Clinical trials: Postoperative Cognitive Dysfunction
Pain, Postoperative
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery.
- Trial name
- NCT03577730
- Testing
- Caffeine Citrate, Dextrose Water
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Michigan
Postoperative Cognitive Dysfunction
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
The purpose of this study is to determine whether epidural levobupivacaine applied for the purpose of post-operative analgesia compared to systemic analgesia with morphine leads to better pain control, stronger suppression of the…
- Trial name
- NCT02848599
- Testing
- morphine, levobupivacaine
- Where
- Croatia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Delirium, Cognitive Impairment
Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
The purpose of this study is to investigate the effectiveness of a preventative low-dose of Haloperidol to prevent delirium in patients undergoing a esophagectomy, pneumonectomy or thoracotomy.
- Conditions
- Delirium, Cognitive Impairment, Post-traumatic Stress Disorder, Depression
- Trial name
- PE-POD (NCT02213900)
- Testing
- Haloperidol
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Indiana University
Postoperative Complications, Memory Disorders
A Study to Determine if Carbon Dioxide Lavage During Total Knee Surgery Reduces Intraoperative Embolic Events
The purpose of this study is to determine if the use of a carbon dioxide lavage device (CarboJet) to clean bone surfaces during total knee surgery decreases intraoperative embolic events when compared with standard orthopedic…
- Trial name
- NCT00736125
- Testing
- pulsatile saline lavage, carbon dioxide lavage
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kinamed Incorporated
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Delirium, PD
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium comes from a study underway…
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00455143
- Testing
- Precedex (Dexmedetomidine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Post Operative Cognitive Dysfunction
Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Post-operative cognitive dysfunction (POCD) is a common concern for aging patients undergoing elective orthopedic surgery and significantly effects health outcomes.
- Trial name
- POCD (NCT04267328)
- Testing
- Elective Orthopedic Surgery
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- HealthPartners Institute
Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders
Ramelteon in the Prevention of Post-operative Delirium
This trial focuses on a Phase II randomized masked clinical trial testing the effectiveness and safety of peri-operative administration of ramelteon, a melatonin agonist in the prevention of postoperative delirium.
- Conditions
- Delirium, Delirium, Dementia, Amnestic, Cognitive Disorders, Delayed Emergence From Anesthesia, Cognitive Disorders
- Trial name
- RECOVER (NCT02324153)
- Testing
- Ramelteon, Microcrystalline Cellulose, Riboflavin 100 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Alzheimers Disease, Postoperative Delirium
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal…
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Trial name
- MADCO-PC (NCT01993836)
- Testing
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Duke University