Clinical trials: Postoperative Infection of Incision
Surgical Site Infection, Sternal Infection
D-PLEX 302: Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery
Prospective, Multinational, Multicenter, Randomized, Parallel Controlled, Two arms, Single Blind, Study to Assess the Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SOC) IV Prophylactic…
- Conditions
- Surgical Site Infection, Sternal Infection, Cardiac Surgery
- Trial name
- NCT03558984
- Testing
- D-PLEX, Standard of Care
- Where
- 3 sites in United States, Israel
- Volunteers
- 2 people
- Sponsor
- PolyPid Ltd.
Surgical Site Infection
Protocol Effect of Negative Pressure Drain to Reducing Surgical Site Infection in Surgical Wound of Abdominal Surgery
Surgical site infection (SSI) is one of main complication in surgery. It usually occurs within 30 days post operation. The superficial SSI is an infection of skin and subcutaneous layer, clinically presented by pus oozing.
- Trial name
- NCT05865821
- Testing
- Negative pressure drainage, No pressure drain
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Hydrocephalus, Ventriculoperitoneal Shunt Infection
Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies
Objectives Primary: To measure the reduction in VP shunt infection rates using topical vancomycin powder. Secondary: To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory).
- Conditions
- Hydrocephalus, Ventriculoperitoneal Shunt Infection, Surgical Site Infection (SSI), Cerebrospinal Fluid Shunt Infection
- Trial name
- NCT07547826
- Testing
- Topical Vancomycin Powder, Standard Perioperative Care
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Assiut University
Post-operative Infections
Reduction in IV Associated Contamination
The purpose of this study is to investigate whether implementing a novel syringe and IV stopcock cap system impregnated with alcohol will reduce IV catheter bacterial contamination and infections in patients.
- Trial name
- NCT01426217
- Testing
- Passive Bundle PSI (Problem Solving Innovations) Medical HubScrub, PSI Medical DocIt
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Neurosurgery
Surgical and Non-surgical Infections of Neurosurgical Patient: Before-after Cohort Study
Continuous surveillance in 2003-2017 allowed to detect HAIs in patients staying in a 42-bed neurosurgery unit with 6 intensive neurosurgical supervision beds. 10,332 surgical patients were qualified for the study.
- Trial name
- NCT03759652
- Testing
- before-after study
- Where
- Poland
- Volunteers
- 10,332 people
- Sponsor
- Polskie Towarzystwo Zakażeń Szpitalnych
Surgery, Surgical Site Infection
Intraoperative Hygiene Measures and Surgical Site Infections
Surgical site infections are associated with high morbidity and cost Hypothesis: Extended intraoperative hygiene measures decrease surgical site infections in general surgery compared to standard hygiene measures.
- Conditions
- Surgery, Surgical Site Infection, Hygiene, Discipline
- Trial name
- NCT00555815
- Where
- Switzerland
- Volunteers
- 1,032 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Perianal Abscess, Perianal Infections
Packing of Perianal Abscess Cavities
The aim of this trial is to compare internal wound packing to no packing in postoperative management following incision and drainage of perianal abscess.
- Conditions
- Perianal Abscess, Perianal Infections, Peri Rectal Abscess, Abscess; Anus
- Trial name
- PPAC2 (NCT03315169)
- Testing
- External dressing, Packing of perianal abscess cavity
- Where
- 50 sites in United Kingdom
- Volunteers
- 433 people
- Sponsor
- Manchester University NHS Foundation Trust
Craniotomy Surgery, Preventive Health Care
The Effect of Bundle Application on Surgical Site Infection
Surgical site infections (SSI) are the most common complications after surgical operations and are in the top three in Healthcare Associated Infections (HIE).
- Trial name
- NCT06724354
- Testing
- The Surgical Site Infections Precaution Package Form includes the parameters that should be applied to patients before, during and after surgery.
