Clinical trials: Postoperative Inflammatory Response, active
Lumbar Discectomy
Effects of an Anti-Inflammatory Diet on Inflammatory and Neuroendocrine Responses After Lumbar Discectomy
This study was aimed to investigate the effects of pre-operative nutritional status and post-operative dietary interventions on inflammation, pain, and recovery in adults undergoing lumbar disc surgery.
- Trial name
- NCT07918729
- Testing
- Anti-inflammatory Dietary Intervention, Standart Dietary Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hacettepe University
Quality of Recovery After Mastectomy, Serratus Anterior Plane Block
Timing of Serratus Anterior Plane Block in Mastectomy Surgery
Postoperative pain following mastectomy may adversely affect early mobilization, patient comfort, and overall quality of recovery.
- Conditions
- Quality of Recovery After Mastectomy, Serratus Anterior Plane Block, Postoperative Pain, Mastectomy
- Trial name
- NCT07661212
- Testing
- Ultrasound-Guided Serratus Anterior Plane Block, Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS)
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
- Trial name
- VISION-2 (NCT07300579)
- Testing
- Continuous vital signs measurement device
- Where
- 3 sites in Canada
- Volunteers
- 20,000 people
- Sponsor
- Hamilton Health Sciences Corporation
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Enhanced Recovery After Anesthesia
Intraoperative Lidocaine Infusion
This study aims to evaluate the analgesic and anti-inflammatory effect of perioperative intravenous lidocaine infusion and in turn the return of gastric motility in patients undergoing elective laparoscopic cholecystectomy.
- Trial name
- IV (NCT07150481)
- Testing
- IV Lidocaine infusion, IV normal saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Craniotomy Surgery
Effects of Ultrasound-Guided Scalp Block on Opioid Use, Hemodynamics, and Postoperative Inflammation in Craniotomy
This study shows that in craniotomy patients using a skull pin head holder, an ultrasound-guided scalp block reduces perioperative opioid consumption, improves hemodynamic stability, and decreases the inflammatory response.
- Trial name
- NCT07545655
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures
Electroacupuncture at ST36 for Reducing Postoperative Inflammation After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery using cardiopulmonary bypass can trigger a marked systemic inflammatory response and may contribute to postoperative organ dysfunction and delayed recovery.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Cardiac Surgical Procedures, Postoperative Complications (Cardiopulmonary)
- Trial name
- EAST36-CPB (NCT07795112)
- Testing
- Electroacupuncture at Bilateral ST36, Acupuncture Without Electrical Stimulation at Bilateral ST36
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sir Run Run Shaw Hospital
Sepsis, Osteoporotic Hip Fracture
Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)
Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death.
- Conditions
- Sepsis, Osteoporotic Hip Fracture, Hip Fracture
- Trial name
- MDW (NCT07350785)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Cardiac Surgery, Cardiopulmonary Bypass
Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.
The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Platelet Activation
- Trial name
- PLACARD (NCT07630987)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Sepsis, Lung Injury
Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery
This randomized controlled trial will compare the effects of intraoperative inhalational anesthesia versus intravenous anesthesia on postoperative lung injury in septic patients undergoing surgery.
- Trial name
- NCT07601256
- Testing
- Inhalation Anesthesia, intravenous anesthesia
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Arrhythmia, Acute Kidney Injuries
This is an Observational Study That Aims to Demonstrate Postoperative Risk Factors in Pediatric Cardiac Surgery
This retrospective observational study aims to identify risk factors for postoperative complications in children undergoing cardiac surgery at a tertiary hospital in Brazil.
- Conditions
- Arrhythmia, Acute Kidney Injuries, Sepsis, Pneumopathy
- Trial name
- PEDS-CARE (NCT06985082)
- Testing
- THERE IS NOT A INTERVENTION
- Volunteers
- 310 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Cardiac Arrest (CA), Post Cardiac Arrest Syndrome
TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.
The investigators assessed the effect of TNF-α antagonism within 6 hours of return of spontaneous circulation on 30-day mortality in patients who remained comatose after cardiopulmonary resuscitation (CPR) following cardiac…
- Trial name
- NCT07176754
- Testing
- Infliximab
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Peking University Third Hospital
Nephrolithiasis, Urosepsis
Serum Endotoxin Assay to Predict the Development of Postoperative Infectious Complications and Systemic Inflammatory Response Following Percutaneous Nephrolithotomy.
The aim of the study is to establish an infectious risk stratification system based on pre-and post-operative blood endotoxin profile.
- Trial name
- NCT04669886
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Septic Shock, Vasopressor Resistance
Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic Shock
Septic shock is one of the most frequent reasons for admission to intensive care units and remains associated with a high mortality rate of approximatively 40% at 28 days.
- Trial name
- ADRESS (NCT07569536)
- Testing
- Dexmedetomidine 100 µg/mL, intravenous solution, Stardard care
- Where
- 18 sites in France
- Volunteers
- 360 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Bariatric Surgery Candidate
Modulation of the Inflammatory Response in Bariatric Surgery
This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with…
- Conditions
- Obesity, Bariatric Surgery Candidate, Inflammation, Postoperative Pain
- Trial name
- MRICBx3 (NCT06915558)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Intravenous Anesthesia (OBA-IV), Opioid-Based Inhalational Anesthesia (OBA-Inh)
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital HM Nou Delfos
Postoperative Pain
Effect of Genetic Polymorphisms on Response to Preoperative NSAIDs in Endodontic Postoperative Pain Management
This study aims to evaluate the influence of genetic polymorphisms on the effectiveness of preoperative non-steroidal anti-inflammatory drugs (NSAIDs) in managing postoperative pain following endodontic treatment.
- Trial name
- NCT06937853
- Testing
- Ibuprofen 600 mg, diclofenac sodium
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer
Effects of SPSIP Block on Perioperative Inflammation and TLR4 in Breast Cancer Surgery
This study will investigate whether the serratus posterior superior intercostal plane (SPSIP) block improves postoperative recovery after breast cancer surgery. Participants will be randomly assigned to one of two groups.
- Conditions
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer, Toll-Like Receptors
- Trial name
- SPSIP-TLR4 (NCT07843212)
- Testing
- Serratus posterior superior intercostal plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mucahide Emine Fidancı Kuas
Urolithiasis
Risk Factors for Postoperative Fever and Sepsis Following Retrograde Intrarenal Surgery
This prospective clinical study aims to evaluate preoperative, intraoperative, and postoperative characteristics of patients undergoing retrograde intrarenal surgery (RIRS) for urinary stone disease.
- Trial name
- SARIS (NCT07295925)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- TC Erciyes University
Pancreatectomy, Pancreatic Surgery
PAN-ICIS Study: ICIS for Early Detection of Infectious Complications in Pancreatic Surgery
This study examines a new blood test called ICIS, which may help detect infections earlier after pancreatic surgery. Patients will have routine blood samples taken during their hospital stay, with no extra procedures required.
- Conditions
- Pancreatectomy, Pancreatic Surgery, Intensive Care (ICU), Inflamatory Markers
- Trial name
- PAN-ICIS (NCT07248527)
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Charles University, Czech Republic