Clinical trials: Postoperative Circulatory Changes
Cardiac Arrest (CA), Post Cardiac Arrest Syndrome
Survival After Cardiac Arrest: How New Treatment Guidelines Changed Patient Outcomes.
The goal of this retrospective observational cohort study is to evaluate whether the progressive implementation of updated post-cardiac arrest care guidelines has improved survival and neurological recovery in adult patients…
- Trial name
- RetroAC (NCT07649889)
- Testing
- post-resuscitation care
- Where
- Italy
- Volunteers
- 630 people
- Sponsor
- Azienda Sanitaria Universitaria Integrata del Trentino
Acute Ischemic Stroke
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury.
- Trial name
- NCT04916197
- Testing
- Dexmedetomidine prolonged sedation, 0.9% saline
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Beijing Chao Yang Hospital
Myocardial Ischemia, Heart Defects, Congenital
Spectroscopic Assessment of Myocardial Oxygenation Changes in Pediatric Heart Surgery
The goal of this observational study is to investigate the ability of the SpectroCor Tissue Oxygenation Monitor and its accessory SpectroCor Sensor to observe and monitor changes in cardiac oxygen availability in pediatric…
- Conditions
- Myocardial Ischemia, Heart Defects, Congenital, Reperfusion Injury, Myocardial
- Trial name
- NCT07785141
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Spectrocor
Breast Cancer, Lymphedema
Vascular Changes Due to Different Treatments of Lymphedema Secondary to Postoperative Breast Cancer
The objective of this study is to evaluate the effect of elastic compression, functional compressive bandaging (ECF) and active exercises in the bloodstream of the upper member ipsilateral to the surgical procedure for the…
- Trial name
- NCT02517086
- Testing
- therapeutic exercises, elastic compression, functional compressive bandaging
- Volunteers
- 3 people
- Sponsor
- University of Sao Paulo
Myocardial Infarction, ST-Elevation Myocardial Infarction (STEMI)
Intracoronary Hypothermia as a Prevention of Reperfusion Injury in Myocardial Infarction.
Acute myocardial infarction with ST segment elevation is often accompanied by a totally occluded coronary artery. Which has deleterious effects on heart muscle.
- Conditions
- Myocardial Infarction, ST-Elevation Myocardial Infarction (STEMI), Reperfusion Injury, Microvascular Occlusion
- Trial name
- NCT06567249
- Testing
- Intracoronary hypothermia, Standard percutaneous coronary intervention
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Orthognathic Surgery
Evaluation of the Mental Foramen After Surgery Via Ultrasonography
Objective: This study aims to detect changes in blood flow in the mental foramen after surgery compared to before orthognathic surgery.
- Trial name
- Blood flow (NCT06661798)
- Testing
- orthognathic surgery, USG examination, Subjective evaluation - Neuro-sensitivity tests
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Bezmialem Vakif University
Out of Hospital Cardiac Arrest, Inflammatory Response
Hypothermia After Cardiac Arrest - Effects on Myocardial Function and Inflammatory Response.
The on-going randomized clinical trial TTM2 (Target Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest, NCT02908308) investigates if there is a difference in mortality, neurological function or quality…
- Conditions
- Out of Hospital Cardiac Arrest, Inflammatory Response, Ischemia Reperfusion Injury, Hypothermia
- Trial name
- IH3 (NCT03743584)
- Testing
- Targeted temperature management, Standard care, early treatment of fever
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Hypertension, Diabetes Mellitus, Type 2
Does Early Weight Loss Following Laparoscopic Sleeve Gastrectomy Affect Long-term Outcomes
A study to explore the relationship between early weight loss in the 4 weeks following laparoscopic sleeve gastrectomy and outcomes, in terms of weight loss and comorbidity improvement, 7 years following the surgery.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Gastrostomy, Morbid Obesity
- Trial name
- NCT04235829
- Testing
- Laparoscopic sleeve gastrectomy
- Where
- Israel
- Volunteers
- 156 people
- Sponsor
- Shaare Zedek Medical Center
Postoperative Circulatory Changes, Peripheral Vascular Diseases
Effects of Different Compression Pressure Levels on Peripheral Circulation After Surgery
After surgery, elastic compression is commonly used on the legs to support blood circulation and reduce the risk of complications such as swelling and venous thromboembolism.
