Clinical trials: Postoperative Cognitive Dysfunction (POCD)
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Postoperative Cognitive Dysfunction
To Study the Effect of Sevoflurane and Propofol V Sevoflurane and Dexmedetomidine on Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction (POCD), is a subtle decline in cognitive function characterized by impairment of memory and reduced ability to concentrate in elderly patients exposed to general anaesthesia.
- Trial name
- POCD (NCT03145714)
- Testing
- Maintainance of anesthesia with Intravenous Propofol infusion, Maintainance of anesthesia with Intravenous Dexmedetomidine
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Post Operative Cognitive Dysfunction
Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients
This study will recruit patients more than 65 years old eligible for non-cardiac surgery. Patients who participate will take either vitamin B12 and folic acid supplementation or placebo for 7 days before surgery.
- Trial name
- B12-POCD (NCT03485404)
- Testing
- methylcobalamin, Folic Acid, non-cardiac surgery
- Where
- 13 sites in China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Postoperative Cognitive Dysfunction
Risk Factors for Early POCD in the Patients With PSM Undergoing CRS-HIPEC
Objectives to investigate the incidence and associated factors for early postoperative cognitive dysfunction in the patients with peritoneal surface malignancies undergoing cytoreductive surgery and hyperthermic intraperitoneal…
- Trial name
- NCT02462564
- Where
- China
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wuhan University
Sevoflurane, Propofol
Sevoflurane, Propofol and Desflurane on POD/POCD
The investigators will perform clinical studies to test the hypothesis that participants who have total hip/knee replacement under sevoflurane, propofol or desflurane anesthesia will have different effects on the incidence and…
- Conditions
- Sevoflurane, Propofol, Desflurane
- Trial name
- NCT03326960
- Testing
- Sevoflurane, Propofol, Desflurane
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Postoperative Cognitive Dysfunction, Postoperative Delirium
Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) occur in 11-51% of patients after surgery, and its prevalence increases with age.
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Chronic Post Operative Pain
- Trial name
- NCT05439707
- Testing
- transaricular vagus nerve stimulation, fake transaricular vagus nerve stimulation
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Xuzhou Central Hospital
Ischemic Attack, Transient
Does Positioning Effects on Early Postoperative Cognitive Dysfunction in Laparoscopic Oncological Surgery
Laparoscopic surgery is an alternative to open surgical techniques for reasons such as less blood loss,less need for transfusion, shorter discharge time.
- Trial name
- NCT04714346
- Testing
- no interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function
Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients
This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery.
- Conditions
- Postoperative Cognitive Dysfunction (POCD), Neurocognitive Function, Sedation and Analgesia, Geriatric Patients
- Trial name
- TCI-NEURO (NCT07311447)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namigar Turgut
Cognitive Dysfunction
Effect of Intraoperative Dexmedetomidine on Early Postoperative Cognitive Dysfunction
This study will aim to identify the impact of Intraoperative dexmedetomidine infusion on POCD assessed by the Montreal Cognitive Assessment (MoCA) in geriatric patients above 60 years undergoing hip surgery under spinal…
- Trial name
- NCT03793751
- Testing
- Dexmedetomidine Injection
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Tata Main Hospital
Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder
POCD After Major Gynecologic Surgery
This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery.
- Trial name
- POCD-GYN (NCT07589348)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Fatihhan Zeytun
Postoperative Cognitive Dysfunction, Postoperative Delirium
Ulinastatin Improves Post-Cardiac Surgery Cognitive Dysfunction
The study comprised two primary components: a retrospective analysis of clinical big data and a conventional prospective cohort study involving patients undergoing cardiac surgery. The objectives were: 1.
- Trial name
- NCT06268249
- Testing
- Ulinastatin
- Where
- China
- Volunteers
- 7,065 people
- Sponsor
- Qin Zhang
Postoperative Cognitive Dysfunction
Assessment of POCD After Steep Trendelenburg Position and CO2 Pneumoperitoneum With Cerebral Oxygen
Postoperative cognitive decline (POCD) is a common and impactful outcome of surgical procedures in older adults. The pathophysiology and causative mechanisms for POCD are poorly understood.
- Trial name
- NCT03372135
- Where
- China
- Volunteers
- 147 people
- Sponsor
- RenJi Hospital
Cardiac Surgery Patients
Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)
The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD
- Trial name
- NCT02084030
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Postoperative Cognitive Dysfunction, Delirium
Peri-Anesthetic Imaging of Cognitive Dysfunction
Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the…
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia, Neurotoxicity
- Trial name
- PAICOD (NCT01322672)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Postoperative Cognitive Dysfunction, Postoperative Pain, Acute
Propofol and Dexmedetomidin vs Midazolam Intraoperative Sedation and POCD
This study will examine the effect of intraoperative sedation with midazolam, propofol and dexemdetomidine on the occurrence of postoperative cognitive impairment in patients undergoing surgical treatment of pertrochanteric…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Pain, Acute, Pertrochanteric Fracture
- Trial name
- ProDex-POCD (NCT05398757)
- Testing
- Mini mental state exame (MMSE), Digit Symbol Substitution Test (DSST), Numeric rating Scale (NRS)
- Where
- Croatia
- Sponsor
- Osijek University Hospital
Postoperative Delirium, PD
Cognitive Protection - Dexmedetomidine and Cognitive Reserve
This is a pilot study to evaluate the effect of dexmedetomidine in the prevention of delirium in non-cardiac surgical patients. The preliminary data regarding the effect of dexmedetomidine on delirium comes from a study underway…
- Conditions
- Postoperative Delirium, PD, Postoperative Cognitive Dysfunction, POCD
- Trial name
- NCT00455143
- Testing
- Precedex (Dexmedetomidine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Post-operative Delirium, Post-operative Cognitive Dysfunction
Risk Communication About Post-operative Delirium (POD) and Post-operative Cognitive Dysfunction (POCD)
The purpose of this study is to assess the awareness of post-operative delirium (POD) and post-operative cognitive dysfunction (POCD), their respective risk factors and effective preparation and treatment options in a…
- Trial name
- NCT03953313
- Where
- Germany
- Volunteers
- 223 people
- Sponsor
- Charite University, Berlin, Germany
1. Postoperative Cognitive Dysfunction
POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia
The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's…
- Trial name
- NCT01199913
- Testing
- The intervention will be Mini-Mental Status Examination (MMSE)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Postoperative Complications, Delayed Emergence From Anesthesia
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms.
- Conditions
- Postoperative Complications, Delayed Emergence From Anesthesia, Cognitive Dysfunction
- Trial name
- NCT04529304
- Testing
- Bilateral Bispectral Index and EEG
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital