Clinical trials: Postoperative Disease Recurrence
Rectal Cancer, Organ-Space Surgical Site Infection
Organ/Space Surgical Site Infection and Recurrence and Survival in Rectal Cancer Surgery
In rectal cancer surgery, the organ/space surgical site infection (O/S-SSI) has an impact on patient's prognosis. Its influence in the oncologic outcomes remains controversial.
- Trial name
- VINCat_PDO_2 (NCT06382415)
- Where
- Spain
- Volunteers
- 3,826 people
- Sponsor
- Hospital de Granollers
Crohn's Disease
The Effect of Vitamin D3 to Maintain Surgical Remission in Postoperative Crohn's Disease
The majority of patients with Crohn's disease (CD) need to undergo surgical bowel resection. Postoperative recurrence of the disease is virtually inevitable and continues to be one of the most challenging therapeutic problems in…
- Trial name
- DETECT (NCT02010762)
- Testing
- Vitamin D
- Where
- Netherlands
- Volunteers
- 142 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Endometrioma
Post Operative Continuous Active Combination Sex Steroids for the Prevention of Recurrent Endometrioma Formation
The aim of this study is to determine whether or not continuous combined oral contraceptive pills (COCP's) decrease the risk of recurrent endometrioma formation.
- Trial name
- NCT00999479
- Testing
- Norethindrone acetate and ethinyl estradiol tablets, USP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oklahoma
Breast Cancer
Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the Breast
PURPOSE: This phase II trial studied how well radiation therapy works after surgery in treating women with phyllodes tumor of the breast. RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003404
- Testing
- Adjuvant Radiotherapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Cancer
Evaluation of Prognostic Monitoring for Breast Cancer Patients With Recurrence and Metastasis After Surgery
The relationship between immune inflammation-related protein complexes in blood and recurrence or metastasis of breast cancer with completed standard treatment will be studied.
- Trial name
- NCT04145973
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Quality of Life
Feasibility Study of Lidocaine Infusion During Bowel Cancer Surgery for Cancer Outcome
This feasibility (small) study aims to see if it is possible to run a large study looking at the effect of lidocaine on large bowel cancer recurrence after surgery in the NHS hospitals.
- Conditions
- Colorectal Cancer, Quality of Life, Recurrent Cancer
- Trial name
- FLICOR (NCT05250791)
- Testing
- Lidocaine hydrochloride 2% for injection, 0.9% sterile Sodium Chloride solution for injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Recurrent Ovarian Cancer
Dendritic Cell Vaccination With Standard Postoperative Chemotherapy for the Treatment of Adult Ovarian Cancer
Effective treatments are desperately needed for ovarian cancer patients. This phase I clinical trial assesses the safety of a novel personalized dendritic-cell vaccine administered to ovarian cancer patients.
- Trial name
- NCT05270720
- Testing
- dendritic cell
- Where
- China
- Volunteers
- 9 people
- Sponsor
- West China Second University Hospital
Recurrence, Postoperative Complication
Videoendoscopic Pilonidal Sinus Surgery
This study examines performing pilonidal sinus surgery minimal invasively with videoendoscopic approach.
- Trial name
- videosinus (NCT01583751)
- Testing
- videoendoscopic resection of pilonidal sinus
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- SB Istanbul Education and Research Hospital
Crohn Disease
Management of Moderate POstoperative Recurrence in Crohn's Disease: a randoMizEd contROLled Trial of Therapeutic Escalation, the POMEROL Trial. (POMEROL)
Study type : A 30 months, multicentre, open-label strategic randomized controlled trial Population : Chron's Disease (CD) patients with an i2 endoscopic postoperative recurrence in the year following ileocolonic resection…
- Trial name
- POMEROL (NCT05072782)
- Testing
- Infliximab CT-P13, Immunosuppressors (Thiopurines or Methotrexate)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Colorectal Cancer, Sleep Quality
Association of Sleep Quality and Mental Status With Early Recurrence and Prognosis of Colorectal Cancer
This is a prospective observational cohort study to explore the effects of sleep quality and mental status on early postoperative recurrence and prognosis in patients with colorectal cancer.
- Conditions
- Colorectal Cancer, Sleep Quality, Mental Status Change
- Trial name
- NCT06443996
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ma Yanlei
Recurrent Prostate Carcinoma, Stage I Prostate Cancer
Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy
This randomized phase II trial studies how well metformin hydrochloride and aspirin work in treating patients with hormone-dependent prostate cancer that has progressed after surgery or radiation therapy.