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Surgical Site Infection
Novosyn® CHD vs Polyglactin 910 Suture to Close Wounds After Emergency or Elective Laparotomy or Laparoscopic Surgery
The aim of the study is to elucidate, if the colonization of bacteria is lower on the Novosyn® CHD suture compared to uncoated Polyglactin 910 suture, which will be assessed by the incidence of surgical site infections (SSI: A1…
- Trial name
- POLYNOVO-CHD (NCT05966961)
- Testing
- Novosyn® in emergency or elective laparotomy or laparoscopic surgery, Polyglactin 910 in emergency or elective laparotomy or laparoscopic surgery
- Where
- 4 sites in Italy, Spain
- Volunteers
- 2,998 people
- Sponsor
- Aesculap AG
Staphylococcus Aureus Colonization, Surgical Site Infections
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment…
- Conditions
- Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
- Trial name
- NCT06378359
- Testing
- Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Infection, Spinal Injuries
The Value of Home Chlorhexidine Pre-Surgical Wash Before Spine Surgery
The study team hypothesizes that at-home cleansing of the surgical site with chlorhexidine wipes provide no added benefit to decreasing microbial activity or preventing surgical site infections.
- Trial name
- NCT02767427
- Testing
- Chlorhexidine Wipes, No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Surgical Site Infection
The Use of Diluted Povidone Iodine Irrigation in Spine Surgery
The purpose of the study is to determine whether diluted Povidone Iodine solution used to irrigate surgical wounds during spine surgery decreases the incidence of surgical site infections.
- Trial name
- NCT01577524
- Testing
- Povidone-Iodine, Saline
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- Attabib, Najmedden, M.D.
Incidence of Surgical Site Infection, Morality
Changing the Surgical Team for Wound Closure and Surgical Site Infection
Surgical site infection is a frequent complication after abdominal surgery. The wound closure is done at the end of the procedure when the attention of the entire team may be affected because of tiredness and reduced attention of…
- Conditions
- Incidence of Surgical Site Infection, Morality, Fascial Hernia
- Trial name
- NCT04503642
- Testing
- Changing the surgical team for wound closure
- Where
- Switzerland
- Volunteers
- 1,160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Surgical Site Infection
Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients
Intervention: This study will involve three different study arms with different interventions prior to surgery: (1) shower only, (2) shower plus Theraworx wipes, (3) shower plus chlorhexidine wipes Study Design: Single center RCT…
- Trial name
- NCT03401749
- Testing
- Chlorhexidine Gluconate 2% Wipe, Theraworx Bath Wipes
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- University of Alabama at Birmingham
Surgical Site Infection
Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion
Surgical site infections (SSI) after spine surgery may occur in up to 12% of cases and can lead to increased morbidity, and healthcare costs In this randomized controlled trial the investigators aim to prospectively investigate…
- Trial name
- VANCO (NCT04017468)
- Testing
- Vancomycin
- Where
- 7 sites in Switzerland
- Volunteers
- 450 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Wound Infection Rate After Surgery, Impact of Wound Infection on Pain and Wound Healing
Impact of Preoperative Local Water-Filtered Infrared-A (wIRA) Irradiation on Postoperative Wound Healing
The purpose of this study is to dermine whether local-water filtered infrared-A (wIRA) irradiation can reduce postoperative wound infection.
- Trial name
- Hydrosun (NCT01654679)
- Testing
- wIRA irradiation, visible light only
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Research Foundation
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Surgical Site Infections
PHMB-based Antiseptic Use in Full-thickness Surgical Wounds
To study the effect of applying a PHMB-based antiseptic solution to tie-over dressings in full-thickness surgical wounds in dermatologic surgery in order to minimise the development of surgical site infections.
- Trial name
- NCT02253069
- Testing
- Applying Prontosan antiseptic solution to tie-over dressings
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Surgical Site Infections
Examination of the Effect of Skin Antisepsis With Pre-heated Povidone Iodine on Surgical Site Infections: A Quasi-Experimental Study
Surgical Site Infections (SSI) develop as a complication of surgical care 30-90 days after surgery without implants and within 1 year after implanted operations.
- Trial name
- NCT04969302
- Testing
- Follow-up
- Where
- Cyprus
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Urethral Stricture
A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture
Male urethral stricture is one of the common diseases in urology, with risk factors including a history of hypospadias surgery, indwelling urinary catheterization or instrumental manipulation, trauma, transurethral surgery, and…
- Trial name
- NCT07508566
- Testing
- Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine