Clinical trials: Postoperative Disease Recurrence
Pain, Postoperative, Breast Cancer
Postoperative Analgesia Impact of Narcotic Free Anesthesia
The first hypothesis of the study is that substituting fentanyl by esmolol and metoprolol during general anesthesia for patients undergoing mastectomy will result in less pain and less narcotic consumption in the recovery room.
- Conditions
- Pain, Postoperative, Breast Cancer, Postoperative Nausea and Vomiting
- Trial name
- PAINFree (NCT01544959)
- Testing
- fentanyl, beta-blocker (esmolol, metropolol)
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- Université de Sherbrooke
FIGO Stage IVA Ovarian Cancer, FIGO Stage IVB Ovarian Cancer
Surgery and Chemotherapy With or Without Chemotherapy After Surgery in Treating Patients With Ovarian, Fallopian Tube, Uterine, or Peritoneal Cancer
This phase I trial studies the side effects and how well surgery and heated chemotherapy with or without non-heated chemotherapy after surgery works in treating patients with ovarian, fallopian tube, uterine, or peritoneal…
- Conditions
- FIGO Stage IVA Ovarian Cancer, FIGO Stage IVB Ovarian Cancer, Platinum-Resistant Ovarian Carcinoma, Recurrent Fallopian Tube Carcinoma
- Trial name
- NCT01970722
- Testing
- Carboplatin, Cisplatin, Gemcitabine Hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- City of Hope Medical Center
Cognitive/Functional Effects, Recurrent Breast Cancer
Vascular and Cognitive Assessments in Patients With Breast Cancer Undergoing Chemotherapy After Surgery
This clinical trial studies vascular and cognitive assessments in patients with breast cancer undergoing chemotherapy after surgery.
- Conditions
- Cognitive/Functional Effects, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT01483196
- Testing
- ultrasound imaging, questionnaire administration, assessment of therapy complications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer
A Pilot Study to Evaluate the Impact of Dexmedetomidine on Breast Cancer Recurrence After Surgery
Dexmedetomidine is widely used as an anaesthetic for general anesthesia during surgery. Previous studies in cells and animals show that dexmedetomidine may promote cancer growth.
- Trial name
- NCT03109990
- Testing
- Dexmedetomidine, Saline
- Where
- China
- Volunteers
- 148 people
- Sponsor
- RenJi Hospital
Melanoma (Skin)
Post-Operative Adjuvant Radiotherapy With Concurrent Interferon-Alfa
RATIONALE: Interferon alfa may interfere with the growth of tumor cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining interferon alfa plus radiation therapy may kill more tumor cells.
- Trial name
- NCT00005615
- Testing
- Interferon alfa, Radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Crohn Disease, Recurrence
Mesentery Guide Identify Microscopic Clean Resection and Reduces Crohn's Endoscopic Recurrence
Microscopic clean margin is associated with reduced endoscopic recurrence after bowel resection for ileocolic Crohn's disease (CD).
- Trial name
- NCT06550843
- Testing
- mesentery-guided division
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Abdominal Hernias and Other Abdominal Wall Conditions, Post-operative Pain
A Study to Evaluate Two Different Surgical Methods for Treatment for Abdominal Wall Diastasis
This is a three armed prospective randomized trial that will compare two different surgical techniques for reconstruction of the abdominal wall diastasis with a conservative treatment procedure.
- Conditions
- Abdominal Hernias and Other Abdominal Wall Conditions, Post-operative Pain, Recurrence
- Trial name
- NCT01586741
- Testing
- Quill suture application for repair or polypropylene mesh
- Where
- Sweden
- Volunteers
- 96 people
- Sponsor
- Karolinska Institutet
Stage III Colorectal Cancer, Colorectal Cancer Liver Metastasis
A Clinical Research of CAR T Cells Targeting CEA Positive Colorectal Cancer (CRC)
The main purpose of this research is to verify the safety of CEA targeted chimeric antigen receptor T cells and to determine the proper dosage of CAR T cells infused.
