Clinical trials: Postoperative Delirium (POD)
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Gastroesophageal Cancer (GC), Postoperative Delirium (POD)
Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer
The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery.
- Conditions
- Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
- Trial name
- CASE (NCT06687291)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska Institutet
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Coronary Artery Disease, Sleep Quality
Effect of Eye Mask Use on Sleep Quality and Delirium After CABG Surgery
Coronary artery bypass graft (CABG) surgery is an effective treatment for coronary artery disease; however, sleep disturbances and delirium are common during the postoperative period and may adversely affect recovery.
- Conditions
- Coronary Artery Disease, Sleep Quality, Postoperative Delirium (POD)
- Trial name
- EYE-CABG (NCT07768020)
- Testing
- Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Munzur University
Postoperative Delirium (POD)
The Study of Postoperative Delirium and Glymphatic System Function in Cardiac Surgery
Postoperative delirium after cardiac surgery is an acute cerebral dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances.
- Trial name
- Delirium (NCT06901479)
- Testing
- Blood was drawn for proteomics testing and Magnetic Resonance Imaging.
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Postoperative Delirium
Digitalized Clinical Decision Support for the Prevention of Postoperative Delirium (POD)
The project aims to improve patient safety, reduce barriers to the implementation of current guideline recommendations, reduce workload in clinics, increase efficiency in work processes and close gaps in care.
- Trial name
- NCT06445153
- Testing
- Intervention with clinical decision support system
- Where
- 4 sites in Germany
- Volunteers
- 844 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Delirium
Whether Opioids Are Factor That Induced POD?
The purpose of this study was to investigate whether perioperative use of low doses of opioids could reduce postoperative delirium .
- Trial name
- POD (NCT05596071)
- Testing
- Sufentanil Citrate, Ropivacaine 0.75% Injectable Solution, Epidural catheter
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Zhejiang Cancer Hospital
Postoperative Delirium (POD), Postoperative Pain
Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery
This study aims to investigate the effect of target-controlled infusion using the Eleveld pharmacokinetic model compared with manually controlled total intravenous anesthesia on the incidence of postoperative delirium in patients…
- Conditions
- Postoperative Delirium (POD), Postoperative Pain, PONV, Burst Suppression
- Trial name
- NCT07357480
- Testing
- Target Controlled Infusion, Total Intravenous Anesthesia(TIVA)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Istanbul University - Cerrahpasa
Intraoperative, Venous Congestion
Venous Congestion And Delirium After Cardiac Surgery
Postoperative delirium (POD) is an acute brain dysfunction characterized by inattention, impaired consciousness, and cognitive and orientation disturbances, and is a common complication after cardiac surgery.
- Conditions
- Intraoperative, Venous Congestion, Postoperative Delirium (POD), Cardiac Surgery
- Trial name
- NCT07285187
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters, POD assessments
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhuan Zhang
Geriatric Patient Care Improvement, Postoperative Delirium (POD)
The Effects of Anesthesia Depth Monitoring on Postoperative Recovery and Cognitive Functions in the Geriatric Patient Population
This study will be conducted on patients aged 65 and older scheduled for surgery due to lumbar or cervical disc herniation. General anesthesia is routinely used for these types of surgeries in the hospital.
- Conditions
- Geriatric Patient Care Improvement, Postoperative Delirium (POD), Burst Suppression
- Trial name
- NCT06844279
- Testing
- Control Group: Standard Hemodynamic Monitoring, Processed Electroencephalogram (BIS Index), Processed Electroencephalogram (DSA Mode)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Aslıhan Güleç
Cognitive Dysfunction
Association Between qEEG Measure and Post-Operative Cognitive Dysfunction (POCD) and Postoperative Delirium (POD)
Cognitive complications after major surgery are a common phenomenon. The incidence of Postoperative Cognitive Dysfunction (POCD), may vary from 5% to 25% in adult patients, depending on different risk factors.
- Trial name
- NCT03977350
- Testing
- EEG monitoring
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Neuroindex Ltd.