- Conditions
- Recurrent Prostate Carcinoma, Stage I Prostate Cancer, Stage IIA Prostate Cancer, Stage IIB Prostate Cancer
- Trial name
- PRIMA (NCT02420652)
- Testing
- Aspirin, Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Rutgers, The State University of New Jersey
Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma
An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer
This phase II trial compares the safety and effectiveness of 89Zr-DFO-GmAb positron emission tomography (PET)/computed tomography (CT) compared to contrast-enhanced CT after surgery in detecting clear cell renal cell cancer that…
- Conditions
- Clear Cell Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Stage II Renal Cell Cancer, Stage III Renal Cell Cancer
- Trial name
- NCT06447103
- Testing
- Biospecimen Collection, Bone Scan, Computed Tomography
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Chronic Subdural Hematoma
Postoperative Balloninflation After Evacuation of cSDH
In this prospective, randomized, multicenter trial shall patients with chronic subdural hematoma (cSDH) recruited, who were surgically treated.
- Trial name
- BANISH (NCT04060186)
- Testing
- Balloninflation
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Recurrent Prostate Cancer After Surgery
This Study is Evaluating a New Radiation Treatment Technique for Patients Who Have Had Prostate Cancer, Undergone Surgery for Cancer, and Then Have Evidence That Their Prostate Cancer Has Returned.
There is significant, proven use of radiation for recurrent prostate cancer after surgical resection. This treatment typically is delivered over seven and a half weeks of daily treatments, presenting a burden to patients and the…
- Trial name
- DASBRT-RPC (NCT05946824)
- Testing
- Daily-adaptive Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Angiogenesis, Colon Cancer
Postoperative VEGF and Recurrence After Colon Cancer Surgery
The purpose of this trial is to study the relationship between the angiogenic response to surgical aggression, determined through the serum levels of vascular endothelial growth factor (VEGF) on postoperative day four, and the…
- Conditions
- Angiogenesis, Colon Cancer, Surgery, Recurrence
- Trial name
- NCT04851054
- Testing
- Surgery for colon cancer with intention to cure
- Volunteers
- 280 people
- Sponsor
- Hospital del Mar
Crohn Disease
A Multicentre Study on Rifaximin in Post-operative Endoscopic Crohn's Disease Recurrence Prevention
Crohn's Disease (CD) is a chronic pathology characterized by exacerbations and remissions. Recurrent inflammation can cause bowel strictures, fistulae (often perianal) or abscesses. CD often requires intestinal resection.
- Trial name
- STOP-PER (NCT03537157)
- Testing
- Rifaximin delayed release tablets
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- Alfasigma S.p.A.
Pain, Quality of Life
Robotic Versus Hybrid Assisted Ventral Hernia Repair
Laparoscopic ventral hernia repair (LVHR) may be associated with chronic pain, seroma formation, bulging and failure to restore abdominal wall function.
- Conditions
- Pain, Quality of Life, Recurrence
- Trial name
- ROHYB (NCT05233020)
- Testing
- robotic, hybrid
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Thyroid Cancer Patients, Lymph Node Metastasis
Irreversible Electroporation for Recurrent or Metastatic Cervical Lymph Node Metastases From Thyroid Cancer: A Prospective Multicenter Single-Arm Study
This is a single-arm, open-label, multicenter, exploratory clinical trial designed to systematically evaluate the efficacy, safety, and patient benefit of ultrasound-guided irreversible electroporation (IRE) ablation for…
- Trial name
- IRE-TCLN (NCT07328243)
- Testing
- Irreversible Electroporation (IRE) Ablation
- Where
- 3 sites in China
- Volunteers
- 85 people
- Sponsor
- Tian'an Jiang
Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain
Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors
This phase II trial studies whether low dose dexamethasone works as well as standard dose dexamethasone to reduce brain swelling after brain surgery in patients with primary brain tumors or cancer that has spread from other…
- Conditions
- Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain, Recurrent Malignant Brain Neoplasm
- Trial name
- NCT05139043
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
Colorectal Neoplasms
Clinical Analysis of HIPEC for T4 Colorectal Cancer After Surgery
This multicentric study aims to determine if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to prevent the development of peritoneal carcinomatosis in addition to the standard adjuvant systemic treatment after…
- Trial name
- NCT03221608
- Testing
- Surgery and HIPEC with Lobaplatin, Surgery without HIPEC
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University