Clinical trials: Postoperative Inflammation, open to volunteers
Head and Neck Cancers
Impact of HMB Supplementation on Inflammation and Outcomes in Head and Neck Cancer
Cancer patients undergoing surgery are at high risk of malnutrition due to the effects of the tumor and surgical stress, which can lead to worse clinical outcomes.
- Trial name
- NCT07675421
- Testing
- HMB, hydroxymethylbutyrate
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Federal University of Minas Gerais
Postoperative Pain Management, Laparoscopic Hysterectomy
Intrathecal Morphine Versus Trocar-Site and Intraperitoneal Bupivacaine for Quality of Recovery After Laparoscopic Hysterectomy
This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing…
- Conditions
- Postoperative Pain Management, Laparoscopic Hysterectomy, Postoperative Recovery
- Trial name
- ITM-LH-QoR (NCT07232108)
- Testing
- Intrathecal Morphine, Trocar-Site Bupivacaine Infiltration, Intraperitoneal Bupivacaine spray
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ataturk University
Inflammation, Osteoarthritis
Photobiomodulation Therapy in Patients Receiving Total Knee Arthroplasty
Photobiomdoulation is the use of near-infrared light to relieve pain, stimulate healing and reduce inflammation. Swelling and inflammation is a common condition after orthopedics surgeries over extremity and spine.
- Conditions
- Inflammation, Osteoarthritis, Post Operative Pain
- Trial name
- NCT06426251
- Testing
- Photobiomodulation
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Postoperative Complications, Critical Illness
IL-6 and Hemogram-Derived Inflammatory Indices for Mortality Prediction in Postoperative ICU Patients
This prospective observational cohort study aims to evaluate the predictive value of interleukin-6 (IL-6) levels and hemogram-derived inflammatory scores for morbidity and in-hospital mortality in postoperative patients admitted…
- Conditions
- Postoperative Complications, Critical Illness, Inflammation, Intensive Care Unit Admission
- Trial name
- NCT07460141
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ezgi Günaydın
Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection
Arterial Stiffness During Negative Pressure Wound Therapy for Abdominal Wall Wounds
WALLAS is a small observational study of 30 adults with complex wounds in the abdominal wall after surgery. All participants will receive negative pressure wound therapy (NPWT) because their treating team considers it…
- Conditions
- Postoperative Abdominal Wall Wound Complications, Surgical Wound Infection, Surgical Wound Dehiscence, Mesh-Associated Wound Complications
- Trial name
- WALLAS (NCT07907705)
- Testing
- Negative Pressure Wound Therapy (NPWT)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Dávid Ágoston Kovács
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Surgical Site Infection (SSI), Wound Healing Complication
Prophylactic Use of ciNPWT in Gynecologic Laparotomy
This is a prospective, open-label, non-randomized interventional feasibility study with a nested qualitative analysis. The study exploratively verifies the feasibility of targeted prophylactic closed incision negative pressure…
- Conditions
- Surgical Site Infection (SSI), Wound Healing Complication, Seroma, Hematoma
- Trial name
- NCT07645547
- Testing
- closed incision negative pressure wound therapy (ciNPWT)
- Volunteers
- 30 people
- Sponsor
- University Hospital Hradec Kralove
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Rhinoplasty, Edema
Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre
This single-centre, randomized, double-blind, sham-controlled clinical trial evaluates whether preoperative photobiomodulation (PBM) with red and infrared light can reduce early postoperative periorbital edema in patients…
- Trial name
- NCT07033039
- Testing
- Photobiomodulation, Simulation of Photobiomodulation, Standard treatment protocol
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Organ Dysfunction, Inflammation in Cardiac Surgery
Epigenetic Susceptibility to Inflammatory Complications After Cardiac Surgery
This study aims to better understand 3 crucial questions: 1. Why do some patients experience more severe complications after heart surgery than others? 2.
- Conditions
- Organ Dysfunction, Inflammation in Cardiac Surgery, Epigenetic, Coronary Artery Bypass Graft
- Trial name
- Epi-SICCS (NCT07865026)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Glasgow
Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG)
Colchicine for the Prevention of Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Single-Center, Strategy-Stratified, Randomized, Double-Blind, Placebo-Controlled Trial
Post-operative atrial fibrillation after coronary artery bypass grafting (CABG)
- Trial name
- NCT07611019
- Testing
- Colchicine 0.5 MG oral tablet twice daily
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Breast Neoplasms, Ischemia-Reperfusion Injury
DIEP Flap Breast Reconstruction: Perioperative Biomarkers and Outcomes
Brief Summary This observational study will follow patients who undergo DIEP flap breast reconstruction to better understand a common surgical challenge called ischemia-reperfusion (I/R) injury.
- Conditions
- Breast Neoplasms, Ischemia-Reperfusion Injury, Postoperative Complications, Wound Healing
- Trial name
- NCT07263347
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hubei Cancer Hospital
Obesity, Bariatric Surgery Candidate
Modulation of the Inflammatory Response in Bariatric Surgery
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with…
- Conditions
- Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain
- Trial name
- MRICBx3 (NCT06915558)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital HM Nou Delfos
Umbilical Hernia Repair
Topical Tranexamic Acid Spray Versus No Spray on Postoperative Outcomes Following Mesh Repair of Umbilical Hernia
Umbilical hernia is a type of ventral hernia that occurs commonly in adulthood, and mesh reinforcement is well established since there is a reduced recurrence rate when compared to suture repair.
- Trial name
- NCT07845370
- Testing
- Topical Tranexamic Acid Spray, No Topical Tranexamic acid
- Where
- Pakistan
- Volunteers
- 252 people
- Sponsor
- Dr Mudassar Saeed Pansota
Surgical Site Infection, Surgical Wound
Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies
The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients…
- Conditions
- Surgical Site Infection, Surgical Wound, Surgical Incision, Emergency Laparotomies
- Trial name
- NCT05989386
- Testing
- 0.9% saline solution, Povidone-iodine Swab
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Total Knee Replacement, Knee Osteoarthritis
Circulatory Exercise After Total Knee Replacement
Total knee replacement is commonly associated with early postoperative inflammation, edema, pain, and reduced mobility. This randomized controlled trial will evaluate whether adding a simple circulatory exercise program to…
- Conditions
- Total Knee Replacement, Knee Osteoarthritis, Postoperative Edema, Postoperative Inflammation
- Trial name
- NCT07688642
- Testing
- standard postoperative TKR rehabilitation, Standard Rehabilitation Plus Circulatory Exercise
- Volunteers
- 68 people
- Sponsor
- Assiut University
Postoperative Cognitive Dysfunction
Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery
Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life.
- Trial name
- NCT07681063
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Cardiac Surgery, Cardiopulmonary Bypass
Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.
The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Platelet Activation
- Trial name
- PLACARD (NCT07630987)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Locally Advanced Breast Cancer (LABC), Postoperative Inflammation
Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy
This study evaluates whether preoperative shoulder range-of-motion exercises influence postoperative inflammatory response, pain, shoulder function, and quality of life in patients with locally advanced breast cancer undergoing…
- Conditions
- Locally Advanced Breast Cancer (LABC), Postoperative Inflammation, Prehabilitation
- Trial name
- NCT07420335
- Testing
- Preoperative shoulder exercise, Standard preoperative care
- Where
- Indonesia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia