Clinical trials: Postoperative Cognitive Dysfunction(POCD)
Postoperative Cognitive Dysfunction (POCD), Cognitive Change
Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
The goal of this observational study is to explore early cognitive changes in patients aged 70 years or older undergoing same-day discharge after hip or knee replacement surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty
- Trial name
- NCT07598552
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Post Operative Cognitive Dysfunction
Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients
This study will recruit patients more than 65 years old eligible for non-cardiac surgery. Patients who participate will take either vitamin B12 and folic acid supplementation or placebo for 7 days before surgery.
- Trial name
- B12-POCD (NCT03485404)
- Testing
- methylcobalamin, Folic Acid, non-cardiac surgery
- Where
- 13 sites in China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Postoperative Cognitive Dysfunction
POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.
- Trial name
- NCT03084393
- Where
- China
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Postoperative Cognitive Dysfunction, Postoperative Delirium
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Chronic Post Operative Pain
- Trial name
- NCT05439707
- Testing
- transaricular vagus nerve stimulation, fake transaricular vagus nerve stimulation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xuzhou Central Hospital
Postoperative Cognitive Dysfunction
Transcutaneous Electrical Acupoint Stimulation for Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction (POCD) is one of the common complications of cancer patients after operation with a 8.9%-46.1% incidence, which severely affecting patients' postoperative recovery, increasing the medical cost…
- Trial name
- NCT04606888
- Testing
- Transcutaneous electrical acupoint stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Postoperative Cognitive Dysfunction
LINC01844 as a Diagnostic Biomarker for POCD in Elderly Patients
Postoperative cognitive dysfunction (POCD) is a common complication after surgery that is associated with more adverse events and death.
- Trial name
- NCT06387836
- Testing
- Isoflurane 0.8 MAC, Desflurane 0.8MAC
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium - Postoperative, Delirium and Post-operative Cognitive Dysfunction (POCD)
Audio-Recorded Messages Delivered Via iPad to Prevent Delirium in Hip Fracture Patients
The goal of this pilot clinical trial is to learn if personalized audio-recorded reorientation messages can be successfully implemented in general hospital wards for elderly patients after hip fracture surgery.
- Conditions
- Delirium - Postoperative, Delirium and Post-operative Cognitive Dysfunction (POCD), Delirium, Postoperative
- Trial name
- NCT07396532
- Testing
- Audio-Recorded Reorientation Intervention
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Postoperative Cognitive Function
Comparison of Neuroprotection by Propofol and Desflurane for POCD Following Subarachnoid Hemorrhage Surgery
Aneurysmal subarachnoid hemorrhage (aSAH) is characterized by the rupture of an intracranial aneurysm and accumulation of blood in the subarachnoid space with 30 to 40% mortality rate.
- Trial name
- NCT02987218
- Testing
- Propofol, Desflurane
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Postoperative Delirium (POD)
Validation of a Risk Assessment Model for Postoperative Delirium Based on Artificial Intelligence
Postoperative delirium (POD) is a frequent postoperative complication in the elderly, characterised by fluctuating disturbances in attention, awareness, and cognition.
- Trial name
- NCT05639348
- Testing
- Data collection on POD for calculation of the PIPRA score
- Where
- 3 sites in Switzerland
- Volunteers
- 993 people
- Sponsor
- University Hospital, Basel, Switzerland
Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced
Efficiency of Donepezil in Elderly Patients for Prevention of POCD Dysfunction
Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved.
- Conditions
- Total Knee Arthroplasty, Fracture of Head of Femur Articular Displaced, Protrusion of Intervertebral Disc
- Trial name
- NCT04423276
- Testing
- Donepezil
- Where
- China
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Postoperative Complications
Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome
The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
- Trial name
- NCT02766062
- Testing
- metabolic syndrome
- Volunteers
- 94 people
- Sponsor
- General Hospital of Ningxia Medical University
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Postoperative Cognitive Dysfunction, POCD
Optimizing Postoperative Cognition the Elderly
This study will recruit surgical patients more than 65 years old. Patients who participate will wear a sticker on their forehead during surgery which monitors their brain waves (electroencephalogram, EEG) and participate in…
- Trial name
- NCT02650687
- Testing
- Processed EEG
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Dysfunction
Effect of Intraoperative Dexmedetomidine on Early Postoperative Cognitive Dysfunction
This study will aim to identify the impact of Intraoperative dexmedetomidine infusion on POCD assessed by the Montreal Cognitive Assessment (MoCA) in geriatric patients above 60 years undergoing hip surgery under spinal…
- Trial name
- NCT03793751
- Testing
- Dexmedetomidine Injection
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tata Main Hospital
Neurocognitive Disorder, Dexmedetomidine Infusion
Effects of Dexmedetomidine on Postoperative Neurocognitive Disorder
This prospective study involves assessing neurocognitive function in patients undergoing laparotomic gastrointestinal surgery. Mini Mental state Assessment test and Mini-Cog tests will be conducted at multiple intervals…
- Conditions
- Neurocognitive Disorder, Dexmedetomidine Infusion, Postoperative Cognitive Dysfunction, Postoperative Cognitive Dysfunction(POCD)
- Trial name
- NCT06689137
- Testing
- mini mental state assessment test, mini-cog test
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Haseki Training and Research Hospital
Postoperative Cognitive Deficit (POCD), Neurocognitive Disorders
International Observational Study on Perioperative Cognitive Trajectories (POCD Census International/PCI)
The purpose of this international, multi-centre observational study is to describe perioperative cognitive changes (pre-existing neurocognitive disorder [NCD], postoperative delirium [POD] and Postoperative Cognitive Dysfunction…
- Trial name
- NCT03540433
- Where
- 3 sites in Germany
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Perioperative Care
Improvement of Perioperative Care of Elderly Patients
The focus of this study is the development of a perioperative treatment concept for elderly patients, based on individual necessities and risk factors, aiming to improve patient outcome.
- Trial name
- PeriAge (NCT03325413)
- Testing
- Systematic inclusion of family members, Preoperative information, Physical and breathing exercises
- Where
- Germany
- Volunteers
- 310 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sevoflurane, Propofol
Sevoflurane, Propofol and Desflurane on POD/POCD
The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and…
- Conditions
- Sevoflurane, Propofol, Desflurane
- Trial name
- NCT03326960
- Testing
- Sevoflurane, Propofol, Desflurane
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Postoperative Cognitive Dysfunction, Postoperative Pain, Acute
Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD
This study will examine the effect of intraoperative sedation with midazolam, propofol and dexemdetomidine on the occurrence of postoperative cognitive impairment in patients undergoing surgical treatment of pertrochanteric…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric Fracture
- Trial name
- ProDex-POCD (NCT05398757)
- Testing
- Mini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS)
- Where
- Croatia
- Sponsor
- Osijek University Hospital
Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances
TEAS on Sleep Quality and POCD in Elderly Patients
Elderly patients are often considered as a high-risk population for major abdominal surgery due to reduced functional reserve and increased comorbidities.
- Conditions
- Transcutaneous Electrical Acupoint Stimulation, Postoperative Sleep Disturbances, Postoperative Cognitive Dysfunction, Elderly Patients
- Trial name
- NCT04850196
- Testing
- TEAS, control group
- Volunteers
- 100 people
- Sponsor
- Shengjing Hospital