Clinical trials: Postoperative Cardiovascular Complication
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Ischemic Stroke
Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study
Ischaemic stroke causes significant morbidity and mortality and is a leading cause of disability within an ageing United Kingdom (UK) population.
- Trial name
- RICE PAC (NCT03152799)
- Testing
- RIPC Remote Ischaemic Pre-Conditioning
- Volunteers
- 60 people
- Sponsor
- University College, London
Hypertensive Disease, Pain, Postoperative
Effect of Acute Arterial Hypertension on Morphine's Requirements and Postsurgical Pain.
The purpose of this randomized clinical trial is to evaluate the effect of acute arterial hypertension maintained during surgery on morphine's requirements in patients undergoing laparoscopic cholecystectomy
- Trial name
- NCT01897155
- Testing
- SBP 20-30% over baseline, SBP 20-30% under baseline
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ischemia Reperfusion Injury
Desflurane Preconditioning in Hepatectomies
Hepatectomies are considered as operations of high bleeding risk. The history of massive hemorrhage in liver surgery led to the emergence of techniques to control excessive blood loss.
- Trial name
- NCT03848780
- Testing
- Desflurane
- Volunteers
- 46 people
- Sponsor
- Aristotle University Of Thessaloniki
Preoperative Care, Surgery--Complications
Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study
The proportion of noncardiac surgeries performed as same-day surgery is increasing worldwide, with more complex surgeries being performed on higher risk patients in the outpatient setting.
- Conditions
- Preoperative Care, Surgery--Complications, Myocardial Infarction
- Trial name
- VALIANCE (NCT04973397)
- Where
- 16 sites in United States, Canada and 2 more
- Volunteers
- 15,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ischaemia-reperfusion Injury
Ischaemia-réperfusion During the Coronary Surgery With Beating Heart
Less oxidative stress occurs during off-pump than on-pump coronary artery bypass graft (CABG) surgery but warm ischaemia-reperfusion injury may occur following transient coronary artery clamping.
- Trial name
- NCT01771978
- Testing
- Diltiazem, Acetylcystein, diltiazem and acetylcystein
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
Myocardial Infarction
Exenatide for Myocardial Protection During Reperfusion Study
This study aims to assess the effect of exenatide on myocardial injury in patients undergoing emergent percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction or heart attack (STEMI).
- Trial name
- EMPRES (NCT01938235)
- Testing
- Exenatide
- Where
- 10 sites in Canada
- Volunteers
- 198 people
- Sponsor
- University Health Network, Toronto
Scheduled Cardiac Surgery With Extracorporeal Circulation, Vasoplegic Syndrome
Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation
This is a randomized, double blind, multicenter study following surgery with extracorporeal circulation to compare blood pressure optimization with vasopressin versus noradrenaline.
- Trial name
- NOVACC (NCT05568160)
- Testing
- Vasopressin, Norepinephrine, Collection of clinical data
- Where
- France
- Volunteers
- 840 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Non-Dialysis Dependent Severe Renal Dysfunction, Cardiovascular Disease
Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery
The purpose of this study is to determine whether preoperative hemodialysis or intraoperative modified ultrafiltration are effective for patients with non-dialysis dependent severe renal dysfunction undergoing open heart surgery.
- Trial name
- SeRenaD-CPB (NCT00720967)
- Testing
- Open Heart Surgery (OHS), Intraoperative Modified Ultrafiltration (MUF), Hemodialysis (HD)
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 450 people
- Sponsor
- University Hospital, Geneva
Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment
Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest
The SAVE-J NEUROTHERM trial is a cluster randomized trial that evaluated and compared the mortality risk, neurological outcomes, and adverse events between patients who underwent hypothermia and those who underwent normothermia…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), ECMO Treatment, Temperature, Post Cardiac Arrest Syndrome
- Trial name
- J-NEURO (NCT06776549)
- Testing
- Temperature control
- Where
- 29 sites in Japan
- Volunteers
- 468 people
- Sponsor
- Kagawa University
Hemorrhoids, Hemorrhoids Third Degree
PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study)
The goal of this clinical trial is to learn if the sacral erector spinae plane block can provide equal or better pain control than the pudendal nerve block in adults undergoing hemorrhoid surgery.
- Trial name
- PUSHES (NCT07350460)
- Testing
- Pudendal block AL, Sacral ESP block AL
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Andrea Saporito
Cardiac Catheterization, Electrophysiology Procedure
Post Anesthesia Care Unit (PACU) Weighted Blanket Study
This study is being conducted to evaluate the safety and efficacy of weighted blankets to reduce agitation in patients in the post-procedural phase after cardiac catheterization and electrophysiology procedures in the post…
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Trial name
- NCT05632640
- Testing
- Standard of Care, Weighted blanket
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan