Clinical trials: Postoperative Fistula
Pancreatic Cancer
Post-operative Drainage After Pancreaticoduodenectomy
The study compares regular use of surgical drains and no use of surgical drains in patients subjected to pancreaticoduodenectomy with expected low to intermediate risk for post operative pancreatic fistula.
- Trial name
- Drain 1 (NCT05270564)
- Testing
- Drain, No drain
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Linkoeping University
Intraoperative Analgesia, Postoperative Pain
PECS II Versus ICBN Block Plus SCNB for AV Fistula Creation in CRF Patients
Brachial plexus block (BPB) is often utilized for proximal arm arteriovenous access creation. However, the medial upper arm and axilla are often inadequately anesthetized, as the Intercostobrachial nerve (which provides sensory…
- Trial name
- NCT04988776
- Testing
- ultrasUltrasound-guided Intercostobrachial nerve block supplemental to supraclavicular block with 30 ml 0.25% bupivacaine (15 ml 0.5% bupivacaine will be added to 15 m, ultrasound-guided pectoral nerves block type II supplemental to supraclavicular block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Postoperative Acute Pancreatitis, Pancreaticoduodenectomy
Clinical and Economic Validation of the ISGPS Definition of PPAP
This prospective validation study aims to investigate the incidence of PPAP after pancreaticoduodenectomy (PD) by applying the ISGPS definition and grading system, to demonstrate its clinical impact by examining associated…
- Conditions
- Postoperative Acute Pancreatitis, Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Postoperative Complications
- Trial name
- ISGPS-PPAP (NCT05680623)
- Testing
- PPAP diagnosis
- Where
- Italy
- Volunteers
- 2,900 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor
Pancreatic Fistula After Minimally Invasive Enucleation
Patients suffering from postoperative pancreatic fistula (POPF) after minimally invasive enucleation (MIEN) show a characteristic pattern of longer duration and milder symptoms, which is different from pancreatic fistula after…
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor, Solid Pseudopapillary Tumor of the Pancreas
- Trial name
- NCT06557408
- Where
- China
- Volunteers
- 173 people
- Sponsor
- Fudan University
Pancreas; Fistula, Pancreas Cancer
Assessing Pancreatic Fistula Rates After Distal Pancreatectomy Using AEON Endostapler
This prospective, observational study evaluates the rate of postoperative pancreatic fistula (POPF) following distal pancreatectomy (DP) using the AEON™ Endostapler.
- Conditions
- Pancreas; Fistula, Pancreas Cancer, Pancreatic Disease, Surgery-Complications
- Trial name
- AEON-DP (NCT06764134)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Larynx Cancer, Pharynx Cancer
Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy
This trial aims to determine if intra-operative use of human dehydrated amnion chorion allograft improves post-operative patient healing outcomes.
- Conditions
- Larynx Cancer, Pharynx Cancer, Pharyngocutaneous Fistula
- Trial name
- NCT03479463
- Testing
- Dehydrated human amnion/chorion membrane
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- MiMedx Group, Inc.
Postoperative Fistula
Teduglutide for Enterocutaneous Fistula (ECF)
The purpose of this study is to determine whether Teduglutide is safe and feasible to be given for the treatment of enterocutaneous fistula (ECF).
- Trial name
- NCT02889393
- Testing
- Teduglutide, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Daniel Dante Yeh
Pancreatic Fistula
Ultrasound Elastography for Prediction of Postoperative Pancreatic Fistula
The purpose of this study is to assess the value of preoperative objective modalities such as endoscopic ultrasound elastography and magnet resonance imaging in predicting development of postoperative pancreatic fistula in…
- Trial name
- PMPPOPF (NCT02589379)
- Testing
- Pancreatic Resection
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- University of Zurich
Distal Pancreatectomy, Postoperative Pancreatic Fistula
Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula
Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers.
- Trial name
- PREPARE (NCT04220931)
- Testing
- botulinum toxin injection
- Where
- France
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gastrointestinal Fistula, Enteral Nutritional Support
Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery
The incidence of clinically significant anastomotic leaks (AL) after upper gastrointestinal (GI) surgery is approximately 4 % - 20 %, and the associated mortality can be as high as 80 % .
