Clinical trials: Postoperative Cognitive Dysfunction, open to volunteers
Mild Cognitive Impairment (MCI), Opioid Use
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
Mild cognitive impairment (MCI) affects a substantial proportion of older adults undergoing major surgery and may alter pain processing, pain experience, and opioid use after surgery.
- Conditions
- Mild Cognitive Impairment (MCI), Opioid Use, Cognitive Dysfunction, Postoperative Pain
- Trial name
- NCT07885085
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Miklos Kertai
Post Operative Delerium, Post Operative Cognitive Dysfunction
Eye Movements to Predict Post-Operative Delirium
Postoperative delirium (POD) is a common complication in older adults undergoing surgery, lacking objective and noninvasive diagnostic methods.
- Trial name
- EYE-POD (NCT07806487)
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Postoperative Delirium, Postoperative Cognitive Dysfunction
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
- Conditions
- Postoperative Delirium, Postoperative Cognitive Dysfunction, Thoracic Aortic Aneurysm
- Trial name
- TURBO (NCT04523909)
- Testing
- Trajectory of neuroinflammatory proteins in CSF and blood
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Older Patients, Cognitive Impairment
Repetitive Transcranial Magnetic Stimulation and Postoperative Neurocognitive Recovery
Patients with preoperative cognitive impairment are at increased risks of delayed neurocognitive recovery (DNR) and postoperative neurocognitive disorder (POCD).
- Conditions
- Older Patients, Cognitive Impairment, Repetitive Transcranial Magnetic Stimulation, Delayed Neurocognitive Recovery
- Trial name
- NCT06482749
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 3 sites in China
- Volunteers
- 568 people
- Sponsor
- Peking University First Hospital
Remimazolam Besylate, Thoracoscopic Lobectomy
The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy
Background: During thoracoscopic lobectomy in elderly patients, one-lung ventilation (OLV) is a common procedure. However, this process is prone to cause hypoxemia and postoperative cognitive dysfunction (POCD), which seriously…
- Conditions
- Remimazolam Besylate, Thoracoscopic Lobectomy, Oxygenation, Postoperative Cognitive Dysfunction
- Trial name
- NCT07086911
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jinqiao Qian
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
POCD - Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive-related Adverse Reactions and Brain Metabolomic Characteristics in Elderly Patients
Postoperative cognitive dysfunction (POCD) refers to the difficulties of orientation, cognition, communication, memory and abstract thinking of patients after anesthesia and surgery.
- Trial name
- NCT05555693
- Testing
- Collecting clinical data, EGG，Brain Metabolomic Characteristics(with Magnetic Resonance Spectroscopy), blood gas data and blood sample
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder
The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery
RATIONALE: Postoperative cognitive changes are common after cardiac surgery and can be categorised into three main types: postoperative delirium (POD), delayed neurocognitive recovery (DNCR) and postoperative neurocognitive…
- Conditions
- Postoperative Neurocognitive Dysfunction, Postoperative Neurocognitive Disorder, Cardiac Surgery, Major Surgery Under General Anesthesia
- Trial name
- INOCS (NCT07200726)
- Testing
- Observational study design - no intervention
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Ziekenhuis Oost-Limburg
Frailty, Cognitive Impairment
Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic
This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total…
- Conditions
- Frailty, Cognitive Impairment, Older Adults, Hip Arthroplasty
- Trial name
- ORTOPODCZ (NCT07432009)
- Where
- 7 sites in Czechia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Postoperative Cognitive Disorders
Impact of Combined PSi + NIRS Monitoring in the Prevention of Postoperative Cognitive Disorders in Cardiac Surgery.
Advances in cardiac medicine and anesthesia have made it possible to expand the indications for open heart surgery to increasingly older and more complex patients.
- Trial name
- NCT07267416
- Testing
- NIRS (Near Infrared Spectroscopy), SedLine®
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Brugmann University Hospital
Delirium, Postoperative, Anesthesia
Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery
The goal of this clinical trial (Balanced-2 study) is to compare light to deep general anesthesia using widely available brain monitors, to see if 'light' anesthesia could reduce rates of delirium, cognitive decline, and…
- Conditions
- Delirium, Postoperative, Anesthesia, Surgery-Complications, Cognition Disorder
- Trial name
- Balanced-2 (NCT06268080)
- Testing
- Depth of anesthesia titration using pEEG
- Where
- 3 sites in New Zealand
- Volunteers
- 2,766 people
- Sponsor
- Auckland City Hospital
Cognitive Impairment, Cognitive Impairment, Mild
Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk
Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a…
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Cognitive Impairment, Progressive, Anesthesia
- Trial name
- CAPSULAR (NCT07470216)
- Testing
- Montreal Cognitive Assessment, biomarkers
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Postoperative Cognitive Dysfunction
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor
Postoperative cognitive dysfunction(POCD). is a central nervous system complication in cancer patients with a 8.9-46.1% incidence.
- Trial name
- TEAS (NCT05482477)
- Testing
- Transcutaneous acupoint electrical stimulation
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Postoperative Cognitive Dysfunction, Postoperative Recovery
Older People's Neurocognitive Recovery After Cardiac Surgery
Society is aging and advantages in anesthesia and surgery allow more complex interventions in older persons. Old age is a significant risk factor for the development of postoperative neurocognitive decline characterized by a…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Recovery, Cardiac Surgery
- Trial name
- ECPON (NCT06469515)
- Testing
- Elective or urgent cardiac surgery
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Karolinska Institutet
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Postoperative Cognitive Dysfunction (POCD)
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery.
- Trial name
- OPCAB-POCD (NCT07643194)
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability
Predicting Postoperative Delirium With Heart Rate Variability Obtained by Analgesia Nociception Index
The aim of this pilot study is to establish a correlation between perioperative heart rate variability (HRV) as an expression of the shift in the balance of the autonomic nervous system and the occurrence of postoperative…
- Conditions
- POSTOPERATIVE DELIRIUM AND POSTOPERATIVE COGNITIVE DECLINE, Heart Rate Variability, Biomarkers
- Trial name
- DANI (NCT06709482)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Postoperative Delirium (POD)
Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery
Postoperative delirium (POD) is a common and serious neurocognitive complication after surgery, particularly in elderly patients undergoing major cancer surgeries.
- Trial name
- NCT07627906
- Testing
- Group ketofol, Group ketodex, Group Control
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Cairo University
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University