Clinical trials: Postoperative Disease Recurrence
Gut Microbiota, Oral Microbiota
The Relationship Between Postoperative Changes of Oral and Intestinal Flora and Prognosis
Specific oral microbiome has been found to contribute to the development of colorectal cancer. We speculate that specific oral microbiota related to colorectal cancer relapse after curative treatment.
- Conditions
- Gut Microbiota, Oral Microbiota, Colorectal Cancer
- Trial name
- NCT03667495
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Colorectal Cancer, Metastatic Cancer
Floxuridine, Dexamethasone, and Irinotecan After Surgery in Treating Patients With Liver Metastases From Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as floxuridine, dexamethasone, and irinotecan, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003753
- Testing
- dexamethasone, floxuridine, irinotecan hydrochloride
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sacrococcygeal Pilonidal Sinus Disease, Pilonidal Sinus Disease
LASER VERSUS CRYSTALLIZED PHENOL IN PILONIDAL SINUS DISEASE
This single-center prospective randomized parallel-group trial compares laser ablation and crystallized phenol application in adults with primary uncomplicated sacrococcygeal pilonidal sinus disease.
- Trial name
- PSD-L-F (NCT07701772)
- Testing
- Laser Ablation, Crystallized phenol application
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Sanliurfa Education and Research Hospital
Radiotherapy, Immunotherapy
Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With High Risk of Locally Recurrence
This study is a randomized controlled phase II trial to evaluate the efficacy of the combination of stereotactic body radiation therapy (SBRT) and immunotherapy with postoperative chemotherapy in colorectal cancer liver…
- Conditions
- Radiotherapy, Immunotherapy, Liver Metastases, Colorectal Cancer
- Trial name
- IMPROVE (NCT06120127)
- Testing
- SBRT, Chemotherapy, PD-1 antibody
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Breast Cancer
IRB-HSR# 13957: IV Lidocaine for Patients Undergoing Primary Breast Cancer Surgery:
The purpose of this study is to determine whether a local anesthetic drug (lidocaine) given during anesthesia intravenously (IV) through a needle in your vein,), can: 1. Help decrease pain after surgery. 2.
- Trial name
- NCT01204242
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Virginia
Malignant Glioma, Glioblastoma Multiforme
Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma
The experimental anti-cancer drug IL13-PE38QQR, which is being developed for the treatment of malignant brain tumors, is composed of parts of two proteins: the immune system cytokine IL13 and a toxin from the bacterium…
- Conditions
- Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
- Trial name
- NCT00064779
- Testing
- IL13-PE38QQR, targeted fusion protein therapy, surgery
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- INSYS Therapeutics Inc
Sarcopenia, Sarcopenic Obesity
Effects of Sarcopenia and Sarcopenic Obesity in Complex Abdominal Wall Surgery
The objective of our study is to evaluate the prevalence of sarcopenia and sarcopenic obesity in our surgical population and their relationship in postoperative complications after complex abdominal wall surgery and its influence…
- Conditions
- Sarcopenia, Sarcopenic Obesity, Incisional Hernia
- Trial name
- NCT04690179
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Anxiety Postoperative, Patient Non-Compliance
Psychological and Physical Distress and Care Needs in Operable Lung Cancer Patients Receiving Surgery
The lung cancer is the most has the life minacity in all kinds of cancers, and it also remains the most common cause of cancer-related death in the world.
- Conditions
- Anxiety Postoperative, Patient Non-Compliance, Psychological Distress
- Trial name
- NCT01362842
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Secondary Hyperparathyroidism
Comparison of Total Parathyroidectomy With and Without Autotransplantation
The purpose of this study is to compare short-term and long-term efficacy of total parathyroidectomy with autotransplantation and total parathyroidectomy without autotransplantation for Secondary hyperparathyroidism.
- Trial name
- NCT02536287
- Testing
- total PTX without autotransplantation, total PTX with autotransplantation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The Second Hospital of Anhui Medical University
Colorectal Cancer
Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug, giving the drugs in different ways, and combining chemotherapy with radiation…
- Trial name
- NCT00002896
- Testing
- chemotherapy, fluorouracil, leucovorin calcium
- Where
- Italy
- Volunteers
- 774 people
- Sponsor
- European Institute of Oncology
Physical Function, Pain
Polypropylene Mesh Versus Polytetrafluoroethylene (PTFE) Mesh in Inguinal Hernia Repair
To evaluate the safety and efficacy of the Lichtenstein's hernioplasty using Infinit® PTFE Mesh, and to compare it with the traditional Lichtenstein procedure performed with polypropylene mesh.
- Conditions
- Physical Function, Pain, Hernia, Wound Infection
- Trial name
- NCT01141335
- Testing
- polypropylene mesh, Infinit® PTFE mesh (WL Gore)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Roma La Sapienza
Gastric Cancer
Apatinib as Maintenance Therapy After First-line Chemotherapy(DC for 4 Cycles) in Postoperative Recurrence/Metastasis Progressive Gastric Cancer
The purpose of this study is to assess the efficacy and safety of apatinib as maintenance therapy after first-line chemotherapy in Postoperative Recurrence / Metastasis Progressive Gastric Cancer.