Regional Anaesthesia, Postoperative Delirium (POD)
Association of Transversus Abdominis Plane Block (TAPB) with Postoperative Delirium (POD) in Elderly Patients Undergoing Major Gastrointestinal Surgery
Postoperative delirium can increase postoperative adverse reactions and prognosis in elderly patients undergoing gastrointestinal surgery.
- Conditions
- Regional Anaesthesia, Postoperative Delirium (POD), Transversus Abdominis Plane Block (TAP Block)
- Trial name
- NCT06829108
- Volunteers
- 5,220 people
- Sponsor
- Chinese PLA General Hospital
Delirium - Postoperative
Effectiveness of Electroencephalography Guided Anesthesia
This study will use brain wave information, known as electroencephalography (EEG), to help guide anesthesia delivery during surgery.
- Trial name
- EEG Anesthesia (NCT07567729)
- Testing
- EEG-guided anesthesia training program for anesthesia providers, EEG-Guided Intervention
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Stanford University
Postoperative Delirium (POD)
The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study
Glucocorticoids can be used to inhibit postoperative systemic inflammatory response syndrome. They may reduce the risk of major complications and mortality.
- Trial name
- NCT07271394
- Testing
- Administration of methylprednisolone sodium succinate during general anesthesia induction, No administration of methylprednisolone sodium succinate during general anesthesia induction
- Where
- China
- Volunteers
- 25,800 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Delirium (POD)
Dexmedetomidine Nasal Spray on Postoperative Delirium in Elderly Thoracoscopic Lung Resection Patients
This clinical trial is designed to observe the effect of dexmedetomidine nasal spray on the incidence of postoperative delirium in elderly patients undergoing thoracoscopic lung resection.
- Trial name
- NCT07579806
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Postoperative Delirium (POD), Cardiopulmonary Bypass
Effect of Low Tidal Volume Ventilation on Postoperative Delirium
This study aims to evaluate the effect of low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) on postoperative delirium.
- Conditions
- Postoperative Delirium (POD), Cardiopulmonary Bypass, Low Tidal Volume Ventilation, Cognitive Dysfunction, Postoperative
- Trial name
- CLEVER (NCT06752421)
- Testing
- Group B: Low tidal volume
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Nevsehir Public Hospital
Postoperative Delirium (POD), Peripheral Arterial Disease
Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention
This randomized controlled trial will evaluate whether preoperative ultrasound-guided stellate ganglion block reduces the incidence of postoperative delirium in adults aged 60 years or older undergoing elective peripheral…
- Trial name
- NCT07848113
- Testing
- ropivacaine
- Volunteers
- 168 people
- Sponsor
- Assiut University
Postoperative Delirium (POD), Cerebral Small Vessel Diseases
Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac Surgery
This clinical study investigates whether virtual reality (VR)-based cognitive training can help prevent postoperative delirium (POD) in elderly non-cardiac patients with pre-existing cerebral small vessel disease (CSVD).
- Trial name
- NCT06999668
- Testing
- Virtual reality cognitive function training, Virtual scene intervention
- Where
- 2 sites in China
- Volunteers
- 416 people
- Sponsor
- Peking University Third Hospital
Delirium
Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Many individuals experience an acute change in thinking and reasoning skills after surgery. This is called post-operative delirium (PD). PD symptoms typically start 1-3 days after surgery.
- Trial name
- NCT02230605
- Testing
- Mini-Mental State Examination, Self-Administered Gerocognitive Examination, Geriatric Depression Scale
- Where
- United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Colorectal Cancer (MSI-H), Postoperative Delirium (POD)
POD Risk for Colorectal Cancer Surgery
Postoperative delirium is a common complication after colorectal cancer surgery that hinders recovery. This observational study hypothesizes that a simple, practical risk tool can be developed by combining preoperative clinical…
- Trial name
- NCT07597330
- Where
- China
- Volunteers
- 590 people
- Sponsor
- LanZhou University