- Trial name
- CRC (NCT04513431)
- Testing
- Anti-CEA-CAR T
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Breast Cancer
Study on Early Auxiliary Diagnosis and Postoperative Recurrence Monitoring of Breast Cancer
This study screened and identified effective methylation markers in breast cancer, established a detection system for early screening and early diagnosis, and provided a research basis for the embryonic form of non-invasive…
- Trial name
- NCT05858242
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Crohn's Disease
Curcumin Associated With Thiopurin in the Prevention of Post-op Recurrence in Crohn Disease
Curcumin, the active ingredient of turmeric, has been used for long term in the treatment of inflammatory conditions. Inhibition of NF-κB is postulated as the main mechanism responsible for the anti-inflammatory effect of…
- Trial name
- POPCUR (NCT02255370)
- Testing
- Curcumin
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Clermont-Ferrand
Flammatory Bowel Disease, Crohn's Disease
Early Postoperative Recurrence in Crohn's Disease: Predictors of Research Targeting the Constitutional Mutation of IRGM
Crohn's disease is a disease of complex etiology, multifactorial and still poorly understood. This disease, due to its morbidity and mortality, poses a significant public health problem in France.
- Trial name
- NCT01663142
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Crohn Disease
Effectiveness of Rifaximin on Preventing Postoperative Recurrence in Crohn's Disease
Some studies have shown that rifaximin is effective in the management of Crohn's Disease. Meanwhile, its adverse effect is tolerable. But no study has been conducted to assess its effect on preventing postoperative recurrence.
- Trial name
- NCT03185624
- Testing
- Rifaximin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma
Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
This randomized phase III trial studies carboplatin, paclitaxel and gemcitabine hydrochloride when given together with or without bevacizumab after surgery to see how well it works in treating patients with ovarian, epithelial…
- Conditions
- Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma
- Trial name
- NCT00565851
- Testing
- Bevacizumab, Carboplatin, Docetaxel
- Where
- 709 sites in United States, Japan and 1 more
- Volunteers
- 1,052 people
- Sponsor
- National Cancer Institute (NCI)
Relapse, Quality of Life
Ingrown Toenails : Surgery Only Versus Surgery + Chemical Cauterization With TCA
Ingrown toenail is a very common disease in the general population that touches young adults. There are lots of treatments from local care of pedicure to surgery with matricectomy.
- Conditions
- Relapse, Quality of Life, Complication, Pain, Postoperative
- Trial name
- NCT04921540
- Testing
- Ingrown toenails with surgery with chemical cauterisation, Ingrown toenails with only surgery
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Chronic Subdural Hematoma, At Risk of Post-operative Recurrence
Embolization of the Middle Meningeal Artery for the Prevention of Chronic Subdural Hematoma Recurrence in High Risk Patients (EMPROTECT)
Standard of care for the management of symptomatic chronic subdural hematomas (SDHs) is neurosurgical burr-hole evacuation followed by drainage. Post-operative recurrence rates may be as high as 10 to 20 %.
- Conditions
- Chronic Subdural Hematoma, At Risk of Post-operative Recurrence, Burr-hole Surgery
- Trial name
- EMPROTECT (NCT04372147)
- Testing
- MMA embolization
- Where
- 12 sites in France
- Volunteers
- 342 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Otitis Media
Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy
The purpose of this study is to compare the difference in effect of three clinically common methods of providing pain medication during surgery for ventilating tubes placed for recurring ear infections.The methods are fentanyl…
- Trial name
- NCT01244126
- Testing
- Intranasal fentanyl, morphine IM, IV morphine
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Baylor College of Medicine
Bladder Cancer
Peptide Vaccine Focusing on Prevention of the Recurrence for Bladder Cancer
The purpose of this study is to evaluate the clinical efficacy for the prevention of the recurrence for bladder cancer after TUR-Bt
- Trial name
- NCT00633204
- Testing
- MPHOSPH1 and DEPDC1
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Iwate Medical University
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors
This pilot clinical trial studies how well electrocorticography works in mapping functional brain areas during surgery in patients with brain tumors.
- Conditions
- Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Brain Neoplasm
- Trial name
- NCT02754544
- Testing
- Direct Electrocortical Stimulation, Electrocorticography
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Glioma, Glioblastoma Multiforme
Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients
IL13-PE38QQR is an oncology drug product consisting of IL13 (interleukin-13) and PE38QQR (a bacteria toxin). IL3-PE38QQR is a protein that exhibits cell killing activity against a variety of IL13 receptor-positive tumor cell…
- Conditions
- Malignant Glioma, Glioblastoma Multiforme, Anaplastic Astrocytoma, Mixed Oligoastrocytoma
- Trial name
- NCT00024557
- Testing
- IL13-PE38QQR, targeted fusion protein therapy, surgery
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- INSYS Therapeutics Inc