- Conditions
- Postoperative Circulatory Changes, Peripheral Vascular Diseases, Venous Insufficiency of Leg
- Trial name
- COMP-PILOT (NCT07394829)
- Testing
- Pressure-Controlled Compression Device
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Agri Ibrahim Cecen University
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Hemorrhoids, Open Hemorrhoidectomy
Hemorrhoids: Options of Traditional Hemorrhoidectomy
The goal of this prospective clinical trial is to compare the outcomes of several technical options of open hemorrhoidectomy in patients with symptomatic hemorrhoids.
- Trial name
- NCT06132152
- Testing
- Open hemorrhoidectomy with 'cold' scalpel, Open hemorrhoidectomy with electrosurgical scalpel
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- Center of Endourology "Endocenter"
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Myocardial Infarction, Myocardial Reperfusion Injury
Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether treatment of patients suffering from ST-elevation myocardial infarction (STEMI) with 1-2 liters of cold saline and central venous catheter cooling with Philips InnerCool RTx…
- Conditions
- Myocardial Infarction, Myocardial Reperfusion Injury, Anterior Wall Myocardial Infarction, Inferior Wall Myocardial Infarction
- Trial name
- CHILL-MI (NCT01379261)
- Testing
- Cooling
- Where
- 10 sites in Austria, Denmark and 2 more
- Volunteers
- 120 people
- Sponsor
- Region Skane
Arrythmia, Pain, Acute
Stellate Ganglion Block in Control of Arrhythmia in Laparoscopic Cholecystectomy
During Laparoscopic cholecystectomy, carbon dioxide (CO2) pneumoperitoneal laparoscopic surgery, CO2-pneumoperitoneum activates the sympathoadrenomedullary system to increase the release of catecholamines such as epinephrine (E)…
- Trial name
- NCT04837495
- Testing
- right stellate ganglion block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Heart; Dysfunction Postoperative, Cardiac Surgery, Myocardial Infarction
High-sensitivity Troponin in Cardiac Surgery
Among patients undergoing heart surgery, a measurable degree of heart muscle tissue injury is expected. The level of injury can be shown by measuring the blood levels of specific molecules called cardiac biomarkers.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Myocardial Infarction, Myocardial Injury
- Trial name
- NCT01913873
- Testing
- serum concentration changes cardiac biomarkers
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Onze Lieve Vrouw Hospital
Atrial Fibrillation
The Effect of Magnesium Therapy to Prevent Post-operative Atrial Fibrillation After Cardiac Surgery in Adults
It is well known that magnesium sulfate has a membrane stabilizing effect , and broad spectrum anti arrhythmic properties. In this trial, the investigators study its prophylactic effect against atrial fibrillation in…
- Trial name
- NCT02928315
- Testing
- Magnesium Sulfate, control
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Geriatric Patients, Postoperative Complications
PREDICTING MINS WITH FRAILTY AND BIOMARKERS IN GERIATRIC SURGERY
The primary objective of this study is to develop and validate a machine learning model that integrates preoperative clinical data, biomarkers, and modified frailty indices (mFI-5) to accurately predict myocardial injury after…
- Conditions
- Geriatric Patients, Postoperative Complications, Frailty, Myocardial Ischemia
- Trial name
- NCT07566013
- Testing
- Preoperative Risk Assessment and Machine Learning Modeling
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- DİLEK KALAYCI
Abdominal Compartment Syndrome
Intraoperative Peak Airway Pressure Changes on Postoperative Pulmonary Function After Muscle Plication
An abdominal panniculus excision procedure is known as an abdominoplasty (panniculectomy). Musculofascial plication is a crucial aspect of abdominoplasty, especially for patients with significant divarication of the recti…
- Trial name
- NCT06291389
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
Myocardial Reperfusion Injury, Heart Diseases
Coronary Sinus Blood Sevoflurane and Desflurane Concentration and Lactate Changes in Patients Undergoing Heart Surgery
In the last few years, anaesthetics gas such as isoflurane, desflurane and sevoflurane used in heart surgery have shown some benefits to reduce the risk of heart muscle damage than total intravenous anesthetics.
- Conditions
- Myocardial Reperfusion Injury, Heart Diseases, Postoperative Complications
- Trial name
- SEVO-DES (NCT02866630)
- Testing
- Blood samples
- Sponsor
- University of Malaya
Pain, Postoperative, Change; Circulatory
The Influence of Peripheral Nerve Blocks in Patients Undergoing Limb Orthopedic Surgery
To investigate pre-op peripheral nerve block in reducing peri-op IL-6 level and post-op pain
- Conditions
- Pain, Postoperative, Change; Circulatory, Surgical Injury
- Trial name
- NCT03913650
- Testing
- 0.25% bupivacaine
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital