this study is to evaluate whether adding angiotensin II to the standard of care is superior compared to the standard of care alone with respect to kidney damage (personalized approach) after cardiac surgery.
- Conditions
- Cardiac Surgery, Vasoplegia, Hyperreninemia
- Trial name
- AIDED (NCT05199493)
- Testing
- Angiotensin II, Control
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Pancreatic Neoplasms, Hypotension
Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia
This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy.
- Conditions
- Pancreatic Neoplasms, Hypotension, Pancreatoduodenectomy
- Trial name
- NCT06953193
- Testing
- General Anesthesia, Combined General Anesthesia (Thoracic Epidural)
- Where
- Mexico
- Volunteers
- 206 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University
Reperfusion Injury After Pulmonary Thromboendarterektomy
High PEEP Application Following Pulmonary Thromboendarterectomy; Does it Have Any Impact on Outcome?
Investigation of the effect of intraoperative lung protection high PEEP maneuver on ischemic reperfusion injury in patients undergoing pulmonary endarterectomy.
- Trial name
- NCT03806504
- Testing
- PEEP, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Hemorrhoid
Laser Hemorrhoidoplasty Versus Open Hemorrhoidectomy for Postoperative Pain
Hemorrhoidal disease is a common condition that can cause symptoms such as rectal bleeding and protrusion of tissue through the anal canal.
- Trial name
- NCT07846904
- Testing
- Open Milligan-Morgan Hemorrhoidectomy, Laser Hemorrhoidoplasty
- Volunteers
- 68 people
- Sponsor
- Allied Hospital Faisalabad
Atrial Fibrillation and Flutter, Atrial Fibrillation
A Clinical Trial of the Use of Remote Heart Rhythm Monitoring With a Smartphone After Cardiac Surgery
The objective of the study is to evaluate the clinical consequences following the detection of postoperative atrial fibrillation or flutter (POAF) using a remote heart rhythm monitoring strategy with a photoplethysmography based…
- Conditions
- Atrial Fibrillation and Flutter, Atrial Fibrillation, Postoperative Complications, Arrhythmia
- Trial name
- SURGICAL-AF 2 (NCT05509517)
- Testing
- Photoplethysmography based smartphone application for heart rhythm analysis (FibriCheck™)
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urologic Cancer, Thrombosis
Thrombembolism After Robot- Assisted Surgery in Urology
Cancer patients have an increased risk of perioperative complications undergoing surgery procedures. Postoperative complications caused by thrombembolic events after robot- assisted surgery in major urological procedures have…
- Conditions
- Urologic Cancer, Thrombosis, Embolism, Surgery--Complications
- Trial name
- NCT04796740
- Where
- Germany
- Volunteers
- 450 people
- Sponsor
- University Hospital Schleswig-Holstein
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiac Arrest
Reoxygenation After Cardiac Arrest (REOX Study)
The broad objective of this study is to test the association between hyperoxia exposure after resuscitation from cardiac arrest and outcome.
- Trial name
- REOX (NCT01881243)
- Where
- 5 sites in United States
- Volunteers
- 280 people
- Sponsor
- The Cooper Health System
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Diseases of Mitral Valve, Aortic Valve Disorder
Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery
The purpose of this study is to examine the wound infusion of articaine for treatment of acute post-sternotomy pain in a placebo-controlled manner using a prospective and randomized design and an active control (bupivacaine)
- Conditions
- Diseases of Mitral Valve, Aortic Valve Disorder, Atrial Septal Defects, Intracardiac Myxoma
- Trial name
- NCT01536717
- Testing
- Articaine hydrochloride 2% solution, Sodium Chloride
- Where
- 2 sites in Finland
- Volunteers
- 36 people
- Sponsor
- Helsinki University Central Hospital
Ankle Motion, Gynecologic Neoplasm
Functional Training for the Prevention of Deep Venous Thrombosis
This study aims to analyze the post-operative functional training on the prevention of deep venous thrombosis (DVT) in the patients who have accepted major surgeries for the gynecological malignancies.
- Conditions
- Ankle Motion, Gynecologic Neoplasm, Deep Venous Thrombosis, Abdominal Breathing
- Trial name
- NCT03740633
- Testing
- passive ankle pump motions on the day of surgery, active ankle pump motions and abdominal breathing training on the 1-3 day after the surgery, Regular care
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Lei Li
Abdominal Aortic Aneurysm, Endoleak
Predicting Endoleaks Following Endovascular Aortic Aneurysm Repair Using 18F-Sodium Fluoride
The purpose of the study is to describe Sodium Fluoride uptake (using Positron Emission Tomography-Computed Tomography - PET-CT) following Endovascular Aneurysm Repair (EVAR) and to determine whether Sodium Fluoride PET-CT can…
- Conditions
- Abdominal Aortic Aneurysm, Endoleak, Stent-Graft Endoleak
- Trial name
- PET-EVAR (NCT04577716)
- Testing
- 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography, CT Aortic Angiogram, 12-month CT Aortic Angiogram
- Where
- 4 sites in United Kingdom
- Volunteers
- 102 people
- Sponsor
- University of Edinburgh
ERAS Programmes
EFFECTS OF ERAS PROTOCOLS ON PATIENT OUTCOMES IN CARDIOVASCULAR SURGERY
A randomized controlled experimental study has been conducted to determine the effects of Enhanced Recovery After Surgery (ERAS) protocols on patient outcomes in the Cardiovascular Surgery Clinic.
- Trial name
- NCT07817264
- Testing
- Enhanced Recovery After Surgery (ERAS) Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Karabuk University
Anesthesia, Postoperative Pain
RIB for Perioperative Analgesia in CIED Patients
Rhomboid intercostal plane block (RIB) has been described in the last decade. Various clinical applications have been found to provide hemithorax analgesia.
- Conditions
- Anesthesia, Postoperative Pain, Arrhythmias, Cardiac
- Trial name
- NCT06449599
- Testing
- ultrasound, parenteral local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul University - Cerrahpasa
Anastomotic Leak, Colorectal Cancer
The Prediction of Anastomotic Insufficiency Risk After Colorectal Surgery (PANIC) Study
The Prediction of Anastomotic Insufficiency risk after Colorectal surgery (PANIC) study aims to establish a machine-learning-based application that allows for accurate preoperative prediction of patients at risk for anastomotic…
- Conditions
- Anastomotic Leak, Colorectal Cancer, Diverticulosis, Crohn Disease
- Trial name
- NCT04985981
- Where
- 2 sites in Switzerland
- Volunteers
- 11,000 people
- Sponsor
- Michel Adamina, MD