Clinical trials: Postoperative Cognitive Deficit (POCD)
Postoperative Complications
Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome
The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
- Trial name
- NCT02766062
- Testing
- metabolic syndrome
- Volunteers
- 94 people
- Sponsor
- General Hospital of Ningxia Medical University
Postoperative Cognitive Deficit (POCD)
"Effects of Fluid Status and Regional Cerebral Oxygenation on Postoperative Cognitive Dysfunction in Patients Undergoing Lower Extremity Surgery Under General and Spinal Anesthesia."
We frequently encounter cognitive impairments in patients over 65 undergoing Lower extremity surgery, depending on comorbidities and the choice of anesthesia method.
- Trial name
- AECGSKD002 (NCT07302061)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Goztepe Training and Research Hospital
Postoperative Cognitive Dysfunction
Effects of Brain Beta-Amyloid on Postoperative Cognition
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.
- Trial name
- NCT01606488
- Testing
- Florbetapir F 18 (18F-AV-45), no intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Cerebral Saturation, Cognitive Impairment
The Association Between Variation in Oxygen Saturation (ScO2) and Incidence of Postoperative Cognitive Dysfunction (POCD) in a Population of Elderly Patients Admitted for Emergency Surgery.
There is no study of the association between ScO2 and POCD in non-cardiac, thoracic or vascular surgery. The few studies found in cardiac, thoracic and vascular surgery show an incidence up to 50% with a variation of the ScO2…
- Conditions
- Cerebral Saturation, Cognitive Impairment, Emergencies
- Trial name
- NIRS-1 (NCT03107260)
- Testing
- To evaluate the relationship between oxygen saturation and the incidence of postoperative cognitive dysfunction in emergency surgery in elderly patients
- Where
- France
- Volunteers
- 181 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
1. Postoperative Cognitive Dysfunction
POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia
The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's…
- Trial name
- NCT01199913
- Testing
- The intervention will be Mini-Mental Status Examination (MMSE)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Postoperative Cognitive Dysfunction, Delirium, Postoperative
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures.
- Trial name
- NCT07000461
- Testing
- Transcranial Doppler measurement of the middle cerebral artery
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Condition / Focus: Postoperative Cognitive Dysfunction (POCD) Following Spinal Surgery
COMPARISON OF SEVOFLURANE AND PROPOFOL ADMINISTRATION ON POSTOPERATIVE COGNITIVE DYSFUNCTION IN SPINAL SURGERY USING THE MINI-MENTAL STATE EXAMINATION (MMSE)
This study aims to compare the effects of two commonly used anesthetic agents, sevoflurane and propofol, on cognitive function after spinal surgery.
- Trial name
- SEVO-PROP-MMSE (NCT07378878)
- Testing
- Sevoflurane Administration, Propofol Administration
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Universitas Sumatera Utara
Carotid Stenosis, Carotid Artery Diseases
Cerebral Oximetry During Awake Carotid Endarterectomy
Surgery to remove plaque from the carotid artery in the neck requires the artery to be clamped for a period of time. In some patients this reduces blood flow to the brain enough to cause temporary symptoms, and a temporary…
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Brain Ischemia, Carotid Endarterectomy
- Trial name
- COACE (NCT07816081)
- Testing
- Masked continuous cerebral oximetry, Standardised awake neurological test, Serial cognitive assessment
- Where
- Vietnam
- Volunteers
- 150 people
- Sponsor
- Nguyen Toan Thang
Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and…
- Trial name
- NCT07483151
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POCD assessments
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhuan Zhang
Perioperative Care
Improvement of Perioperative Care of Elderly Patients
The focus of this study is the development of a perioperative treatment concept for elderly patients, based on individual necessities and risk factors, aiming to improve patient outcome.
- Trial name
- PeriAge (NCT03325413)
- Testing
- Systematic inclusion of family members, Preoperative information, Physical and breathing exercises
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
POCD - Postoperative Cognitive Dysfunction
Cognitive Dysfunction After Cataract Surgery
Cataract surgery is commonly performed in elderly patients who are at high risk for developing postoperative cognitive dysfunction.
- Trial name
- NCT04730596
- Testing
- Ketamine, Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Melatonin, Cognitive Dysfunction
Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia
This study aims to evaluate the possible effect of melatonin on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing transurethral resection of the prostate (TURP) under spinal anesthesia
- Conditions
- Melatonin, Cognitive Dysfunction, Postoperative Complications, Prostate Hyperplasia
- Trial name
- NCT03966950
- Testing
- melatonin
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cognitive Dysfunction
Postoperative Cognitive Dysfunction as Geriatric Syndrome
This study is testing cognitive function before and after the surgery, with patient's informed consent. Patients of interest are 65 year or older, undergoing surgery in general or regional anesthesia.
- Trial name
- NCT05648890
- Where
- Czechia
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Postoperative Cognitive Dysfunction (POCD), Cardiac Diseases Requiring Surgery
Prediction Model for Postoperative Cognitive Dysfunction in Elderly Cardiac Patients: A Special Disease Cohort Study
This is a prospective cohort study aiming to construct a prediction model for postoperative cognitive dysfunction (POCD) in elderly cardiac patients. We plan to enroll elderly patients aged ≥65 years undergoing cardiac surgery.
- Trial name
- NCT07483047
- Where
- China
- Volunteers
- 634 people
- Sponsor
- Shanghai Geriatric Medical Center
Postoperative Cognitive Dysfunction, POCD
Optimizing Postoperative Cognition the Elderly
This study will recruit surgical patients more than 65 years old. Patients who participate will wear a sticker on their forehead during surgery which monitors their brain waves (electroencephalogram, EEG) and participate in…
- Trial name
- NCT02650687
- Testing
- Processed EEG
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Cognitive Dysfunction
Preoperative Pain and POCD in Elderly Patients
The purpose of this study is to investigate whether preoperative pain is the risk factor of POCD in elder patients.
- Trial name
- NCT03393676
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Delirium, Cognitive Impairment
Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
The purpose of this study is to determine what percentage of patients have cognitive problems (for example, memory or concentration difficulties) after surgery and anesthesia, what the characteristics of these problems are, and…
- Conditions
- Delirium, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- NCT03337282
- Testing
- Protocolized general anesthesia
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Undergoing General Anaesthesia
Risk Factors of POCD in General Anesthesia Patients Underwent Noncardiac and Non Neurological Procedures.
The study was a prospective cohort study to assess the effect of age, duration of anesthesia, repeated surgery, and type of surgery on cognitive impairment in 108 geriatric patients (≥60 years) who underwent general anesthesia…
- Trial name
- NCT04215263
- Testing
- Questionaire
- Where
- Indonesia
- Volunteers
- 109 people
- Sponsor
- Universitas Indonesia
Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD)
Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO)
Transcatheter aortic valve implantation (TAVI) is an established treatment for severe aortic stenosis. Despite improved procedural outcomes, neurocognitive complications such as postoperative delirium (POD) and postoperative…
- Conditions
- Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders
- Trial name
- HVU-NEURO (NCT07626567)
- Volunteers
- 500 people
- Sponsor
- Heart and Brain Research Group, Germany