Clinical trials: Postoperative Cardiovascular Complication
Aortic Aneurysm, Postoperative Nausea and Vomiting
AoA Guided Thoracic Epidural Analgesia for Abdominal Aortic Repair
The aim of this randomized trial is to assess the efficacy of analgesia using either thoracic epidural or intravenous infusions for open lumbar infrarenal aortic aneurys repair and compare Numerical Rating Scale (NRS) with…
- Conditions
- Aortic Aneurysm, Postoperative Nausea and Vomiting, Postoperative Pain, Haemodynamic Stability
- Trial name
- AoA-AAA (NCT06609993)
- Testing
- intravenous rescue opioid analgesia using fentanyl, intravenous rescue atropine administration, intravenous rescue urapidil administration
- Where
- Poland
- Volunteers
- 75 people
- Sponsor
- Michał Stasiowski
Hemorrhoids, Postoperative Pain
Ice Packing Versus Warm Sitz Baths After Hemorrhoidectomy
Warm sitz baths are commonly recommended after hemorrhoidectomy, although their benefit for early postoperative recovery remains uncertain. Local cold application may reduce postoperative pain and perianal swelling.
- Trial name
- NCT07843563
- Testing
- Cryotherapy (Ice Packing), Warm Sitz Bath
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people
- Sponsor
- Memorial Atasehir Hospital
Cardiac Disease, Surgery
Parasternal Block Combined With Rectus Sheath Block for Cardiac Surgery Under Sternotomy
The aim of this randomized controlled trial is to examine the effect of ultrasound guided bilateral Parasternal Nerve Block combined with rectus sheath block on preoperative analgesia, opioid consumption and respiratory function…
- Conditions
- Cardiac Disease, Surgery, Analgesia, Acute Pain
- Trial name
- PARARECTUS (NCT05764616)
- Testing
- PARASTERNAL BLOCK, LOCAL INFILTRATION OF DRAINAGE EXIT SITES, RECTUS SHEATH BLOCK
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Campus Bio-Medico University
Liver Transplant
Safety and Efficacy of Perioperative Remodulin® in Orthotopic Liver Transplant Recipients
Patients undergoing orthotopic liver transplant will experience some degree of clinical and/or biochemical hepatic dysfunction. This early injury is known as primary graft dysfunction and varies from minor abnormalities to…
- Trial name
- NCT01884038
- Testing
- treprostinil sodium
- Where
- United States
- Sponsor
- United Therapeutics
Hemorrhoid, Postoperative Pain
"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy")
This study is being conducted at the Department of General Surgery, King Edward Medical University, Lahore, Pakistan. The purpose of the trial is to compare the effectiveness of topical Lignocaine ointment versus topical Glyceryl…
- Trial name
- NCT07159334
- Testing
- Lignocaine Ointment, Glyceryl Trinitrate Ointment 0.2%
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- King Edward Medical University
Survival, Prosthesis, Prosthesis Durability
SPAnish Aortic VALVE Multicentric Study
Currently there is an increase in the use of bioprosthesis worldwide (> 70% according to national data of the Spanish Society of Thoracic and Cardiovascular Surgery).
- Conditions
- Survival, Prosthesis, Prosthesis Durability, Valve Heart Disease
- Trial name
- SPAVALVE (NCT03595423)
- Testing
- Surgical AVR with bioprosthetic or mechanical prosthesis
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Cardiac Disease, Device Related Infection
Application of Radiomics for Diagnosis and Follow-up of Cardiovascular Device Infections: PREDICT Study
Single center, open-label, phase IV clinical trial to study the application of radiomics in molecular imaging for diagnosis and follow-up of CVDIs.
- Trial name
- PREDICT (NCT07454096)
- Testing
- PET/CT imaging
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Intraoperative Hypotension, Pulmonary Complication
Perioperative Goal Directed Therapy (PGDT) in Spinal Surgery in the Prone Position
This study aims at evaluating if a specific protocol, that can be framed in the innovative concept of Perioperative Goal Directed Therapy (PGDT), based on the evaluation of the Stroke Volume Variation (SVV) - a parameter deriving…
- Conditions
- Intraoperative Hypotension, Pulmonary Complication, Cardiovascular Complication
- Trial name
- PGDT (NCT04025086)
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Catania
Postoperative Delirium, Postoperative Stroke
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared…
- Conditions
- Postoperative Delirium, Postoperative Stroke, Postoperative Cognitive Dysfunction
- Trial name
- PRECISION (NCT05595954)
- Testing
- Preoperative data collection, Intraoperative NIRS, Intraoperative TCD
- Where
- 4 sites in Switzerland, United Kingdom
- Volunteers
- 500 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium (POD), Postoperative Bleeding
GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.
The goal of this observational cohort study is to prove whether genetic, epigenetic, transcriptomic, proteomic, metabolomic, imaging, voice, and clinical markers can improve prediction of early complications after cardiac surgery…
- Conditions
- Postoperative Delirium (POD), Postoperative Bleeding, Acute Kidney Injury, Atrial Fibrillation (AF)
- Trial name
- GENECARD (NCT07345403)
- Testing
- Multi-Omics Data and Clinical Data Collection
- Where
- Poland
- Volunteers
- 3,000 people
- Sponsor
- Medical University of Gdansk
Hip Fractures, Hypotension on Induction
Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study.
Background During anaesthesia for repair of a broken hip, many patients experience low blood pressure. There have been many studies showing that patients who experience low blood pressure during anaesthesia are at increased risk…
- Conditions
- Hip Fractures, Hypotension on Induction, Intraoperative Hypotension, Acute Kidney Injury
- Trial name
- iSTABILISE (NCT04051073)
- Testing
- Continuous non-invasive blood pressure monitoring
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Arterial Obstructive Diseases
Trial Using Integuseal as Microbial Sealant for Arterial Bypass Surgery on Lower Extremities
The purpose of this study is to prove a reduction of postoperative wound infections after direct preoperative use of a microbial sealant in the form of Integuseal for vascular procedures on lower extremities.
- Trial name
- ITT (NCT00940979)
- Testing
- Application of Integuseal sealant
- Where
- 3 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- Rijnstate Hospital
Adrenaline; Aortic Dissection; Drug Dose; Nervous System; Ischemia Reperfusion Injury
Effects of Different Doses of Epinephrine on Biomarkers of Nervous System Ischemia-reperfusion Injury in Patients With Stanford Type A Dissection
Aortic dissection is the most common aortic disease leading to death. Among them, patients with Stanford type A dissection (TAAD) are prone to dissection rupture in the early stage, and their condition deteriorates rapidly.
- Trial name
- NCT05151536
- Volunteers
- 132 people
- Sponsor
- Yunlong Fan
Reperfusion Injury
Effect of Pneumoperitoneum on Human Ovary
Laparoscopic surgery has played a pivotal role in all surgical fields in modern medicine. It has some well known advantages over open surgery.
- Trial name
- NCT02731651
- Testing
- open hysterectomy, laparoscopic assisted vaginal hysterectomy
- Volunteers
- 20 people
- Sponsor
- Ege University
Cardiac Complications, Cardiac Surgery
Propofol vs Sevoflurane in Cardiac Surgery
The hypothesis of our study: presence of a relationship between the type of anesthesia and complications after cardiac surgery. The aim is to assess the benefit of using intravenous or inhaled anesthesia on the patients\'…
- Conditions
- Cardiac Complications, Cardiac Surgery, Neurologic Complications, Respiratory Complications
- Trial name
- NCT06729086
- Testing
- sedation using propofol, sedation using sevoflurane
- Volunteers
- 100 people
- Sponsor
- Saint-Joseph University
Cesarean Section, Hypotension Drug-Induced
Bupivacaine 5 mg vs 7.5 mg for Spinal Anesthesia in Cesarean Delivery in Indonesian Population
This study aims to evaluate the efficacy of hyperbaric 5 mg bupivacaine + fentanyl 25 mcg versus hyperbaric 7.5 mg bupivacaine + fentanyl 25 mcg to lower incidence of hypotension
- Conditions
- Cesarean Section, Hypotension Drug-Induced, Spinal Anesthesia, Postoperative Complications
- Trial name
- NCT03834454
- Testing
- Bupivacaine
- Where
- Indonesia
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Chronic Subdural Hematoma, Subdural Hematoma
Non-Thermal Plasma to Reduce Recurrence in Chronic Subdural Hematoma
The goal of this randomized controlled trial is to evaluate whether the adjuvant application of non-thermal plasma (NTP) during standard surgical drainage of chronic subdural hematoma (cSDH) can reduce the recurrence rate at 6…
- Conditions
- Chronic Subdural Hematoma, Subdural Hematoma, Recurrence, Postoperative Complications
- Trial name
- NCT07656818
- Testing
- Standard Surgery Protocol, Non-Thermal Plasma
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Benjamín Gonzalo Rodríguez Méndez
Varicose Veins, Quality of Life
Evaluating QoL and Postoperative Complications Using TEThA Technique in the Treatment of Tributary Veins
Endovenous laser thermoablation is a well-established alternative for the treatment of tributary veins. We believe that it is possible to improve the techniques described in the literature, aiming not only to allocate the laser…
- Conditions
- Varicose Veins, Quality of Life, Laser
- Trial name
- TEThA (NCT06669260)
- Testing
- TEThA technique
- Volunteers
- 20 people
- Sponsor
- Nara Medeiros Cunha de Melo Vasconcelos
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Juxtarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm
Modified Preloaded System for Renal Arteries in Fenestrated Endografting (MPSRA)
Advanced Endovascular repair of aneurysms and dissections involving thoraco-abdominal (type I-IV) and complex abdominal (juxta and para-renal) aorta is a ground-gaining procedure allowing favorable results in high surgical risk…
- Conditions
- Juxtarenal Aortic Aneurysm, Thoracoabdominal Aortic Aneurysm, Pararenal Aortic Aneurysm, Aortic Aneurysm, Thoracoabdominal
- Trial name
- MPSRA (NCT05224219)
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Bologna