- Trial name
- NUTRILEAK (NCT03742752)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein
Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein, Albumin
- Trial name
- popf (NCT06300801)
- Testing
- Is the preoperative c-reactive protein/albumin ratio successful in predicting postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy?
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Periampullary Cancer, Postoperative Pancreatic Fistula
Pancreatic Head Resection or Total Pancreatectomy With Islet Autotransplantation in Patients With Periampullary Cancer and High Risk Profile for the Development of Postoperative Pancreatic Fistula
The primary objective of this clinical trial is to evaluate whether primary total pancreatectomy with simultaneous islet autotransplantation compared with pancreatic head resection (alone) can reduce perioperative morbidity and…
- Trial name
- XandTX (NCT05843877)
- Testing
- Intraportal transplantation of isolated autologous pancreatic islets after total pancreatectomy, Pancreaticoduodenectomy (classic Whipple or pylorus-preserving)
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Technische Universität Dresden
Pancreatic Cancer, Adult, Margin, Tumor-Free
Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.
- Conditions
- Pancreatic Cancer, Adult, Margin, Tumor-Free, Surgery Site Fistula, Recurrence Tumor
- Trial name
- NCT04136522
- Testing
- conventional pancreaticoduodenectomy, total mesopancreas excision including superior mesenteric artery first approach
- Where
- South Korea
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Pancreatic Fistula
One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
The aim of this study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "One-layer duct-to-mucosa pancreaticojejunostomy" in pancreatoduodenectomy, which could provide a feasible option to pancreatic…
- Trial name
- NCT02511951
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 114 people
- Sponsor
- The Second Hospital of Anhui Medical University
Pancreatic Fistula
Prophylactic Pancreatic Stent for the Prevention of Post Operative Pancreatic Fistula
Postoperative pancreatic fistula (POPF) remains one of the most harmful complications after pancreatic resection. Some studies have indicated that endoscopic pancreatic stenting was effective in the treatment of POPF.
- Trial name
- NCT03822676
- Testing
- Prophylactic pancreatic stent
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Peking Union Medical College Hospital
Anal Fistula Surgery, Anal Fistula
The Use of Electronic Bidets Compared to Water Rinsing After Surgery for Anal Fistula or Haemorrhoidal Disease: a Pilot Study
There is still much to discover in the field of proctological postoperative care. There has already been some, albeit very little, research about its use post-haemorrhoidectomy as well as its possible effect on anal fissures, but…
- Conditions
- Anal Fistula Surgery, Anal Fistula, Hemorrhoidal Disease, Hemorrhoid Surgery
- Trial name
- bidet (NCT07874711)
- Testing
- Electronic bidet, standard water rinsing
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Pancreatoduodenectomy
Neck Division Level and Postoperative Pancreatic Fistula After Pancreaticoduodenectomy
Brief Summary:* Aim of the study : To evaluate if the neck division level significantly influences the postoperative pancreatic fistula rate of pancreatico-jejunal anastomosis after pancreatoduodenectomy.
- Trial name
- PaNECK (NCT03850236)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Surgery
Prevention of Postoperative Pancreatic Fistula by Somatostatin
The purpose of this study is to determine whether somatostatin is more effective that octreotide in the prevention of post-pancreatectomy pancreatic fistula
- Trial name
- PREFIPS (NCT03000946)
- Testing
- Somatostatin, Octreotide
- Where
- 2 sites in France
- Volunteers
- 655 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Pancreatitis, Pancreatic Fluid Collection
Management and Outcomes of Local Complications of Acute Pancreatitis and Postoperative Pancreatic Fistula
This multicenter prospective observational registry will evaluate the clinical characteristics and treatment outcomes of adults with local complications of acute pancreatitis or postoperative pancreatic fistula.
- Conditions
- Acute Pancreatitis, Pancreatic Fluid Collection, Postoperative Pancreatic Fistula
- Trial name
- WONDERFUL (NCT07862088)
- Testing
- Routine Clinical Management of Local Complications
- Where
- 12 sites in Japan
- Volunteers
- 5,000 people
- Sponsor
- Tokyo University
Pancreaticoduodenectomy
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the standard treatment for tumors of the pancreatic head, distal bile duct, duodenum, and ampulla of Vater.
- Trial name
- NCT06322680
- Testing
- Main pancreatic duct and biliary duct external drainage, Main pancreatic duct and biliary duct internal drainage
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Zhongshan Hospital