- Trial name
- NCT02509806
- Testing
- Apatinib
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Hebei Medical University
Breast Cancer, Colorectal Cancer
Immunotherapy After Surgery in Treating Patients With Breast Cancer, Colon Cancer, or Melanoma
RATIONALE: Immunotherapy uses different ways to stimulate the immune system and stop cancer cells from growing. Immunotherapy biological extracts may be useful as adjuvant therapy in treating patients who have had surgery for…
- Conditions
- Breast Cancer, Colorectal Cancer, Melanoma (Skin)
- Trial name
- NCT00002455
- Testing
- Corynebacterium granulosum P40, adjuvant therapy
- Where
- Argentina
- Sponsor
- Centro Oncologico de Excelencia
Kidney Cancer
Sunitinib Before and After Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed By Surgery
RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00747305
- Testing
- sunitinib malate, gene expression analysis, reverse transcriptase-polymerase chain reaction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Harry Drabkin
Colon Adenocarcinoma, Stage I Colon Cancer
Postoperative Circulating Tumor DNA Monitoring in Stage I-III Driver-Mutant Colon Adenocarcinoma
This multicenter prospective observational cohort study will enroll 392 patients with stage I-III colon adenocarcinoma who undergo curative resection and whose tumors harbor at least one prespecified oncogenic driver mutation…
- Conditions
- Colon Adenocarcinoma, Stage I Colon Cancer, Stage II Colon Cancer, Stage III Colon Cancer
- Trial name
- ADX-DRIVER-CRC (NCT07795528)
- Testing
- Longitudinal ctDNA-MRD NGS testing at scheduled postoperative time points
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Ruijin Hospital
Non-small Cell Lung Cancer, Minimal Residual Disease
Liquid Biopsy-Based Novel Modality for Postoperative Management of Lung Cancer
The goal of this study is to develop new techniques for minimal residual disease(MRD) monitoring and to confirm the efficacy and safety of MRD-guided postoperative management for early stage non-small cell lung cancer.
- Conditions
- Non-small Cell Lung Cancer, Minimal Residual Disease, Adaptive Treatment
- Trial name
- NCT06930807
- Testing
- Adaptive postoperative management based on minimal residual disease
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University People's Hospital
Colorectal Adenocarcinoma Metastatic in the Liver, Colorectal Cancer
Liver-directed Chemotherapy After Surgery of Liver Metastases of Colorectal Cancer in Patients With High Risk of Recurrence of Their Disease
At the time of diagnosis, 25% of patients with colorectal cancer present with liver metastasis (CRLM). Among patients with localized colorectal cancer (Stages I-III), 50% to 70% will develop liver metastases during the course of…
- Trial name
- PACHA-02 (NCT07284394)
- Testing
- Arterial catheter infusion chemotherapy, IV Chemotherapy (Regimen 1)
- Volunteers
- 272 people
- Sponsor
- UNICANCER
Recurrent Prostate Carcinoma
Gallium Ga 68-labeled PSMA-11 PET/CT and Fluciclovine F18 PET/CT in Imaging Participants With Recurrent Prostate Cancer After Surgery
This phase II trial compares how well gallium 68-labeled PSMA-11 positron emission tomography/computed tomography (PET/CT) works compared to fluciclovine F18 PET/CT in imaging participants with prostate cancer after surgery that…
- Trial name
- PSMA vs AXUMIN (NCT03515577)
- Testing
- Computed Tomography, Fluciclovine F18, Gallium Ga 68-labeled PSMA-11
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Locally Advanced Soft Tissue Sarcoma, Recurrent Soft Tissue Sarcoma
First-in-man Clinical Trial of CEB-01 PLGA Membrane in Recurrent or Locally Advanced Retroperitoneal Soft Tissue Sarcoma
This is an open label, first-in-man clinical trial to assess safety and tolerability of CEB-01 PLGA membrane in patients with recurrent or locally advanced retroperitoneal soft tissue sarcoma after surgery.
- Trial name
- NCT04619056
- Testing
- CEB-01 membrane loaded with SN-38
- Where
- 5 sites in Spain
- Volunteers
- 21 people
- Sponsor
- CEBIOTEX
Colorectal Cancer, Colon Cancer
Factors Affecting the Results of Treatment of Patients With Colorectal Cancer
The study attempts to quantify the relative risks for mortality, anastomotic leakage and other early and late postoperative complications, recurrence rate, cancer-specific survival, recurrence-free survival after colorectal…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancer, Colorectal Adenocarcinoma
- Trial name
- NCT06050447
- Testing
- Right hemicolectomy, Left hemicolectomy, Sigmoid colon resection
- Where
- Russia
- Volunteers
- 1,200 people
- Sponsor
- Immanuel Kant Baltic Federal University